公开(公告)号：WO2018209020A1

公开(公告)日：2018-11-15

申请号：PCT/US2018/031958

申请日：2018-05-10

Applicant: EMD MILLIPORE CORPORATION

Inventor： CLARK, Phillip ,  GREENIZEN, Kurt E. ,  DOYLE, John

IPC: B01D29/00

Abstract: Filtration apparatus for the assay of biological and biochemical reactants, for example, is provided and includes a substrate such as a plate having one or more wells open at each end, and a porous membrane positioned in each well forming a discrete filtering area. The filtration apparatus includes a seal that is in a compressible relationship with the face of the porous membrane, the surface of the compression element, and the well wall. Each well includes a compression element, such as an internal well insert or sleeve, which compresses the seal so that the seal contacts the membrane face, the surface of the compression element, and the well wall in a liquid-tight manner. The compression element may be configured so that it is fixed in the well such as by an interference fit with the well wall or by bonding to a surface of the substrate.

公开(公告)号：WO2017192269A1

公开(公告)日：2017-11-09

申请号：PCT/US2017/028485

申请日：2017-04-20

Applicant: EMD MILLIPORE CORPORATION

Inventor： GREENIZEN, Kurt E. ,  SCOTT, Christopher A. ,  SYDLOWSKI, Paul ,  DOYLE, John ,  AMARA, Ryan A.

IPC: B25B7/14 ,  B25B7/02 ,  B25B7/12 ,  B25B1/04 ,  B25B3/00 ,  B25B5/04 ,  B25B5/08 ,  B25B5/12

Abstract: A clamp including a first jaw member having a camming surface, a second jaw member pivotable with respect to the first jaw member, a first biasing member biasing the first and second jaw members to a first position; and a locking mechanism that includes a cam or roller for cooperating with the camming surface of the jaw member, and a second biasing member biasing the cam or roller against the camming surface to lock the first and second jaw members in a second position. An optional alignment collar can be used to align components of the filtration apparatus prior to clamping. Filtration apparatus including the clamp, and also optionally including the alignment collar, is also disclosed.

Abstract translation: 包括具有凸轮表面的第一钳口构件，可相对于第一钳口构件枢转的第二钳口构件，将第一钳口构件和第二钳口构件偏压到第一位置的第一偏置构件; 以及锁定机构，该锁定机构包括用于与钳口构件的凸轮表面配合的凸轮或辊子，以及第二偏压构件，其将凸轮或辊子偏压抵靠凸轮表面以将第一钳口构件和第二钳口构件锁定在第二位置。 在夹紧之前，可以使用可选的对齐套环来对准过滤装置的部件。 还公开了包括夹具的过滤设备，并且还可选地包括对齐套环。

公开(公告)号：WO2012154905A1

公开(公告)日：2012-11-15

申请号：PCT/US2012/037211

申请日：2012-05-10

Applicant: EMD MILLIPORE CORPORATION ,  SCOTT, Chris ,  CLARK, Phillip ,  GREENIZEN, Kurt E. ,  AMARA, Ryan A. ,  COLONNA, Robert

Inventor： SCOTT, Chris ,  CLARK, Phillip ,  GREENIZEN, Kurt E. ,  AMARA, Ryan A. ,  COLONNA, Robert

IPC: G01N31/22

CPC classification number: G01N33/558 ,  B01J20/28033 ,  B01J20/28035 ,  B01J20/2804 ,  B01L3/5023 ,  B01L9/52 ,  B01L2200/025 ,  B01L2300/0609 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2300/0809 ,  B01L2300/12 ,  B01L2300/126 ,  B01L2400/0487 ,  B01L2400/049 ,  G01N33/54366 ,  G01N33/56911 ,  G01N2469/10 ,  G01N2469/20

Abstract: The embodiments disclosed herein are directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so.

Abstract translation: 本文公开的实施方案涉及用于在印迹膜上进行化合物检测的装置。 该装置包括多个层，包括印迹膜下面的多孔支撑层，印迹膜上方的流量分布器，以及任选的流量分配器上的孔，以将液体包含到期望的区域并允许 降低这种液体的起始体积。 优选地，流动分配器是非结合或低结合的亲水性多孔膜，例如0.22微米的膜，并且支撑层是格栅或烧结的多孔材料。 分配器和支撑件保持在一起以在膜周围形成一个信封。 在这样做时优选使用铰链，夹子和其它这样的装置。

公开(公告)号：EP3621716A1

公开(公告)日：2020-03-18

申请号：EP18798068.5

申请日：2018-05-10

Applicant: EMD Millipore Corporation

Inventor： CLARK, Phillip ,  GREENIZEN, Kurt E. ,  DOYLE, John

IPC: B01D29/00

公开(公告)号：EP4508425A1

公开(公告)日：2025-02-19

申请号：EP23728229.8

申请日：2023-05-01

Applicant: EMD Millipore Corporation

Inventor： GREENIZEN, Kurt E. ,  BAILEY, Trisha ,  AMARA, Ryan ,  LIBBY, Gerard ,  SYDLOWSKI, Paul ,  JIMENEZ, Mayra

IPC: G01N27/447

公开(公告)号：EP3452254A1

公开(公告)日：2019-03-13

申请号：EP17793000.5

申请日：2017-04-20

Applicant: EMD Millipore Corporation

Inventor： GREENIZEN, Kurt E. ,  SCOTT, Christopher A. ,  SYDLOWSKI, Paul ,  DOYLE, John ,  AMARA, Ryan A.

IPC: B25B7/14 ,  B25B7/02 ,  B25B7/12 ,  B25B1/04 ,  B25B3/00 ,  B25B5/04 ,  B25B5/08 ,  B25B5/12

公开(公告)号：EP2707708A1

公开(公告)日：2014-03-19

申请号：EP12781832.6

申请日：2012-05-10

Applicant: EMD Millipore Corporation

Inventor： SCOTT, Chris ,  CLARK, Phillip ,  GREENIZEN, Kurt E. ,  AMARA, Ryan A. ,  COLONNA, Robert

IPC: G01N31/22

CPC classification number: G01N33/558 ,  B01J20/28033 ,  B01J20/28035 ,  B01J20/2804 ,  B01L3/5023 ,  B01L9/52 ,  B01L2200/025 ,  B01L2300/0609 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2300/0809 ,  B01L2300/12 ,  B01L2300/126 ,  B01L2400/0487 ,  B01L2400/049 ,  G01N33/54366 ,  G01N33/56911 ,  G01N2469/10 ,  G01N2469/20

Abstract: The embodiments disclosed herein are directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so.