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    CATHETER WITH INTEGRAL BIOSENSOR
    1.
    发明申请
    CATHETER WITH INTEGRAL BIOSENSOR 审中-公开
    带有整体生物传感器的导管

    公开(公告)号：WO2007100796A3

    公开(公告)日：2007-11-01

    申请号：PCT/US2007005020

    申请日：2007-02-26

    Applicant: EDWARDS LIFESCIENCES CORP ,  CARLIN PATRICK ,  HIGGINS MICHAEL J ,  CURRY KENNETH M ,  FJIELD TODD ,  HEITZMANN HAL

    Inventor： CARLIN PATRICK ,  HIGGINS MICHAEL J ,  CURRY KENNETH M ,  FJIELD TODD ,  HEITZMANN HAL

    IPC: A61M25/00 ,  A61B5/00

    CPC classification number: A61B5/14542 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6852 ,  A61M25/003 ,  A61M25/0032 ,  A61M25/007 ,  A61M2025/0034

    Abstract: A single or multilumen intravenous catheter that may include an integral biosensor having an active portion exposed through a sensing port formed in a distal portion of an outer wall of the catheter. The biosensor may be formed on a flex circuit mounted to a support member or probe that displaces the active portion from an inner wall of the catheter for protection from friction during installation through a lumen. The support member or probe may position the biosensor concentrically within the lumen or against an inner diameter of the outer wall. The biosensor may be sealed about the sensing port to prevent passage of fluid therethrough, or a proximal end of the sensing port may remain open to allow flushing of the biosensor with saline infused through the lumen.

    Abstract translation: 单个或多个内腔静脉导管可以包括整体生物传感器，其具有通过形成在导管外壁的远端部分中的感测端口暴露的有源部分。 生物传感器可以形成在柔性电路上，该柔性电路安装到支撑构件或探针上，该支撑构件或探针将活性部分从导管的内壁置换以防止在穿过内腔安装期间发生摩擦。 支撑构件或探针可将生物传感器同心地定位在内腔内或抵靠外壁的内径。 生物传感器可以围绕感测端口密封以防止流体通过其中，或者感测端口的近端可以保持打开以允许用通过内腔注入的盐水冲洗生物传感器。

    METHOD OF PACKAGING AND PACKAGE FOR SENSORS
    2.
    发明申请
    METHOD OF PACKAGING AND PACKAGE FOR SENSORS 审中-公开
    传感器的包装和包装方法

    公开(公告)号：WO2010068587A3

    公开(公告)日：2010-09-16

    申请号：PCT/US2009066968

    申请日：2009-12-07

    Applicant: EDWARDS LIFESCIENCES CORP ,  CURRY KENNETH ,  FJIELD TODD ,  HIGGINS MICHAEL J ,  CARLIN PATRICK ,  CARLIN GREGORY J

    Inventor： CURRY KENNETH ,  FJIELD TODD ,  HIGGINS MICHAEL J ,  CARLIN PATRICK ,  CARLIN GREGORY J

    IPC: A61B5/145 ,  A61B5/1459

    CPC classification number: A61B5/14532 ,  A61B5/14865 ,  A61B2562/242 ,  B65D81/05 ,  B65D81/2061 ,  B65D81/2084

    Abstract: There are provided methods of packaging and packages that prevent damage of the package contents while maintaining sterility and that limit the negative effects of sterilization on sensors such as enzyme sensors. A method of packaging an enzyme sensor includes providing an enzyme sensor such as a glucose oxidase sensor in a gas impermeable package comprising one or more of oxygen and water, removing a significant portion of the oxygen and water present in the package, and sealing the package. The resulting package comprises the enzyme sensor in an atmosphere that is substantially free of oxygen and water. The package can also include a pressure indicator that indicates when the package has exceeded a predetermined pressure.

    Abstract translation: 提供了包装和包装方法，以防止包装内容物受损，同时保持无菌状态，并限制灭菌对诸如酶传感器等传感器的负面影响。 包装酶传感器的方法包括在不透气包装中提供酶传感器如葡萄糖氧化酶传感器，所述不透气包装包含氧气和水中的一种或多种，​​除去包装中存在的大部分氧气和水，并将包装 。 所得到的包装包含在基本上不含氧气和水的气氛中的酶传感器。 包装还可以包括指示包装何时超过预定压力的压力指示器。

    CATHETER WITH INTEGRAL BIOSENSOR
    4.
    发明专利
    CATHETER WITH INTEGRAL BIOSENSOR 未知

    公开(公告)号：CA2630533A1

    公开(公告)日：2007-09-07

    申请号：CA2630533

    申请日：2007-02-26

    Applicant: EDWARDS LIFESCIENCES CORP

    Inventor： HEITZMANN HAROLD A ,  CURRY KENNETH M ,  FJIELD TODD ,  CARLIN PATRICK ,  HIGGINS MICHAEL J

    IPC: A61M25/00 ,  A61B5/00

    Abstract: A single or multilumen intravenous catheter that may include an integral biosensor having an active portion exposed through a sensing port formed in a distal portion of an outer wall of the catheter. The biosensor may be formed on a flex circuit mounted to a support member or probe that displaces the active portion from an inner wall of the catheter for protection from friction during installation through a lumen. The support member or probe may position the biosensor concentrically within the lumen or against an inner diameter of the outer wall. The biosensor may be sealed about the sensing port to prevent passage of fluid therethrough, or a proximal end of the sensing port may remain open to allow flushing of the biosensor with saline infused through the lumen.

    CATHETER AND PROBE FOR MEASURING ANALYTES OR OTHER PARAMETERS
    6.
    发明专利
    CATHETER AND PROBE FOR MEASURING ANALYTES OR OTHER PARAMETERS 未知

    公开(公告)号：CA2695542A1

    公开(公告)日：2009-02-12

    申请号：CA2695542

    申请日：2008-08-08

    Applicant: EDWARDS LIFESCIENCES CORP

    Inventor： FJIELD TODD ,  HIGGINS MICHAEL J

    IPC: A61B5/00

    Abstract: A medical sensing system including an access tube with a fluid infusate lumen and a sensing probe that can be passed through a second lumen in the access tube and extended into the vasculature for sensing a blood parameter. The sensing probe has a sensor on a distal end thereof and a shape that permits it to extend from the access tube such that the sensor is displaced laterally from the access tube, and out of the infusate flow. If the sensing probe passes through the lumen opening at the distal tip of the catheter, the distal end of the probe bends or otherwise deflects laterally so that the sensor is displaced laterally from the infusate flow path. Alternatively, the probe may exit a side port of the access tube upstream of an infusate side port. The deflectable probe is particularly useful for sensing glucose in blood through any number of conventional, off-the-shelf catheters.

    MONITORING AND COMPENSATING FOR TEMPERATURE-RELATED ERROR INAN ELECTROCHEMICAL SENSOR
    9.
    发明专利
    MONITORING AND COMPENSATING FOR TEMPERATURE-RELATED ERROR INAN ELECTROCHEMICAL SENSOR 未知

    公开(公告)号：CA2688425A1

    公开(公告)日：2009-04-30

    申请号：CA2688425

    申请日：2008-10-02

    Applicant: EDWARDS LIFESCIENCES CORP

    Inventor： FJIELD TODD ,  HIGGINS MICHAEL

    IPC: A61B5/00 ,  G01N33/49

    Abstract: A method for compensating for a temperature-related error in an electroch emical sensor without using separate sources of temperature measurement by m easuring sensor current, temporarily lowering sensor voltage to a first leve l below a reaction-sustaining threshold, measuring a first offset current, a djusting sensor voltage to a second level below the threshold, measuring a s econd offset current, calculating a difference between the offset currents, deriving a temperature compensation value from the difference based on empir ical data, and adding the value to the measured sensor current. A computer s ystem may execute the method as an algorithm stored in memory, provide autom atic control of the sensor, and provide continuous display of corrected outp ut values.

    TEMPERATURE COMPENSATION FOR ENZYME ELECTRODES
    10.
    发明专利
    TEMPERATURE COMPENSATION FOR ENZYME ELECTRODES 未知

    公开(公告)号：CA2667243A1

    公开(公告)日：2008-06-26

    申请号：CA2667243

    申请日：2007-11-16

    Applicant: EDWARDS LIFESCIENCES CORP

    Inventor： HIGGINS MICHAEL J ,  FJIELD TODD ,  CARLIN PATRICK ,  CURRY KENNETH

    IPC: A61B5/1486

    Abstract: A temperature compensation method for an enzyme electrode by measuring an operating temperature of the enzyme electrode, measuring the current genera ted by the enzyme electrode, determining a deviation in measurement between the current generated and a reference current at the operating temperature, determining an enzyme concentration corresponding to the measured current, a nd calibrating the enzyme concentration to compensate for the deviation in m easurement.

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