公开(公告)号：JP2006051406A

公开(公告)日：2006-02-23

申请号：JP2005318887

申请日：2005-11-01

Applicant: Edwards Lifesciences Corp ,  エドワーズ ライフサイエンシーズ コーポレイションEdwards Lifesciences Corporation

Inventor： MOONEY CHARLES ,  PECOR ROBERT ,  BOBO DONALD E JR ,  HIGGINS MICHAEL J

IPC: A61B17/00 ,  A61M25/00 ,  A61B17/34 ,  A61M25/06 ,  A61M39/00

CPC classification number: A61B17/3417 ,  A61B17/3498 ,  A61B2017/3445 ,  A61B2017/3466 ,  A61M25/0023 ,  A61M25/0032 ,  A61M25/0075 ,  A61M25/0668 ,  A61M2025/0034 ,  A61M2025/0035 ,  A61M2025/0036

Abstract: PROBLEM TO BE SOLVED: To provide a system to simplify a production process and to enable various medical appliances to be attached. SOLUTION: A multi-lumen access system which is used when an introduction port into a human body is set to selectively introduce a medical device through it and to provide a simultaneous auxiliary access into the body is equipped with a device lumen, an auxiliary lumen, a device lumen valve which sets the sealing of the device lumen in both the cases of the presence and the absence of the medical device in the medical device lumen, and an attachment housing which is made of a soft and flexible material, wherein the attachment housing includes a main channel and an auxiliary channel and the main channel and the auxiliary channel branch off from an outside tube not to intersect each other in the attachment housing, and here, a valve insertion section equipped with the device lumen valve is formed to be separated from the attachment housing and has a structure to facilitate the connection of the medical device to the valve insertion section. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种简化生产过程并且能够附接各种医疗器具的系统。 解决方案：当将引入人体的引入口设置成选择性地通过其引入医疗装置并且向身体提供同时辅助进入时使用的多管腔存取系统配备有装置内腔， 辅助内腔，在医疗装置内腔中存在和不存在医疗装置的情况下设定装置内腔的密封的装置内腔阀以及由柔软且柔软的材料制成的附接壳体，其中 附件壳体包括主通道和辅助通道，并且主通道和辅助通道从外管分支，在附接壳体中彼此不相交，并且这里形成配备有器件管腔阀的阀插入部分 与附接壳体分离并且具有便于医疗装置与阀插入部分连接的结构。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2007152137A

公开(公告)日：2007-06-21

申请号：JP2007031339

申请日：2007-02-09

Applicant: Edwards Lifesciences Corp ,  エドワーズ ライフサイエンシーズ コーポレイションEdwards Lifesciences Corporation

Inventor： MOONEY CHARLES ,  PECOR ROBERT ,  BOBO DONALD E JR ,  HIGGINS MICHAEL J

IPC: A61B17/00 ,  A61M25/00 ,  A61B17/34 ,  A61M25/06 ,  A61M39/00

CPC classification number: A61B17/3417 ,  A61B17/3498 ,  A61B2017/3445 ,  A61B2017/3466 ,  A61M25/0023 ,  A61M25/0032 ,  A61M25/0075 ,  A61M25/0668 ,  A61M2025/0034 ,  A61M2025/0035 ,  A61M2025/0036

Abstract: PROBLEM TO BE SOLVED: To provide a system, having a simplified manufacturing process and mounted with various medical implements. SOLUTION: A multiple lumen access system for use in providing a single entry port into the human body for selectively introducing medical implements therethrough and for providing simultaneous auxiliary access into the body. The multiple lumen access system includes: a device lumen; an auxiliary lumen; a device lumen valve which provides sealing of the device lumen in both of the case where the medical implement exists in the device lumen and the case where it is absent there; and a junction housing made of flexible material. The junction housing includes a main channel and an auxiliary channel, and the main channel and the auxiliary channel branch from an outer tube not to intersect in the junction housing. In this case, a valve insert part provided with the device lumen valve is formed separate from the junction housing, thereby providing a structure to promote the connection to the device. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：提供一种具有简化的制造过程并且安装有各种医疗器具的系统。 解决方案：一种用于向人体提供单个入口的多腔腔存取系统，用于选择性地引入医疗器械，并提供同时辅助的进入体内。 多腔腔存取系统包括：装置内腔; 辅助管腔 在设备内腔中存在医疗器具的情况和其中不存在的情况下，在设备内腔中提供密封的装置管腔阀; 以及由柔性材料制成的接头壳体。 接头壳体包括主通道和辅助通道，并且主通道和辅助通道从外管分支而不在接合壳体中相交。 在这种情况下，设置有装置管腔阀的阀插入部分与接合壳体分开形成，从而提供促进与装置的连接的结构。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：WO2010068587A3

公开(公告)日：2010-09-16

申请号：PCT/US2009066968

申请日：2009-12-07

Applicant: EDWARDS LIFESCIENCES CORP ,  CURRY KENNETH ,  FJIELD TODD ,  HIGGINS MICHAEL J ,  CARLIN PATRICK ,  CARLIN GREGORY J

Inventor： CURRY KENNETH ,  FJIELD TODD ,  HIGGINS MICHAEL J ,  CARLIN PATRICK ,  CARLIN GREGORY J

IPC: A61B5/145 ,  A61B5/1459

CPC classification number: A61B5/14532 ,  A61B5/14865 ,  A61B2562/242 ,  B65D81/05 ,  B65D81/2061 ,  B65D81/2084

Abstract: There are provided methods of packaging and packages that prevent damage of the package contents while maintaining sterility and that limit the negative effects of sterilization on sensors such as enzyme sensors. A method of packaging an enzyme sensor includes providing an enzyme sensor such as a glucose oxidase sensor in a gas impermeable package comprising one or more of oxygen and water, removing a significant portion of the oxygen and water present in the package, and sealing the package. The resulting package comprises the enzyme sensor in an atmosphere that is substantially free of oxygen and water. The package can also include a pressure indicator that indicates when the package has exceeded a predetermined pressure.

Abstract translation: 提供了包装和包装方法，以防止包装内容物受损，同时保持无菌状态，并限制灭菌对诸如酶传感器等传感器的负面影响。 包装酶传感器的方法包括在不透气包装中提供酶传感器如葡萄糖氧化酶传感器，所述不透气包装包含氧气和水中的一种或多种，​​除去包装中存在的大部分氧气和水，并将包装 。 所得到的包装包含在基本上不含氧气和水的气氛中的酶传感器。 包装还可以包括指示包装何时超过预定压力的压力指示器。

公开(公告)号：WO2011003000A2

公开(公告)日：2011-01-06

申请号：PCT/US2010040793

申请日：2010-07-01

Applicant: EDWARDS LIFESCIENCES CORP ,  PETISCE JAMES ,  HIGGINS MICHAEL J ,  TRINH KRISTIE ,  ABRAHAM TODD

Inventor： PETISCE JAMES ,  HIGGINS MICHAEL J ,  TRINH KRISTIE ,  ABRAHAM TODD

IPC: A61J1/05 ,  A61J1/20 ,  A61J1/22 ,  A61M5/14 ,  A61M5/168

CPC classification number: G01N33/96 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/4839 ,  A61M2207/00 ,  A61M2230/201 ,  Y10T436/10 ,  Y10T436/102499 ,  Y10T436/104998 ,  Y10T436/108331

Abstract: Methods and systems for preparation of calibrant infusion fluid sources are disclosed. In one embodiment, a precise volume of glucose is injected into a saline-solution filled calibrant infusion fluid source proximate in time to conducting a calibration procedure. The glucose concentration in the calibrant infusion fluid source is subsequently calculated based on the measured weight of the saline-solution, as determined prior to glucose injection, and the volume of glucose injected. This method provides a highly accurate and convenient manner for use in a hospital environment, for example, with an intravenous blood glucose sensor system. In another embodiment, a premixed calibrant infusion fluid source is provided that includes saline solution and a predetermined concentration of glucose. In such embodiments, shelf life problems related to water evaporation are mitigated by hermetically covering or otherwise hermetically containing the calibrant infusion fluid source up until the point of use.

Abstract translation: 公开了用于制备校准物输注流体源的方法和系统。 在一个实施方案中，精确体积的葡萄糖在进行校准程序的时间附近被注入充满盐水的校准剂输液流体源中。 随后基于测量的葡萄糖注射前测定的盐水溶液的重量和注射的葡萄糖的体积计算校准物输注流体源中的葡萄糖浓度。 该方法提供了用于医院环境中的高度准确和方便的方式，例如，利用静脉内血糖传感器系统。 在另一个实施方案中，提供预混合的校准剂输液流体源，其包含盐水溶液和预定浓度的葡萄糖。 在这样的实施方案中，与水蒸发有关的保质期问题通过气密地覆盖或以其他方式气密地容纳校准剂输注流体源直到使用点而减轻。

公开(公告)号：WO2007100796A3

公开(公告)日：2007-11-01

申请号：PCT/US2007005020

申请日：2007-02-26

Applicant: EDWARDS LIFESCIENCES CORP ,  CARLIN PATRICK ,  HIGGINS MICHAEL J ,  CURRY KENNETH M ,  FJIELD TODD ,  HEITZMANN HAL

Inventor： CARLIN PATRICK ,  HIGGINS MICHAEL J ,  CURRY KENNETH M ,  FJIELD TODD ,  HEITZMANN HAL

IPC: A61M25/00 ,  A61B5/00

CPC classification number: A61B5/14542 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6852 ,  A61M25/003 ,  A61M25/0032 ,  A61M25/007 ,  A61M2025/0034

Abstract: A single or multilumen intravenous catheter that may include an integral biosensor having an active portion exposed through a sensing port formed in a distal portion of an outer wall of the catheter. The biosensor may be formed on a flex circuit mounted to a support member or probe that displaces the active portion from an inner wall of the catheter for protection from friction during installation through a lumen. The support member or probe may position the biosensor concentrically within the lumen or against an inner diameter of the outer wall. The biosensor may be sealed about the sensing port to prevent passage of fluid therethrough, or a proximal end of the sensing port may remain open to allow flushing of the biosensor with saline infused through the lumen.

Abstract translation: 单个或多个内腔静脉导管可以包括整体生物传感器，其具有通过形成在导管外壁的远端部分中的感测端口暴露的有源部分。 生物传感器可以形成在柔性电路上，该柔性电路安装到支撑构件或探针上，该支撑构件或探针将活性部分从导管的内壁置换以防止在穿过内腔安装期间发生摩擦。 支撑构件或探针可将生物传感器同心地定位在内腔内或抵靠外壁的内径。 生物传感器可以围绕感测端口密封以防止流体通过其中，或者感测端口的近端可以保持打开以允许用通过内腔注入的盐水冲洗生物传感器。

公开(公告)号：WO2011106318A2

公开(公告)日：2011-09-01

申请号：PCT/US2011025738

申请日：2011-02-22

Applicant: EDWARDS LIFESCIENCES CORP ,  PHAN LUONG NGOC ,  BACKER STEVEN ,  WILBUR JENNIFER ,  HIGGINS MICHAEL J

Inventor： PHAN LUONG NGOC ,  BACKER STEVEN ,  WILBUR JENNIFER ,  HIGGINS MICHAEL J

IPC: A61B5/145 ,  G06F17/40

CPC classification number: A61B5/002 ,  A61B5/022 ,  A61B2560/045 ,  A61B2562/08

Abstract: A system for sensing a physiological parameter in a human or animal, and storing a processed sensing signal at a sensor with which the sensing was performed. The system includes a physiological sensor adapted to output a sensor signal representative of a sensed physiological parameter, for processing by a remote processor. A microcontroller has memory, and is located locally to the sensor and is fixedly attached to or housed together with the sensor. An authentication algorithm is stored in the memory and the microprocessor is configured to engage in an authentication process to authenticate the sensor when queried by a remote processor. The memory is configured to receive and store data representative of a sensed physiological parameter after data from the sensor has been processed by a remote processor. The microcontroller may be configured to communicate with a remote processor over a single wire by, for example, using a single wire protocol.

Abstract translation: 一种用于感测人或动物中的生理参数并将经处理的感测信号存储在执行感测的传感器的系统。 该系统包括适于输出表示感测的生理参数的传感器信号的生理传感器，用于由远程处理器进行处理。 微控制器具有存储器，并且位于传感器的本地并且固定地附接到传感器或与传感器一起容纳。 认证算法存储在存储器中，并且微处理器被配置为参与认证过程以在远程处理器查询时认证传感器。 存储器被配置为在远程处理器处理来自传感器的数据之后接收和存储表示感测到的生理参数的数据。 微控制器可以被配置为通过例如使用单线协议通过单个线路与远程处理器进行通信。

公开(公告)号：WO2008076574A2

公开(公告)日：2008-06-26

申请号：PCT/US2007084993

申请日：2007-11-16

Applicant: EDWARDS LIFESCIENCES CORP ,  FJIELD TODD ,  HIGGINS MICHAEL J ,  CURRY KENNETH ,  CARLIN PATRICK

Inventor： FJIELD TODD ,  HIGGINS MICHAEL J ,  CURRY KENNETH ,  CARLIN PATRICK

IPC: G01N33/50

CPC classification number: C12Q1/006 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/1495 ,  A61B2560/0252

Abstract: A temperature compensation method for an enzyme electrode by measuring an operating temperature of the enzyme electrode, measuring the current generated by the enzyme electrode, determining a deviation in measurement between the current generated and a reference current at the operating temperature, determining an enzyme concentration corresponding to the measured current, and calibrating the enzyme concentration to compensate for the deviation in measurement.

Abstract translation: 一种酶电极的温度补偿方法，通过测量酶电极的操作温度，测量由酶电极产生的电流，确定所产生的电流和参考电流之间的测量偏差在操作温度下，确定相应的酶浓度 到测量电流，并校准酶浓度以补偿测量的偏差。

公开(公告)号：WO2007033318A2

公开(公告)日：2007-03-22

申请号：PCT/US2006035830

申请日：2006-09-13

Applicant: EDWARDS LIFESCIENCES CORP ,  HIGGINS MICHAEL J

Inventor： HIGGINS MICHAEL J

IPC: A61B5/00 ,  G01N33/49

CPC classification number: A61B5/14535 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/417 ,  A61B5/7203 ,  G01N33/49

Abstract: Methods for measuring the total hemoglobin of whole blood include measuring reflective light at multiple wavelengths within the visible spectrum, calculating light absorbance at each of the multiple wavelengths, performing a comparison in a change in like absorbance between the multiple wavelengths, and/or relating the comparison to total hemoglobin. A system for measuring total hemoglobin of whole blood may include at least one light source, a catheter, optical fibers, at least one photodetector, data processing circuitry, and/or a display unit.

Abstract translation: 用于测量全血的总血红蛋白的方法包括测量可见光谱内的多个波长的反射光，计算多个波长中的每个波长处的光吸收，在多个波长之间的类似吸光度的变化中进行比较和/或将 与总血红蛋白比较。 用于测量全血的总血红蛋白的系统可以包括至少一个光源，导管，光纤，至少一个光电检测器，数据处理电路和/或显示单元。

公开(公告)号：WO0074760A2

公开(公告)日：2000-12-14

申请号：PCT/US0015802

申请日：2000-06-08

Applicant: EDWARDS LIFESCIENCES CORP

Inventor： MOONEY CHARLES R ,  PECOR ROBERT ,  BOBO DONALD E JR ,  HIGGINS MICHAEL J ,  MIRAKI MANOUCHEHR A ,  BULMAN ERIK E ,  WILLOUGHBY GARY R

IPC: A61B17/34 ,  A61M25/00 ,  A61M25/14 ,  A61M25/18

CPC classification number: A61M25/0097 ,  A61B17/3439 ,  A61B2017/3445 ,  A61M25/0023 ,  A61M25/0032 ,  A61M2025/0034 ,  A61M2025/0035 ,  A61M2025/0036

Abstract: A multiple lumen access device for use in providing a single entry port into the human body for selectively introducing medical implements therethrough and for providing simultaneous auxiliary access into the body. The multiple lumen access device includes a multi-lumen sheath which may have an outer tube and structure defining a device lumen located therein. The inner structure may be an inner wall or inner tube. The outer tube and inner structure are located so as to define at least one auxiliary lumen. Some embodiments include flexible inner walls which can be flexed between relaxed and expanded/contracted positions wherein the relative cross-sectional areas of the device lumen and auxiliary lumens are varied. The access device further includes a valve which provides sealing of the device lumen. The valve may be provided in a lumen junction housing or separate from the housing either permanently or removably connected with the device lumen. Alternatively, a multi-lumen sheath may be passed through a valve leading to a conventional introducer. The valve may also be molded separately as a rigid insert and retained in a cavity formed in a flexible junction housing. In other embodiments, the multiple lumen access device is formed by introduction of the elongated implement coaxially within a tubular single lumen sheath.

Abstract translation: 一种用于向人体提供单个入口的多流体存取装置，用于选择性地引入医疗器具，并提供同时辅助的进入身体。 多管腔进入装置包括多腔护套，其可以具有限定位于其中的装置内腔的外管和结构。 内部结构可以是内壁或内管。 外管和内部结构被定位成限定至少一个辅助腔。 一些实施例包括柔性内壁，其可以在松弛和膨胀/收缩位置之间弯曲，其中装置内腔和辅助流明的相对横截面面积是变化的。 进入装置还包括提供装置内腔的密封的阀。 阀可以设置在管腔接合壳体中或与壳体分离地永久地或可移除地与装置内腔连接。 或者，多腔护套可以通过通向常规导引器的阀。 阀也可以单独模制成刚性插入件并且保持在形成在柔性连接件壳体中的空腔中。 在其他实施例中，通过将细长工具同轴地引导到管状单腔护套内而形成多腔入口装置。

公开(公告)号：EP2538843A4

公开(公告)日：2013-07-24

申请号：EP11747930

申请日：2011-02-22

Applicant: EDWARDS LIFESCIENCES CORP

Inventor： PHAN LUONG NGOC ,  BACKER STEVEN ,  WILBUR JENNIFER ,  HIGGINS MICHAEL J

IPC: G06F17/40 ,  A61B5/00

CPC classification number: A61B5/002 ,  A61B5/022 ,  A61B2560/045 ,  A61B2562/08

Abstract: A system for sensing a physiological parameter in a human or animal, and storing a processed sensing signal at a sensor with which the sensing was performed. The system includes a physiological sensor adapted to output a sensor signal representative of a sensed physiological parameter, for processing by a remote processor. A microcontroller has memory, and is located locally to the sensor and is fixedly attached to or housed together with the sensor. An authentication algorithm is stored in the memory and the microprocessor is configured to engage in an authentication process to authenticate the sensor when queried by a remote processor. The memory is configured to receive and store data representative of a sensed physiological parameter after data from the sensor has been processed by a remote processor. The microcontroller may be configured to communicate with a remote processor over a single wire by, for example, using a single wire protocol.

Abstract translation: 一种用于感测人或动物中的生理参数并将经处理的感测信号存储在执行感测的传感器的系统。 该系统包括适于输出表示感测的生理参数的传感器信号以供远程处理器处理的生理传感器。 微控制器具有存储器，并且位于传感器的本地，并且固定地连接到传感器或与传感器一起容纳。 认证算法被存储在存储器中，并且微处理器被配置为在由远程处理器查询时参与认证过程以认证传感器。 存储器被配置为在来自传感器的数据已经被远程处理器处理之后接收并存储表示感测到的生理参数的数据。 微控制器可以被配置为通过例如使用单线协议通过单线与远程处理器通信。