A SMART TISSUE CLASSIFICATION FRAMEWORK BASED ON MULTI-CLASSIFIER SYSTEMS

    公开(公告)号:WO2022261106A1

    公开(公告)日:2022-12-15

    申请号:PCT/US2022/032516

    申请日:2022-06-07

    Applicant: CYTOVERIS INC.

    Abstract: A method and system of analyzing an ex-vivo tissue sample is provided. The method includes interrogating the tissue sample a plurality of times, each interrogation using at least one excitation light centered on a wavelength distinct from the others, at least one excitation light produces AF emissions from one or more biomolecules associated with the tissue sample, and another is produces diffuse reflectance signals from the tissue sample; b) using a photodetector to detect the AF emissions or diffuse reflectance signals from the tissue sample, producing photodetector signals representative thereof; c) processing the photodetector signals attributable to the AF emissions using a first trained classifier to determine first data sets indicative of biomolecules; d) processing the photodetector signals attributable to the diffuse reflectance signals using a second trained classifier to determine one or more second data sets; and e) determining a type of the tissue sample.

    SPECTROMETER-LESS SAMPLE ANALYSIS SYSTEM AND METHOD USING HIGH WAVENUMBER RAMAN SCATTERING

    公开(公告)号:WO2022020807A1

    公开(公告)日:2022-01-27

    申请号:PCT/US2021/043196

    申请日:2021-07-26

    Applicant: CYTOVERIS INC.

    Abstract: A system and method for analyzing a sample using Raman spectral light includes a light source, a light detector, a narrow band pass filter and an analyzer. Within the system, excitation light is directed to interrogate the sample. The narrow band pass filter is positioned to receive Raman scattered light produced as a result of the interrogation. The light detector is positioned to receive the Raman scattered light that has passed through the at least one narrow band pass filter. The analyzer contains stored instructions that when executed cause the processor to a) control the light source; and b) process signals produced by the light detector to analyze the sample material, the signals representative of the intensity of the Raman scattered light received by the at least one light detector corresponding to one or more wavenumbers in a high wavenumber region of a Raman signal.

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