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公开(公告)号：WO2022061186A1
公开(公告)日：2022-03-24
申请号：PCT/US2021/050991
申请日：2021-09-17
Applicant: CYTOVERIS INC.
Inventor： FOURNIER, David , PANDEY, Rishikesh
Abstract: A method and system for analyzing a tissue sample is provided. The method includes: a) sequentially interrogating a tissue sample with excitation lights, wherein at least one of the excitation lights is configured to produce autofluorescence emissions from one or more biomolecules of interest, and diffuse reflectance signals from the tissue sample; b) using a photodetector to detect the autofluorescence emissions and/or the diffuse reflectance signals from the tissue sample, and to produce photodetector signals representative of the detected said autofluorescence emissions and/or the detected said diffuse reflectance signals; c) filtering the light emitted or reflected from the tissue sample; d) processing the photodetector signals for each sequential application of excitation light, including producing an image representative of the photodetector signals produced by each sequential application of excitation light; and e) analyzing the tissue sample using each image to identify the presence of diseased tissue within the tissue sample.
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2.发明申请
公开(公告)号：WO2023278673A1
公开(公告)日：2023-01-05
申请号：PCT/US2022/035686
申请日：2022-06-30
Applicant: CYTOVERIS INC.
Inventor： FOURNIER, David , KERSEY, Alan
IPC: G02B21/00 , G02B21/16 , G02B21/08 , G02B21/06 , G02B21/361
Abstract: A system and method for imaging a tissue sample is provided. The system includes a dome, at least one excitation light source, and at least one light detector. The dome is configured to surround at least a portion of a tissue sample. The dome has interior surfaces that define a dome interior cavity. The excitation light source is configured to produce light at one or more wavelengths. The excitation light source is in photometric communication with the dome. The dome interior surfaces are configured to reflect the light at the one or more predetermined wavelengths. The dome is configured to cause the light at the one or more predetermined wavelengths to be incident to the exposed surface of the tissue sample in a substantially uniform manner. The light detector is in photometric communication with the dome and configured to detect light emitted or reflected from the tissue sample.
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3.发明申请
公开(公告)号：WO2022150408A1
公开(公告)日：2022-07-14
申请号：PCT/US2022/011343
申请日：2022-01-05
Applicant: CYTOVERIS INC.
Inventor： PANDEY, Rishikesh , FOURNIER, David , CURRY, Patrick , KERSEY, Alan
IPC: A61B1/06
Abstract: A system and method for analyzing bladder tissue sample is provided that includes an excitation light source, a photodetector, an optical filter, and a system controller. The excitation light source produces excitation lights centered on a distinct wavelengths. At least one of the wavelengths produces autofluorescence emissions from one or more biomolecules, and at least one of the wavelengths produces diffuse reflectance signals. The photodetector detects at least one of the autofluorescence emissions or diffuse reflectance signals and produces signals representative thereof. The optical filter filters at least one of autofluorescence emissions or the diffuse reflectance signals. The system controller communicates with the system components and a memory storing instructions. The instructions cause the system controller to control the excitation light unit, receive and process the photodetector signals, produce a signal image, and analyze the tissue sample to determine the presence of detrusor muscle tissue.
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4.发明申请
公开(公告)号：WO2022020807A1
公开(公告)日：2022-01-27
申请号：PCT/US2021/043196
申请日：2021-07-26
Applicant: CYTOVERIS INC.
Inventor： KERSEY, Alan , FOURNIER, David , PANDEY, Rishikesh , ROOT, Gary
Abstract: A system and method for analyzing a sample using Raman spectral light includes a light source, a light detector, a narrow band pass filter and an analyzer. Within the system, excitation light is directed to interrogate the sample. The narrow band pass filter is positioned to receive Raman scattered light produced as a result of the interrogation. The light detector is positioned to receive the Raman scattered light that has passed through the at least one narrow band pass filter. The analyzer contains stored instructions that when executed cause the processor to a) control the light source; and b) process signals produced by the light detector to analyze the sample material, the signals representative of the intensity of the Raman scattered light received by the at least one light detector corresponding to one or more wavenumbers in a high wavenumber region of a Raman signal.
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Patent Agency Ranking5.发明申请
公开(公告)号：WO2021216740A1
公开(公告)日：2021-10-28
申请号：PCT/US2021/028438
申请日：2021-04-21
Applicant: CYTOVERIS INC.
Inventor： FOURNIER, David , PANDEY, Rishikesh
IPC: G01N21/33 , G01N21/3563 , G01N21/64 , G01N21/65 , G01J3/44
Abstract: A method and system of analyzing a resected tissue specimen is provided. The method includes: a) using an imaging system to image a tissue sample with excitation light configured to produce fluorescent emissions from the tissue sample, the imaging producing signals representative of the fluorescent emissions from the sample; b) determining a presence or an absence of at least one suspect tissue region on the tissue sample; c) determining a spatial location of said at least one suspect tissue region determined to be present on the tissue sample; d) using the imaging system to image the suspect tissue region at the determined spatial location with excitation light configured to produce Raman scattering from the sample, the imaging producing signals representative of the Raman scattering from sample; and e) analyzing the determined suspect tissue region using the signals representative of the Raman scattering from the sample.
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公开(公告)号：WO2020206420A1
公开(公告)日：2020-10-08
申请号：PCT/US2020/026864
申请日：2020-04-06
Applicant: CYTOVERIS INC.
Inventor： ZHENG, Guoan , KERSEY, Alan , PANDEY, Rishikesh , FOURNIER, David
Abstract: An apparatus and method for analyzing a tissue sample to provide depth-selective information includes at least one light source, collection light optics, and a light detector. The light source is configured to produce a light beam having one or more wavelengths of light that cause a tissue sample to produce Raman light signals upon interrogation of the tissue sample. The light beam is oriented to impinge on an exposed surface of the tissue sample at a point of incidence (POI), and oriented so that the light beam enters the tissue sample at an oblique angle relative to the exposed surface of the tissue sample. The collection light optics are configured to collect the Raman light signals emanating from the tissue sample at one or more predetermined lateral distances from the point of incidence. The light detector is configured to receive the Raman light signals from the collection light optics.
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7.发明公开
公开(公告)号：EP4274465A1
公开(公告)日：2023-11-15
申请号：EP22737065.7
申请日：2022-01-05
Applicant: Cytoveris Inc.
Inventor： PANDEY, Rishikesh , FOURNIER, David , CURRY, Patrick , KERSEY, Alan
IPC: A61B1/06
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公开(公告)号：EP4214487A1
公开(公告)日：2023-07-26
申请号：EP21791156.9
申请日：2021-09-17
Applicant: Cytoveris Inc.
Inventor： FOURNIER, David , PANDEY, Rishikesh
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9.发明公开
公开(公告)号：EP4185859A1
公开(公告)日：2023-05-31
申请号：EP21845952.7
申请日：2021-07-26
Applicant: Cytoveris Inc.
Inventor： KERSEY, Alan , FOURNIER, David , PANDEY, Rishikesh , ROOT, Gary
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