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    GEL CAST CASSETTE AND HAND CAST SYSTEM
    1.
    发明申请
    GEL CAST CASSETTE AND HAND CAST SYSTEM 审中-公开

    公开(公告)号：WO2020146565A1

    公开(公告)日：2020-07-16

    申请号：PCT/US2020/012829

    申请日：2020-01-09

    Applicant: EMD MILLIPORE CORPORATION

    Inventor： GREENIZEN, Kurt ,  SCOTT, Christopher ,  SYDLOWSKI, Paul ,  WU, Kevin ,  AMARA, Ryan ,  MANNING, Ryan ,  GUTIERREZ, Sara ,  DOYLE, John

    IPC: G01N27/447

    Abstract: The embodiments disclosed herein are directed to a device and assembly useful for hand casting an electrophoretic separation medium. The device includes a cassette frame 10 comprising first and second arms or members 12,22 pivotally connected to one another. One or more hinges 35A,35B may be provided to allow the first member to swing or pivot relative to the second member 12,22 (or vice versa) between a cassette frame open position and a cassette frame closed position. The first and second members 12,22 each include a substrate 20,30 to maintain a gel interface, preferably a glass plate substrate. The assembly includes a base and clamping arms that cooperate to hold one or more cassette frames in compressed relation.

    SYSTEM AND METHOD FOR PHOTOPOLYMERIZING ELECTROPHORETIC GELS
    2.
    发明申请
    SYSTEM AND METHOD FOR PHOTOPOLYMERIZING ELECTROPHORETIC GELS 审中-公开

    公开(公告)号：WO2023027978A1

    公开(公告)日：2023-03-02

    申请号：PCT/US2022/041012

    申请日：2022-08-22

    Applicant: EMD MILLIPORE CORPORATION

    Inventor： WU, Kevin ,  WOLFE, Kelly ,  DEDEO, Anja ,  AMARA, Ryan ,  LIBBY, Gerard ,  SYDLOWSKI, Paul ,  KAVANAUGH, Katelyn ,  BAILEY, Trisha ,  ALLEN, Nathan T.

    IPC: G01N27/447 ,  G01N27/26

    Abstract: An acrylamide gel formulation for use in electrophoresis, and a system and method for electrophoretic gel casting. In some embodiments, the system comprises a UV-Vis curing light source, and an acrylamide formulation that allows a resolving gel and a stacking gel to be photopolymerized in a single step. In some embodiments, the resolving solution formulation comprises acrylamide and bis-acrylamide, Bis-Tris buffering agent, and lithium phenyl-2, 4, 6-trimethylbenzoyl-phosphinate (LAP) as a water-soluble photoinitiator, which allows the solution to be photopolymerized using UV radiation within a certain wavelength. In some embodiments, a dilution buffer formulation comprises acrylamide and bis-acrylamide, Bis-Tris buffering agent, and lithium phenyl-2, 4, 6-trimethylbenzoyl-phosphinate (LAP). The dilution buffer may be added to the resolving solution in a selected amount in order to modify the concentration of the acrylamide to a desired concentration.

    DEVICE SUITABLE FOR VACUUM ASSISTED FILTRATION
    3.
    发明申请
    DEVICE SUITABLE FOR VACUUM ASSISTED FILTRATION 审中-公开
    适用于真空辅助过滤的装置

    公开(公告)号：WO2018075250A1

    公开(公告)日：2018-04-26

    申请号：PCT/US2017/055219

    申请日：2017-10-05

    Applicant: EMD MILLIPORE CORPORATION

    Inventor： SCOTT, Christopher A. ,  GREENIZEN, Kurt ,  SYDLOWSKI, Paul

    IPC: B01D63/08 ,  B01D61/18 ,  B01L3/00 ,  B01D29/05 ,  B01D61/20

    Abstract: A funnel-less filtration device that attaches directly to a storage container such as a cell culture media bottle. The device includes a filter collar containing one or more membranes, an inlet with a coupling device for attaching the filter device to a supply of liquid to be filtered, an outlet at a lower portion of the collar, a vacuum port in the collar below the membrane(s) and a filtered vent in the collar above the membrane(s). Optionally, the device may include a filtrate reservoir attached to the outlet, preferably by a threaded connection. Optionally, the upper opening to the filter collar is selectively and removably sealed with a lid until used. The lid is then removed the filter device inverted over a storage container such as cell culture media bottle and the two are attached via the upper opening of the filter collar. The assembly is then inverted so the supply container is above the filter device. Upon subjecting the sample in the bottle to a driving force such as vacuum, the sample flows through the filtration element, and into a filtrate reservoir below the outlet of the filter collar.

    Abstract translation: 无漏斗的过滤装置，其直接连接到诸如细胞培养基瓶的储存容器。 该装置包括含有一个或多个膜的过滤器套环，具有用于将过滤装置连接到待过滤的液体供应源的连接装置的入口，在套环下部的出口，在套环下方的套环中的真空口 一个或多个膜和一个或多个膜上方的过滤孔。 任选地，该装置可以包括优选通过螺纹连接连接到出口的滤液贮存器。 可选地，过滤器套环的上部开口用盖子选择性地和可移除地密封直到使用。 然后将盖子倒过滤器装置倒置在诸如细胞培养基瓶的储存容器上，并且两者通过过滤器套环的上开口连接。 然后将组件倒置，使供应容器在过滤装置上方。 在瓶子中的样品受到诸如真空的驱动力之后，样品流过过滤元件并进入过滤器套管出口下方的滤液储液器。

    FILTRATION CLAMP WITH OPTIONAL ALIGNMENT COLLAR AND FILTRATION SYSTEM
    4.
    发明申请
    FILTRATION CLAMP WITH OPTIONAL ALIGNMENT COLLAR AND FILTRATION SYSTEM 审中-公开
    过滤夹具有可选择的校准曲线和过滤系统

    公开(公告)号：WO2017192269A1

    公开(公告)日：2017-11-09

    申请号：PCT/US2017/028485

    申请日：2017-04-20

    Applicant: EMD MILLIPORE CORPORATION

    Inventor： GREENIZEN, Kurt E. ,  SCOTT, Christopher A. ,  SYDLOWSKI, Paul ,  DOYLE, John ,  AMARA, Ryan A.

    IPC: B25B7/14 ,  B25B7/02 ,  B25B7/12 ,  B25B1/04 ,  B25B3/00 ,  B25B5/04 ,  B25B5/08 ,  B25B5/12

    Abstract: A clamp including a first jaw member having a camming surface, a second jaw member pivotable with respect to the first jaw member, a first biasing member biasing the first and second jaw members to a first position; and a locking mechanism that includes a cam or roller for cooperating with the camming surface of the jaw member, and a second biasing member biasing the cam or roller against the camming surface to lock the first and second jaw members in a second position. An optional alignment collar can be used to align components of the filtration apparatus prior to clamping. Filtration apparatus including the clamp, and also optionally including the alignment collar, is also disclosed.

    Abstract translation: 包括具有凸轮表面的第一钳口构件，可相对于第一钳口构件枢转的第二钳口构件，将第一钳口构件和第二钳口构件偏压到第一位置的第一偏置构件; 以及锁定机构，该锁定机构包括用于与钳口构件的凸轮表面配合的凸轮或辊子，以及第二偏压构件，其将凸轮或辊子偏压抵靠凸轮表面以将第一钳口构件和第二钳口构件锁定在第二位置。 在夹紧之前，可以使用可选的对齐套环来对准过滤装置的部件。 还公开了包括夹具的过滤设备，并且还可选地包括对齐套环。

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