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公开(公告)号：WO2022061186A1
公开(公告)日：2022-03-24
申请号：PCT/US2021/050991
申请日：2021-09-17
Applicant: CYTOVERIS INC.
Inventor： FOURNIER, David , PANDEY, Rishikesh
Abstract: A method and system for analyzing a tissue sample is provided. The method includes: a) sequentially interrogating a tissue sample with excitation lights, wherein at least one of the excitation lights is configured to produce autofluorescence emissions from one or more biomolecules of interest, and diffuse reflectance signals from the tissue sample; b) using a photodetector to detect the autofluorescence emissions and/or the diffuse reflectance signals from the tissue sample, and to produce photodetector signals representative of the detected said autofluorescence emissions and/or the detected said diffuse reflectance signals; c) filtering the light emitted or reflected from the tissue sample; d) processing the photodetector signals for each sequential application of excitation light, including producing an image representative of the photodetector signals produced by each sequential application of excitation light; and e) analyzing the tissue sample using each image to identify the presence of diseased tissue within the tissue sample.
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2.发明申请
公开(公告)号：WO2023278673A1
公开(公告)日：2023-01-05
申请号：PCT/US2022/035686
申请日：2022-06-30
Applicant: CYTOVERIS INC.
Inventor： FOURNIER, David , KERSEY, Alan
IPC: G02B21/00 , G02B21/16 , G02B21/08 , G02B21/06 , G02B21/361
Abstract: A system and method for imaging a tissue sample is provided. The system includes a dome, at least one excitation light source, and at least one light detector. The dome is configured to surround at least a portion of a tissue sample. The dome has interior surfaces that define a dome interior cavity. The excitation light source is configured to produce light at one or more wavelengths. The excitation light source is in photometric communication with the dome. The dome interior surfaces are configured to reflect the light at the one or more predetermined wavelengths. The dome is configured to cause the light at the one or more predetermined wavelengths to be incident to the exposed surface of the tissue sample in a substantially uniform manner. The light detector is in photometric communication with the dome and configured to detect light emitted or reflected from the tissue sample.
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公开(公告)号：US20240210321A1
公开(公告)日：2024-06-27
申请号：US18567981
申请日：2022-06-07
Applicant: CytoVeris Inc.
Inventor： Rishikesh Pandey , Alan Kersey , Gary Root , Aditya Shirvalkar
IPC: G01N21/64
CPC classification number: G01N21/6486 , G01N21/645 , G01N2021/6417 , G01N2201/1296
Abstract: A method and system of analyzing an ex-vivo tissue sample is provided. The method includes interrogating the tissue sample a plurality of times, each interrogation using at least one excitation light centered on a wavelength distinct from the others, at least one excitation light produces AF emissions from one or more biomolecules associated with the tissue sample, and another is produces diffuse reflectance signals from the tissue sample; b) using a photodetector to detect the AF emissions or diffuse reflectance signals from the tissue sample, producing photodetector signals representative thereof; c) processing the photodetector signals attributable to the AF emissions using a first trained classifier to determine first data sets indicative of biomolecules; d) processing the photodetector signals attributable to the diffuse reflectance signals using a second trained classifier to determine one or more second data sets; and e) determining a type of the tissue sample.
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公开(公告)号：US20220283093A1
公开(公告)日：2022-09-08
申请号：US17688792
申请日：2022-03-07
Applicant: CytoVeris Inc.
Inventor： Rishikesh Pandey , Alan Kersey
Abstract: A method and system for classifying a tissue specimen is provided. The method includes: a) interrogating a tissue specimen with a first interrogation light; b) detecting first light from the tissue specimen resulting from the interrogation, wherein the first light includes a first scattered light component and a first fluorescence light component, and producing first signals; c) interrogating the tissue specimen with a second interrogation light at a second excitation wavelength, wherein the first and second excitation wavelengths are within about 2 nm of each other; d) detecting second light from the tissue specimen resulting from the interrogation, wherein the second light includes a second scattered light component and a second fluorescence light component, and producing second signals; e) determining a difference between the first and second lights; f) determining a fluorescence spectrum produced by the interrogation of the tissue specimen; and g) classifying the tissue specimen.
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公开(公告)号：US20220196557A1
公开(公告)日：2022-06-23
申请号：US17601631
申请日：2020-04-06
Applicant: CYTOVERIS INC.
Inventor： Guoan Zheng , Alan Kersey , Rishikesh Pandey , David Fournier
Abstract: An apparatus and method for analyzing a tissue sample to provide depth-selective information includes at least one light source, collection light optics, and a light detector. The light source is configured to produce a light beam having one or more wavelengths of light that cause a tissue sample to produce Raman light signals upon interrogation of the tissue sample. The light beam is oriented to impinge on an exposed surface of the tissue sample at a point of incidence (POI), and oriented so that the light beam enters the tissue sample at an oblique angle relative to the exposed surface of the tissue sample. The collection light optics are configured to collect the Raman light signals emanating from the tissue sample at one or more predetermined lateral distances from the point of incidence. The light detector is configured to receive the Raman light signals from the collection light optics.
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Patent Agency Ranking
公开(公告)号：US11193827B2
公开(公告)日：2021-12-07
申请号：US16868352
申请日：2020-05-06
Applicant: CytoVeris Inc.
Inventor： Alan Kersey
Abstract: A method and apparatus for determining a level of background fluorescent light produced during photometric interrogation of a sample is provided. The method includes applying an excitation light to a sample using a laser at a plurality linewidths different from one another, the excitation light at each of the plurality of different linewidths applied at an excitation wavelength operable to cause emission of light from the sample, the light emitted from the sample including Raman scattered light and background fluorescent light; detecting light emitted from the tissue sample at each of the plurality of linewidths using a detector and producing light signals representative of the detected light; and determining a level of the background fluorescent using the light signals representative of the detected light for each of the plurality of different linewidths.
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公开(公告)号：WO2022261106A1
公开(公告)日：2022-12-15
申请号：PCT/US2022/032516
申请日：2022-06-07
Applicant: CYTOVERIS INC.
Inventor： PANDEY, Rishikesh , KERSEY, Alan , ROOT, Gary , SHIRVALKAR, Aditya
Abstract: A method and system of analyzing an ex-vivo tissue sample is provided. The method includes interrogating the tissue sample a plurality of times, each interrogation using at least one excitation light centered on a wavelength distinct from the others, at least one excitation light produces AF emissions from one or more biomolecules associated with the tissue sample, and another is produces diffuse reflectance signals from the tissue sample; b) using a photodetector to detect the AF emissions or diffuse reflectance signals from the tissue sample, producing photodetector signals representative thereof; c) processing the photodetector signals attributable to the AF emissions using a first trained classifier to determine first data sets indicative of biomolecules; d) processing the photodetector signals attributable to the diffuse reflectance signals using a second trained classifier to determine one or more second data sets; and e) determining a type of the tissue sample.
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8.发明申请
公开(公告)号：WO2022150408A1
公开(公告)日：2022-07-14
申请号：PCT/US2022/011343
申请日：2022-01-05
Applicant: CYTOVERIS INC.
Inventor： PANDEY, Rishikesh , FOURNIER, David , CURRY, Patrick , KERSEY, Alan
IPC: A61B1/06
Abstract: A system and method for analyzing bladder tissue sample is provided that includes an excitation light source, a photodetector, an optical filter, and a system controller. The excitation light source produces excitation lights centered on a distinct wavelengths. At least one of the wavelengths produces autofluorescence emissions from one or more biomolecules, and at least one of the wavelengths produces diffuse reflectance signals. The photodetector detects at least one of the autofluorescence emissions or diffuse reflectance signals and produces signals representative thereof. The optical filter filters at least one of autofluorescence emissions or the diffuse reflectance signals. The system controller communicates with the system components and a memory storing instructions. The instructions cause the system controller to control the excitation light unit, receive and process the photodetector signals, produce a signal image, and analyze the tissue sample to determine the presence of detrusor muscle tissue.
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9.发明申请
公开(公告)号：WO2022020807A1
公开(公告)日：2022-01-27
申请号：PCT/US2021/043196
申请日：2021-07-26
Applicant: CYTOVERIS INC.
Inventor： KERSEY, Alan , FOURNIER, David , PANDEY, Rishikesh , ROOT, Gary
Abstract: A system and method for analyzing a sample using Raman spectral light includes a light source, a light detector, a narrow band pass filter and an analyzer. Within the system, excitation light is directed to interrogate the sample. The narrow band pass filter is positioned to receive Raman scattered light produced as a result of the interrogation. The light detector is positioned to receive the Raman scattered light that has passed through the at least one narrow band pass filter. The analyzer contains stored instructions that when executed cause the processor to a) control the light source; and b) process signals produced by the light detector to analyze the sample material, the signals representative of the intensity of the Raman scattered light received by the at least one light detector corresponding to one or more wavenumbers in a high wavenumber region of a Raman signal.
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公开(公告)号：US20230366795A1
公开(公告)日：2023-11-16
申请号：US18196411
申请日：2023-05-11
Applicant: CytoVeris Inc.
Inventor： Morgan McNamara , David Fournier , Noel Diagneault , Michael A. Sapack , Gary Root
CPC classification number: G01N1/36 , A61B90/39 , A61B90/90 , A61B2090/3937 , B01L2200/141 , B01L2300/123 , B01L2300/041 , B01L2300/021 , B01L2300/12
Abstract: An apparatus for holding a tissue specimen during imaging is provided. The tissue specimen has a 3D geometry and a region of interest. The apparatus includes a cover panel and a specimen support structure. The cover panel has upper and bottom panel surfaces and a viewing aperture that extends between the upper and bottom panel surfaces. The specimen support structure is configured to support the tissue specimen in an imaging orientation. The specimen support structure is configured to permit alignment of the tissue specimen ROI with the viewing aperture. The apparatus is configurable in a secured configuration in which the specimen support structure is positionally fixed relative to the cover panel, the tissue specimen ROI is exposed through the viewing aperture for imaging, and the tissue specimen ROI is held motionless relative to the cover panel.
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