公开(公告)号：JP2000086626A

公开(公告)日：2000-03-28

申请号：JP25453699

申请日：1999-09-08

Applicant: DEGUSSA

Inventor： DRAUZ KARLHEINZ ,  KLEMENT INGO DR ,  KNAUP GUENTER

IPC: C07C321/14 ,  C07C323/60 ,  C07C381/12 ,  C07D207/26 ,  C07D207/273

Abstract: PROBLEM TO BE SOLVED: To obtain a γ-lactam useful as an intermediate for producing physiologically actively acting substances in an industrial scale by cyclizing a specific derivative, while avoiding the employment of a dangerous substance and an expensive reagent as much as possible. SOLUTION: This method for producing a γ-lactam of formula II comprises cyclizing a derivative of formula I [R1, R2 are each H, a (substituted) 1-8C alkyl, a 2-8C alkenyl, a 2-8C alkynyl or the like; R3 is H, a 1-8C acyl, a C- bonded amino acid group or the like; Y is a 1-4C alkyl, a 1-8C (substituted) alkylene or the like]. The reaction is preferably carried out under a basic condition such as potassium hydroxide or potassium hydroxide in a polar protonic solvent such as methanol in a temperature range of 0-150 deg.C.

公开(公告)号：JP2000143684A

公开(公告)日：2000-05-26

申请号：JP17101999

申请日：1999-06-17

Applicant: DEGUSSA

Inventor： KNOCHEL PAUL ,  ALMENA PEREA JUAN JOSE DR ,  DRAUZ KARLHEINZ ,  KLEMENT INGO DR

IPC: B01J31/24 ,  C07B53/00 ,  C07C51/36 ,  C07C67/303 ,  C07C67/31 ,  C07F17/02

Abstract: PROBLEM TO BE SOLVED: To obtain a correspondingly hydrogen added derivative in remarkably good yield and in high e e value by using the subject ligand and complex in enantioselectively adding hydrogen to a multiple bond by a homogeneous catalyst. SOLUTION: A ligand enriched in an enantiomer expressed by formula I (R1 to R3 are each H, a 1-8C alkyl, a 1-8C alkoxy or the like; R4 is a 1-8C alkyl or a 6-18C aryl; R5 is H or the like) or its salt is used. As the ligand of formula I, e.g. (αR, α'R)-2, 2'-bis(α-N,N-dimethylaminophenylmethyl)-(S,S)-1,1'- bis(diphenylphosphino)-ferrocene is cited. A complex enriched in an enantiomer expressed by formula II and its salt can be used. The ligand of formula I is obtained by using ferrocene, acetyl chloride and AlCl3 as raw materials by a method publicly known.

公开(公告)号：JP2002179634A

公开(公告)日：2002-06-26

申请号：JP2001347947

申请日：2001-11-13

Applicant: DEGUSSA

Inventor： EILS STEFAN ,  ROSSEN KAI ,  JAHN WILFRIED ,  KLEMENT INGO DR

IPC: C07C249/02 ,  C07C251/08 ,  C07C251/24

Abstract: PROBLEM TO BE SOLVED: To provide a new method for manufacturing N-methyleneglycinate. SOLUTION: This method comprises manufacturing N-methyleneglycinate of formula I (wherein, R1 and R2 are independent from each other, and they are each an alkyl, an alkoxyalkyl, an aryl, an aralkyl, a heteroaryl, a heteroaralkyl, an alkylaryl, an alkylheteroaryl, a cycloalkyl, an alkylcycloalkyl and a cycloalkylalkyl; and R3 is an alkyl, an alkoxyalkyl, an aryl, an aralkyl, a cycloalkyl and an alkylcycloalkyl) through nucleophilic substitution with an imine and a corresponding acetic acid derivative. The method can easily produce N-methyleneglycinate in extremely high yield and with extremely high purity.

公开(公告)号：JP2001288218A

公开(公告)日：2001-10-16

申请号：JP2001013677

申请日：2001-01-22

Applicant: DEGUSSA

Inventor： KRIMMER HANS-PETER ,  WOELTINGER JENS ,  BURKHARDT OLAF DR ,  KLEMENT INGO DR ,  HENNIGES HANS ,  DRAUZ KARLHEINZ ,  BOMMARIUS ANDREAS ,  PHILIPPE JEAN-LOUIS ,  KARAU ANDREAS

IPC: C07D263/10 ,  B01J31/18 ,  B01J31/22 ,  B01J31/24 ,  C07B53/00 ,  C07D207/08 ,  C07D207/16 ,  C07D209/52 ,  C07D263/28 ,  C07D413/14 ,  C08F8/30 ,  C08F8/40 ,  C08F30/00 ,  C08G85/00

Abstract: PROBLEM TO BE SOLVED: To provide a ligand separable between a product and a catalyst relating to a membrane used and other ligands relating to the catalyst for the purpose of excluding problems that the catalyst is deactivated accompanying reaction progress. SOLUTION: In such case of a homogeneous soluble ligand having increased molecular weight for a hydrogenation catalyst having a homochiral active center, a specific linker may be inserted between the active center and a polymer skeleton, further the ligand is transferred into the catalyst and preferably may be used just like continuously or continuously in a membrane type reactor for an organic synthesis.

公开(公告)号：JP2000053593A

公开(公告)日：2000-02-22

申请号：JP17017599

申请日：1999-06-16

Applicant: DEGUSSA

Inventor： KNOCHEL PAUL ,  ALMENA PEREA JUAN JOSE DR ,  DRAUZ KARLHEINZ ,  KLEMENT INGO DR

IPC: B01J31/24 ,  C07B53/00 ,  C07B61/00 ,  C07C51/36 ,  C07C51/367 ,  C07C59/48 ,  C07C67/303 ,  C07C67/31 ,  C07C69/732 ,  C07C227/18 ,  C07C229/36

Abstract: PROBLEM TO BE SOLVED: To hydrogenate an ester component or an acid compound in an enantioselective state by using a specific ferrocenyl catalyst. SOLUTION: A compound of formula I [(n) is an integer of 1-3; R is H, a 1-18C alkyl, a 6-18C aryl, a 7-19C aralkyl, a carboxy-protecting group or the like; R' is H, a 1-18C alkyl, a 6-18C aryl, a 7-19C aralkyl or the like; X is 0, CHR", NR" or the like; R" is H, OH, R', a 1-18C alkoxy or the like] is hydrogenated in the presence of a homogeneous catalyst of formula II [R1 and R2 are each H, a 1-18C alkyl, a 1-18C alkoxy or the like; R3 is a 2-18C alkyl, a 1-18C alkoxy or the like; R4 is a 1-18C alkyl, a 6-18C aryl or the like; R5 is H or the like; R6 and R7 are each H, a 1-18C alkyl, a 1-18C alkoxy, a 1-18C acyl or the like; R8 is H or a 1-18C alkyl; M is a sub-group 7 or 8 metal atom such as Co, Ni, Rh or Ru or the ion of the metal) in an enantio-selective state.

公开(公告)号：DK0985665T3

公开(公告)日：2003-03-17

申请号：DK99116580

申请日：1999-08-25

Applicant: DEGUSSA

Inventor： DRAUZ KARLHEINZ PROF ,  KLEMENT INGO DR ,  KNAUP GUENTER DR

IPC: C07C321/14 ,  C07C323/60 ,  C07C381/12 ,  C07D207/26 ,  C07D207/273

Abstract: 3-Amino-2-pyrrolidinone derivatives (I) and their salts are produced the cyclization of a S-substituted methionine derivative (II). The S-substituted methionine (II) are new. Production of 3-amino-2-pyrrolidinone derivatives (I) and their salts comprises the cyclization of a S-substituted methionine derivative (II): R1 = H; alkyl, alkenyl, alkoxyalkyl or acyl optionally substituted with halo or groups containing N, O, P or S; cycloalkyl optionally unsaturated, optionally substituted with alkyl, alkenyl, acyl, alkoxy, alkoxyalkyl, halo or groups containing N, O, P or S and optionally containing ring hetero atoms; aryl, aralkyl, heteroaryl or heteroaralkyl optionally ring-substituted with alkyl, alkenyl, alkynyl, acyl, alkoxy, alkoxyalkyl, halo, CN, CONH2 or groups containing N, O, P or S; or a N-bonded amino acid or peptide group; R2 = H; alkyl, alkenyl, alkynyl or alkoxyalkyl optionally substituted with halo or groups containing N, O, P or S; cycloalkyl optionally unsaturated, optionally substituted with alkyl, alkenyl, acyl, alkoxy, alkoxyalkyl, halo or groups containing N, O, P or S and/or optionally containing ring hetero atoms; aryl, aralkyl, heteroaryl or heteroaralkyl optionally ring-substituted with alkyl, alkenyl, alkynyl, acyl, alkoxy, alkoxyalkyl, halo or groups containing N, O, P or S; R3 = H; acyl; a C-bonded amino acid or peptide group; or a peptide protecting group; and Y = alkylene optionally substituted with alkyl, halo, OH or phenyl; or aralkyl optionally substituted with alkyl, halo or OH. The full definitions are given in the DEFINITIONS (Full Definitions) Field. Independent claims are also included for the following: (1) S-substituted methionine derivatives of formula (II) and their addition salts; and (2) preparation of compounds of formula (II).

公开(公告)号：AT229504T

公开(公告)日：2002-12-15

申请号：AT99116580

申请日：1999-08-25

Applicant: DEGUSSA

Inventor： DRAUZ KARLHEINZ PROF ,  KLEMENT INGO DR ,  KNAUP GUENTER DR

IPC: C07C321/14 ,  C07C323/60 ,  C07C381/12 ,  C07D207/26 ,  C07D207/273

Abstract: 3-Amino-2-pyrrolidinone derivatives (I) and their salts are produced the cyclization of a S-substituted methionine derivative (II). The S-substituted methionine (II) are new. Production of 3-amino-2-pyrrolidinone derivatives (I) and their salts comprises the cyclization of a S-substituted methionine derivative (II): R1 = H; alkyl, alkenyl, alkoxyalkyl or acyl optionally substituted with halo or groups containing N, O, P or S; cycloalkyl optionally unsaturated, optionally substituted with alkyl, alkenyl, acyl, alkoxy, alkoxyalkyl, halo or groups containing N, O, P or S and optionally containing ring hetero atoms; aryl, aralkyl, heteroaryl or heteroaralkyl optionally ring-substituted with alkyl, alkenyl, alkynyl, acyl, alkoxy, alkoxyalkyl, halo, CN, CONH2 or groups containing N, O, P or S; or a N-bonded amino acid or peptide group; R2 = H; alkyl, alkenyl, alkynyl or alkoxyalkyl optionally substituted with halo or groups containing N, O, P or S; cycloalkyl optionally unsaturated, optionally substituted with alkyl, alkenyl, acyl, alkoxy, alkoxyalkyl, halo or groups containing N, O, P or S and/or optionally containing ring hetero atoms; aryl, aralkyl, heteroaryl or heteroaralkyl optionally ring-substituted with alkyl, alkenyl, alkynyl, acyl, alkoxy, alkoxyalkyl, halo or groups containing N, O, P or S; R3 = H; acyl; a C-bonded amino acid or peptide group; or a peptide protecting group; and Y = alkylene optionally substituted with alkyl, halo, OH or phenyl; or aralkyl optionally substituted with alkyl, halo or OH. The full definitions are given in the DEFINITIONS (Full Definitions) Field. Independent claims are also included for the following: (1) S-substituted methionine derivatives of formula (II) and their addition salts; and (2) preparation of compounds of formula (II).

公开(公告)号：DE59911425D1

公开(公告)日：2005-02-17

申请号：DE59911425

申请日：1999-06-12

Applicant: DEGUSSA

Inventor： KNOCHEL PAUL PROF ,  ALMENA PEREA JUAN JOSE DR ,  DRAUZ KARLHEINZ PROF ,  KLEMENT INGO DR

IPC: B01J31/22 ,  C07B53/00 ,  C07C51/36 ,  C07C67/303 ,  C07C67/31 ,  C07C227/32

公开(公告)号：DE59910801D1

公开(公告)日：2004-11-18

申请号：DE59910801

申请日：1999-06-12

Applicant: DEGUSSA

Inventor： KNOCHEL PAUL PROF ,  ALMENA PEREA JUAN JOSE DR ,  DRAUZ KARLHEINZ PROF ,  KLEMENT INGO DR

IPC: B01J31/22 ,  C07B53/00