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1.发明申请
公开(公告)号：WO2023278673A1
公开(公告)日：2023-01-05
申请号：PCT/US2022/035686
申请日：2022-06-30
Applicant: CYTOVERIS INC.
Inventor： FOURNIER, David , KERSEY, Alan
IPC: G02B21/00 , G02B21/16 , G02B21/08 , G02B21/06 , G02B21/361
Abstract: A system and method for imaging a tissue sample is provided. The system includes a dome, at least one excitation light source, and at least one light detector. The dome is configured to surround at least a portion of a tissue sample. The dome has interior surfaces that define a dome interior cavity. The excitation light source is configured to produce light at one or more wavelengths. The excitation light source is in photometric communication with the dome. The dome interior surfaces are configured to reflect the light at the one or more predetermined wavelengths. The dome is configured to cause the light at the one or more predetermined wavelengths to be incident to the exposed surface of the tissue sample in a substantially uniform manner. The light detector is in photometric communication with the dome and configured to detect light emitted or reflected from the tissue sample.
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2.发明公开
公开(公告)号：EP3917382A1
公开(公告)日：2021-12-08
申请号：EP20747693.8
申请日：2020-01-31
Applicant: Cytoveris Inc.
Inventor： KERSEY, Alan , PANDEY, Rishikesh
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公开(公告)号：WO2022261106A1
公开(公告)日：2022-12-15
申请号：PCT/US2022/032516
申请日：2022-06-07
Applicant: CYTOVERIS INC.
Inventor： PANDEY, Rishikesh , KERSEY, Alan , ROOT, Gary , SHIRVALKAR, Aditya
Abstract: A method and system of analyzing an ex-vivo tissue sample is provided. The method includes interrogating the tissue sample a plurality of times, each interrogation using at least one excitation light centered on a wavelength distinct from the others, at least one excitation light produces AF emissions from one or more biomolecules associated with the tissue sample, and another is produces diffuse reflectance signals from the tissue sample; b) using a photodetector to detect the AF emissions or diffuse reflectance signals from the tissue sample, producing photodetector signals representative thereof; c) processing the photodetector signals attributable to the AF emissions using a first trained classifier to determine first data sets indicative of biomolecules; d) processing the photodetector signals attributable to the diffuse reflectance signals using a second trained classifier to determine one or more second data sets; and e) determining a type of the tissue sample.
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4.发明申请
公开(公告)号：WO2022150408A1
公开(公告)日：2022-07-14
申请号：PCT/US2022/011343
申请日：2022-01-05
Applicant: CYTOVERIS INC.
Inventor： PANDEY, Rishikesh , FOURNIER, David , CURRY, Patrick , KERSEY, Alan
IPC: A61B1/06
Abstract: A system and method for analyzing bladder tissue sample is provided that includes an excitation light source, a photodetector, an optical filter, and a system controller. The excitation light source produces excitation lights centered on a distinct wavelengths. At least one of the wavelengths produces autofluorescence emissions from one or more biomolecules, and at least one of the wavelengths produces diffuse reflectance signals. The photodetector detects at least one of the autofluorescence emissions or diffuse reflectance signals and produces signals representative thereof. The optical filter filters at least one of autofluorescence emissions or the diffuse reflectance signals. The system controller communicates with the system components and a memory storing instructions. The instructions cause the system controller to control the excitation light unit, receive and process the photodetector signals, produce a signal image, and analyze the tissue sample to determine the presence of detrusor muscle tissue.
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5.发明申请
公开(公告)号：WO2022020807A1
公开(公告)日：2022-01-27
申请号：PCT/US2021/043196
申请日：2021-07-26
Applicant: CYTOVERIS INC.
Inventor： KERSEY, Alan , FOURNIER, David , PANDEY, Rishikesh , ROOT, Gary
Abstract: A system and method for analyzing a sample using Raman spectral light includes a light source, a light detector, a narrow band pass filter and an analyzer. Within the system, excitation light is directed to interrogate the sample. The narrow band pass filter is positioned to receive Raman scattered light produced as a result of the interrogation. The light detector is positioned to receive the Raman scattered light that has passed through the at least one narrow band pass filter. The analyzer contains stored instructions that when executed cause the processor to a) control the light source; and b) process signals produced by the light detector to analyze the sample material, the signals representative of the intensity of the Raman scattered light received by the at least one light detector corresponding to one or more wavenumbers in a high wavenumber region of a Raman signal.
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2021155375A1
公开(公告)日：2021-08-05
申请号：PCT/US2021/016090
申请日：2021-02-01
Applicant: CYTOVERIS INC.
Inventor： KERSEY, Alan , PANDEY, Rishikesh , CURRY, Patrick
Abstract: A method and system for determining the presence of a mass of cancerous cells in vivo within a tissue body is provided. The method includes: a) performing an examination of the tissue body using a diagnostic method operable to determine the presence of a suspect tissue mass, and determining a location of the same; b) administering a solution containing "RR-CTEs", the RR-CTEs configured to target and bind with cancerous cells; c) interrogating the tissue body with a beam of light, wherein the RR-CTEs are configured to produce Raman scattered light upon impingement; d) collecting the Raman scattered light; e) processing the collected Raman scattered light to determine a presence or an absence of the a Raman signature; and f) comparing the determined location of the suspect tissue mass with the determined location of the mass of cancerous cells to determine the presence of the mass of cancerous cells.
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7.发明申请
公开(公告)号：WO2021011823A1
公开(公告)日：2021-01-21
申请号：PCT/US2020/042415
申请日：2020-07-16
Applicant: CYTOVERIS INC.
Inventor： KERSEY, Alan , PANDEY, Rishikesh
Abstract: A system and method for mapping a tissue sample is provided. The system includes a light source, a scanner, a digital mirror device (DMD), a light detector, and an analyzer. The DMD has an array of micromirrors. The analyzer controls the light source, controls the scanner, controls the DMD to have on-state micromirrors aligned with a light beam, and other micromirrors in an off-state. The on-state micromirrors direct the light beam to a tissue sample. The analyzer assigns one or more location codes to the on-state micromirrors, controls the light detector to receive Raman light emitted from the tissue sample, correlates the location codes of the on-state micromirrors with light detector signals representative of the Raman emitted light, and produces a spatial map of the Raman emitted light.
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公开(公告)号：WO2020206420A1
公开(公告)日：2020-10-08
申请号：PCT/US2020/026864
申请日：2020-04-06
Applicant: CYTOVERIS INC.
Inventor： ZHENG, Guoan , KERSEY, Alan , PANDEY, Rishikesh , FOURNIER, David
Abstract: An apparatus and method for analyzing a tissue sample to provide depth-selective information includes at least one light source, collection light optics, and a light detector. The light source is configured to produce a light beam having one or more wavelengths of light that cause a tissue sample to produce Raman light signals upon interrogation of the tissue sample. The light beam is oriented to impinge on an exposed surface of the tissue sample at a point of incidence (POI), and oriented so that the light beam enters the tissue sample at an oblique angle relative to the exposed surface of the tissue sample. The collection light optics are configured to collect the Raman light signals emanating from the tissue sample at one or more predetermined lateral distances from the point of incidence. The light detector is configured to receive the Raman light signals from the collection light optics.
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9.发明公开
公开(公告)号：EP4274465A1
公开(公告)日：2023-11-15
申请号：EP22737065.7
申请日：2022-01-05
Applicant: Cytoveris Inc.
Inventor： PANDEY, Rishikesh , FOURNIER, David , CURRY, Patrick , KERSEY, Alan
IPC: A61B1/06
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10.发明公开
公开(公告)号：EP4185859A1
公开(公告)日：2023-05-31
申请号：EP21845952.7
申请日：2021-07-26
Applicant: Cytoveris Inc.
Inventor： KERSEY, Alan , FOURNIER, David , PANDEY, Rishikesh , ROOT, Gary
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