公开(公告)号：FI72313C

公开(公告)日：1987-05-11

申请号：FI822398

申请日：1982-07-06

Applicant: DEGUSSA

Inventor： BETHGE HORST ,  KLEEMAN AXEL ,  MARTENS JUERGEN

IPC: C07B57/00 ,  A61K31/195 ,  C07B31/00 ,  C07C20060101 ,  C07C67/00 ,  C07C313/00 ,  C07C319/28 ,  C07C323/58 ,  C07C149/243 ,  C07C148/04 ,  C07C87/28

公开(公告)号：FI840688A

公开(公告)日：1984-09-12

申请号：FI840688

申请日：1984-02-20

Applicant: DEGUSSA

Inventor： DRAUZ KARLHEINZ ,  KLEEMAN AXEL

IPC: C07C27/00 ,  C07C37/60 ,  C07C39/08 ,  C07C67/00 ,  C07C

公开(公告)号：FI72313B

公开(公告)日：1987-01-30

申请号：FI822398

申请日：1982-07-06

Applicant: DEGUSSA

Inventor： BETHGE HORST ,  KLEEMAN AXEL ,  MARTENS JUERGEN

IPC: C07B57/00 ,  A61K31/195 ,  C07B31/00 ,  C07C20060101 ,  C07C67/00 ,  C07C313/00 ,  C07C319/28 ,  C07C323/58 ,  C07C149/243 ,  C07C148/04 ,  C07C87/28

Abstract: There is described the resolution of the racemate S-(carboxymethyl)-(RS)-cysteine. It is carried out by means of the optical isomers of 1-phenyl-ethylamine. This process makes it possible to obtain in a simple manner S-(carboxymethyl)-(R)-cysteine which is important for pharmaceutical purposes and is made from synthetically produced cysteine.

公开(公告)号：FI840692A

公开(公告)日：1984-09-12

申请号：FI840692

申请日：1984-02-20

Applicant: DEGUSSA

Inventor： DRAUZ KARLHEINZ ,  KLEEMAN AXEL

IPC: B01J27/00 ,  B01J27/02 ,  C07B61/00 ,  C07C27/00 ,  C07C37/60 ,  C07C39/08 ,  C07C67/00 ,  C07C

公开(公告)号：FI840691A

公开(公告)日：1984-09-12

申请号：FI840691

申请日：1984-02-20

Applicant: DEGUSSA

Inventor： DRAUZ KARLHEINZ ,  KLEEMAN AXEL ,  WIRTHWEIN ROLF

IPC: C01B15/017 ,  C01B

公开(公告)号：FI840691A0

公开(公告)日：1984-02-20

申请号：FI840691

申请日：1984-02-20

Applicant: DEGUSSA

Inventor： DRAUZ KARLHEINZ ,  KLEEMAN AXEL ,  WIRTHWEIN ROLF

IPC: C01B15/017 ,  C01B

公开(公告)号：FI822397L

公开(公告)日：1983-03-01

申请号：FI822397

申请日：1982-07-06

Applicant: DEGUSSA

Inventor： BETHGE HORST ,  KLEEMAN AXEL ,  MARTENS JYRGEN

IPC: A61K31/195 ,  C07C319/28 ,  C07B57/00 ,  C07C20060101 ,  C07C67/00 ,  C07C313/00 ,  C07C323/58 ,  C07C

Abstract: There is described the resolution of the racemate S-(carboxymethyl)-(RS)-cysteine. It is carried out by means of the optical isomers of 2-amino-1-phenyl-propan-1-ol. This process makes it possible to obtain in a simple manner S-(carboxymethyl)-(R)-cysteine which is important for pharmaceutical purposes and is made from synthetically produced cysteine.

公开(公告)号：BR8200882A

公开(公告)日：1982-12-28

申请号：BR8200882

申请日：1982-02-18

Applicant: DEGUSSA

Inventor： KLEEMAN AXEL ,  LEUCHTENBERGER WOLFGANG ,  SCHWARZE WERNER

IPC: C07D253/06 ,  A01N43/64 ,  C07C255/45 ,  C07D253/075

公开(公告)号：FI780083A

公开(公告)日：1978-07-13

申请号：FI780083

申请日：1978-01-11

Applicant: DEGUSSA

Inventor： KLEEMAN AXEL ,  NUBERT INGOMAR ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: C07D333/24 ,  A61K31/38 ,  A61K31/381 ,  A61P9/08 ,  C07D333/16 ,  C07D333/20 ,  C07D

Abstract: There are prepared compounds of the formula (I) where >A-B- has either the structure >C(OH)-CH2- or the structure >C=CH, Alk is a straight or branched chain C1-C5-alkylene group and Y is where R is hydrogen or a C1-C4-alkyl group and T is hydrogen or a C2-C6-alkanoyl group where R' is hydrogen, phenyl, phenyl substituted once or twice. The compounds are effective in improving peripheral and cerebral circulation. There are also produced intermediate compounds of formula (II) where NHY is replaced by chlorine, bromine or iodine.

公开(公告)号：BR8706807A

公开(公告)日：1988-07-19

申请号：BR8706807

申请日：1987-12-15

Applicant: DEGUSSA

Inventor： DRAUZ KARL-HEINZ ,  KLEEMAN AXEL ,  PRESCHER GUNTER ,  RITTER GEBHARD

IPC: B01J27/02 ,  C07B31/00 ,  C07B41/02 ,  C07B61/00 ,  C07C27/00 ,  C07C37/60 ,  C07C39/08 ,  C07C41/00 ,  C07C41/26 ,  C07C43/23 ,  C07C67/00

Abstract: The nuclear hydroxylation of substituted phenols is performed by using aqueous hydrogen peroxide in the presence of sulfur dioxide or selenium dioxide as catalyst in a simple manner with very good space-time yields and good product yields.