公开(公告)号：DD136265A5

公开(公告)日：1979-06-27

申请号：DD20315978

申请日：1978-01-10

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  NUBERT INGOMAR ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: C07D333/24 ,  A61K31/38 ,  A61K31/381 ,  A61P9/08 ,  C07D333/16 ,  C07D333/20

Abstract: There are prepared compounds of the formula (I) where >A-B- has either the structure >C(OH)-CH2- or the structure >C=CH, Alk is a straight or branched chain C1-C5-alkylene group and Y is where R is hydrogen or a C1-C4-alkyl group and T is hydrogen or a C2-C6-alkanoyl group where R' is hydrogen, phenyl, phenyl substituted once or twice. The compounds are effective in improving peripheral and cerebral circulation. There are also produced intermediate compounds of formula (II) where NHY is replaced by chlorine, bromine or iodine.

公开(公告)号：AU522750B2

公开(公告)日：1982-06-24

申请号：AU3239278

申请日：1978-01-12

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  NUBERT INGOMAR ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: C07D333/24 ,  A61K31/38 ,  A61K31/381 ,  A61P9/08 ,  C07D333/16 ,  C07D333/20 ,  A61K31/495 ,  A61K31/535 ,  C07D409/12 ,  C07D413/12

Abstract: There are prepared compounds of the formula (I) where >A-B- has either the structure >C(OH)-CH2- or the structure >C=CH, Alk is a straight or branched chain C1-C5-alkylene group and Y is where R is hydrogen or a C1-C4-alkyl group and T is hydrogen or a C2-C6-alkanoyl group where R' is hydrogen, phenyl, phenyl substituted once or twice. The compounds are effective in improving peripheral and cerebral circulation. There are also produced intermediate compounds of formula (II) where NHY is replaced by chlorine, bromine or iodine.

公开(公告)号：HU177978B

公开(公告)日：1982-02-28

申请号：HUDE001033

申请日：1978-01-11

Applicant: DEGUSSA

Inventor： KELEMENN AXEL ,  NUBERT INGOMAR ,  STROMANN FRITZ ,  THIEMER KLAUS

IPC: C07D333/24 ,  A61K31/38 ,  A61K31/381 ,  A61P9/08 ,  C07D333/16 ,  C07D333/20 ,  C07D333/10

Abstract: There are prepared compounds of the formula (I) where >A-B- has either the structure >C(OH)-CH2- or the structure >C=CH, Alk is a straight or branched chain C1-C5-alkylene group and Y is where R is hydrogen or a C1-C4-alkyl group and T is hydrogen or a C2-C6-alkanoyl group where R' is hydrogen, phenyl, phenyl substituted once or twice. The compounds are effective in improving peripheral and cerebral circulation. There are also produced intermediate compounds of formula (II) where NHY is replaced by chlorine, bromine or iodine.

公开(公告)号：NO823010L

公开(公告)日：1978-07-13

申请号：NO823010

申请日：1982-09-06

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  NUBERT INGOMAR ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: C07D20060101 ,  C07D

公开(公告)号：DE2800535A1

公开(公告)日：1978-07-13

申请号：DE2800535

申请日：1978-01-07

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL DR ,  NUBERT INGOMAR ,  STROMAN FRITZ DR ,  THIEMER KLAUS DR

IPC: C07D333/24 ,  A61K31/38 ,  A61K31/381 ,  A61P9/08 ,  C07D333/16 ,  C07D333/20 ,  C07D409/14

Abstract: There are prepared compounds of the formula (I) where >A-B- has either the structure >C(OH)-CH2- or the structure >C=CH, Alk is a straight or branched chain C1-C5-alkylene group and Y is where R is hydrogen or a C1-C4-alkyl group and T is hydrogen or a C2-C6-alkanoyl group where R' is hydrogen, phenyl, phenyl substituted once or twice. The compounds are effective in improving peripheral and cerebral circulation. There are also produced intermediate compounds of formula (II) where NHY is replaced by chlorine, bromine or iodine.

公开(公告)号：HU178208B

公开(公告)日：1982-03-28

申请号：HUDE000949

申请日：1978-01-11

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  NUBERT INGOMAR ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: C07D333/24 ,  A61K31/38 ,  A61K31/381 ,  A61P9/08 ,  C07D333/16 ,  C07D333/20 ,  C07D409/06

Abstract: There are prepared compounds of the formula (I) where >A-B- has either the structure >C(OH)-CH2- or the structure >C=CH, Alk is a straight or branched chain C1-C5-alkylene group and Y is where R is hydrogen or a C1-C4-alkyl group and T is hydrogen or a C2-C6-alkanoyl group where R' is hydrogen, phenyl, phenyl substituted once or twice. The compounds are effective in improving peripheral and cerebral circulation. There are also produced intermediate compounds of formula (II) where NHY is replaced by chlorine, bromine or iodine.

公开(公告)号：SU784774A3

公开(公告)日：1980-11-30

申请号：SU2564303

申请日：1978-01-11

Applicant: DEGUSSA

Inventor： KLEEMANN AKSEL ,  KIL RAJNKHOLD ,  NUBERT INGOMAR

IPC: A61K31/382 ,  C07D333/16 ,  C07D333/14 ,  C07D333/20 ,  A61K31/38

Abstract: [1,1-dithien-(3)-yl-1-hydroxy-(3)-propyl]-[1-phenyl-1-hydroxy-(2)-prop yl]-amine is prepared by condensing thien-(3)-yl lithium with a beta -halogen propionic acid alkyl ester of the formula (II) where R is a lower alkyl group and Hal is chlorine, bromine or iodine, in an inert medium at a temperature below -50 DEG C. to form a compound of the formula (III) which is then reacted with 2-amino-1-hydroxy-1-phenylpropane in an inert medium in the presence of a basic compound. The product cn be converted to [1,1-dithien-(3)-yl-(1)-propen-(3)-yl]-[1-phenyl-(2)-propyl]-amine by dehydration.

公开(公告)号：DD142883A5

公开(公告)日：1980-07-16

申请号：DD21212778

申请日：1978-01-10

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  NUBERT INGOMAR ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: C07D333/24 ,  A61K31/38 ,  A61K31/381 ,  A61P9/08 ,  C07D333/16 ,  C07D333/20 ,  C07D409/06

Abstract: There are prepared compounds of the formula (I) where >A-B- has either the structure >C(OH)-CH2- or the structure >C=CH, Alk is a straight or branched chain C1-C5-alkylene group and Y is where R is hydrogen or a C1-C4-alkyl group and T is hydrogen or a C2-C6-alkanoyl group where R' is hydrogen, phenyl, phenyl substituted once or twice. The compounds are effective in improving peripheral and cerebral circulation. There are also produced intermediate compounds of formula (II) where NHY is replaced by chlorine, bromine or iodine.

公开(公告)号：NO780100A

公开(公告)日：1978-07-13

申请号：NO780100

申请日：1978-01-11

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  KIEL REINHOLD ,  NUBERT INGOMAR

IPC: C07D333/14 ,  A61K31/382 ,  C07D333/16 ,  C07D333/20 ,  C07D

CPC classification number: C07D333/16 ,  C07D333/20

公开(公告)号：HU175896B

公开(公告)日：1980-11-28

申请号：HUDE000950

申请日：1978-01-11

Applicant: DEGUSSA

Inventor： KLEEMANN ALEX ,  KIEL REINHOLD ,  NUBERT INGOMAR

IPC: C07D333/14 ,  A61K31/382 ,  C07D333/16 ,  C07D333/20

Abstract: [1,1-dithien-(3)-yl-1-hydroxy-(3)-propyl]-[1-phenyl-1-hydroxy-(2)-prop yl]-amine is prepared by condensing thien-(3)-yl lithium with a beta -halogen propionic acid alkyl ester of the formula (II) where R is a lower alkyl group and Hal is chlorine, bromine or iodine, in an inert medium at a temperature below -50 DEG C. to form a compound of the formula (III) which is then reacted with 2-amino-1-hydroxy-1-phenylpropane in an inert medium in the presence of a basic compound. The product cn be converted to [1,1-dithien-(3)-yl-(1)-propen-(3)-yl]-[1-phenyl-(2)-propyl]-amine by dehydration.