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    A STANDARD OF CARE PROTOCOL FOR REDUCING LONG AND SHORT-TERM ADVERSE EFFECTS CAUSED BY RADIOTHERAPY OR RADIOSURGERY TREATMENT
    1.
    发明申请
    A STANDARD OF CARE PROTOCOL FOR REDUCING LONG AND SHORT-TERM ADVERSE EFFECTS CAUSED BY RADIOTHERAPY OR RADIOSURGERY TREATMENT 审中-公开
    “放射治疗”或“放射治疗”治疗导致长期和短期不良反应的护理标准

    公开(公告)号：WO2015087319A1

    公开(公告)日：2015-06-18

    申请号：PCT/IL2014/051065

    申请日：2014-12-07

    Applicant: CONVERGENT R.N.R LTD

    Inventor： BAR-DAVID, Aharon ,  MARKOVICH, Miri ,  BURSHTEIN, Zeev ,  HAREL, Zeev

    IPC: A61N5/10

    CPC classification number: A61N5/1077 ,  A61N5/1031 ,  A61N5/1048 ,  A61N5/1084

    Abstract: A standard of care protocol for increasing efficiency of a radiotherapy or radiosurgery treatment and reducing the treatment's side effects by radiating with a converging x-ray beam source emitting a converging x-ray beam (102) towards at least one volume of treatment (VOT) (103) within a patient's body; the beam is passing through at least one organ preceding said VOT (PO) (105) and at least one organ distal to said VOT (DO) (106); the VOT is receiving, on average, at least 80% of maximum dose whilst thr PO and DO are receiving, on average, no more than 40% of the maximum dose.

    Abstract translation: 一种用于提高放射治疗或放射外科治疗效率的护理方案的标准，并且通过用朝向至少一个治疗体积（VOT）发射会聚的X射线束（102））的会聚x射线束源辐射来减少治疗的副作用， （103）在患者体内; 光束穿过所述VOT（PO）（105）之前的至少一个器官和远离所述VOT（DO）（106）的至少一个器官; VOT平均接受最大剂量的至少80％，而PO和DO接受平均不超过最大剂量的40％。

    MEANS AND METHODS FOR TARGETED X-RAY THERAPY
    2.
    发明申请
    MEANS AND METHODS FOR TARGETED X-RAY THERAPY 审中-公开
    用于靶向X射线治疗的方法和方法

    公开(公告)号：WO2016024279A1

    公开(公告)日：2016-02-18

    申请号：PCT/IL2015/050824

    申请日：2015-08-12

    Applicant: CONVERGENT R.N.R LTD

    Inventor： HAREL, Zeev ,  BURSHTEIN ZEEV, Zeev ,  BAR-DAVID, Aharon ,  MARKOVICH, Miri

    IPC: A61N5/10 ,  A61K41/00

    CPC classification number: A61M37/00 ,  A61K9/0009 ,  A61K41/00 ,  A61K41/0052 ,  A61M2037/0007 ,  A61N5/10 ,  A61N2005/1091 ,  A61N2005/1098

    Abstract: The present invention provides a method for activating a pro-drug in vivo comprising the steps of: (a) administering a pro-drag to a subject; (b) locating a target site which has been at least partially dosed with the pro-drug at a predetermined concentration; and (d) exposing the target site to X-ray radiation. The step of exposing the target site to X-ray radiation is characterized by providing a converging X-ray of a controllable waist, substantially uniform at the target site, sufficient to convert the pro-drug to an active drug, whilst the X-ray photon dosage at the target site is higher than the X-ray photon dosage at an adjacent non target site.

    Abstract translation: 本发明提供了一种在体内活化前药的方法，包括以下步骤：（a）向受试者施用阻遏物; （b）将至少部分给予前药的目标部位定位在预定浓度下; 和（d）将目标部位暴露于X射线辐射。 将目标部位暴露于X射线辐射的步骤的特征在于提供可控腰部的会聚X射线，其在目标部位基本均匀，足以将前药转化为活性药物，同时X射线 目标位点的光子剂量高于相邻非靶位点处的X射线光子剂量。

    NEW CONSTRUCTIONS OF X-RAY LENSES FOR CONVERGING X-RAYS
    4.
    发明申请
    NEW CONSTRUCTIONS OF X-RAY LENSES FOR CONVERGING X-RAYS 审中-公开
    用于融合X射线的X射线透镜的新构造

    公开(公告)号：WO2016108235A1

    公开(公告)日：2016-07-07

    申请号：PCT/IL2015/051265

    申请日：2015-12-29

    Applicant: CONVERGENT R.N.R LTD

    Inventor： BAR-DAVID, Aharon ,  MARKOVICH, Miri ,  KELLER, Avigail ,  BURSHTEIN, Zeev ,  HAREL, Zeev

    IPC: G21K1/06

    CPC classification number: G21K1/067 ,  G21K1/06 ,  G21K2201/062

    Abstract: New techniques for converging X-rays are described. These techniques can be used for the design of an X-ray lens for the converging of X-rays into a focal point or a focal volume using a point source or an extended source. The aim of this design is to add important new features over those of the previous suggested patented device. The additional features are to provide control of the size and shape of the focal volume, the beam shape, uniformity and quality, and ease of manufacturing.

    Abstract translation: 描述了用于会聚X射线的新技术。 这些技术可用于设计用于使用点源或扩展源将X射线会聚到焦点或焦点体积的X射线透镜。 这种设计的目的是增加与以前提出的专利设备相比的重要新功能。 附加的特征是提供焦距体积的大小和形状的控制，光束形状，均匀性和质量以及易于制造。

    MEANS AND METHODS FOR TARGETED X-RAY THERAPY
    5.
    发明公开
    MEANS AND METHODS FOR TARGETED X-RAY THERAPY 审中-公开
    用于靶向X射线治疗的手段和方法

    公开(公告)号：EP3180085A1

    公开(公告)日：2017-06-21

    申请号：EP15832565.4

    申请日：2015-08-12

    Applicant: Convergent R.N.R Ltd

    Inventor： HAREL, Zeev ,  BURSHTEIN ZEEV, Zeev ,  BAR-DAVID, Aharon ,  MARKOVICH, Miri

    IPC: A61N5/10 ,  A61K41/00

    CPC classification number: A61M37/00 ,  A61K9/0009 ,  A61K41/00 ,  A61K41/0052 ,  A61M2037/0007 ,  A61N5/10 ,  A61N2005/1091 ,  A61N2005/1098

    Abstract: The present invention provides a method for activating a pro-drug in vivo comprising the steps of: (a) administering a pro-drag to a subject; (b) locating a target site which has been at least partially dosed with the pro-drug at a predetermined concentration; and (d) exposing the target site to X-ray radiation. The step of exposing the target site to X-ray radiation is characterized by providing a converging X-ray of a controllable waist, substantially uniform at the target site, sufficient to convert the pro-drug to an active drug, while the X-ray photon dosage at the target site is higher than the X-ray photon dosage at an adjacent non target site.

    Abstract translation: 本发明提供了一种活体内激活前体药物的方法，其包括以下步骤：（a）将前体药物施用于受试者; （b）将已经至少部分用前药给药的靶位点定位在预定浓度; 和（d）将目标部位暴露于X射线辐射。 使目标部位暴露于X射线辐射的步骤的特征在于提供可控腰部的会聚X射线，其在目标部位基本均匀，足以将前药转化为活性药物，而X射线 目标部位的光子剂量高于相邻非目标部位的X射线光子剂量。

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