公开(公告)号：WO2013022989A2

公开(公告)日：2013-02-14

申请号：PCT/US2012050021

申请日：2012-08-08

Applicant: EVOLVA SA ,  HOUGHTON-LARSEN JENS ,  HICKS PAULA M ,  NAESBY MICHAEL ,  OSTERGAARD TANGE THOMAS ,  HANSEN JORGEN ,  DALGAARD MIKKELSEN MICHAEL ,  HALKJAER HANSEN ESBEN ,  SIMON ERNESTO

Inventor： HOUGHTON-LARSEN JENS ,  HICKS PAULA M ,  NAESBY MICHAEL ,  OSTERGAARD TANGE THOMAS ,  HANSEN JORGEN ,  DALGAARD MIKKELSEN MICHAEL ,  HALKJAER HANSEN ESBEN ,  SIMON ERNESTO

IPC: C12N15/82

CPC classification number: C12P19/56 ,  C12N9/0032 ,  C12N9/0071 ,  C12N9/0073 ,  C12N9/1051 ,  C12N9/1085 ,  C12N9/88 ,  C12N9/90 ,  C12N15/63 ,  C12N15/81 ,  C12N15/8243 ,  C12P19/44 ,  Y02P20/52

Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.

Abstract translation: 公开了已经被工程化以表达编码UDP-糖基转移酶（UGT）的重组基因的重组微生物，植物和植物细胞。 这样的微生物，植物或植物细胞可以产生甜菊糖苷，例如雷鲍迪苷A和/或雷鲍迪苷D，其可以用作食品和膳食补充剂中的天然甜味剂。

公开(公告)号：WO2014030096A3

公开(公告)日：2014-04-17

申请号：PCT/IB2013056604

申请日：2013-08-13

Applicant: BASF SE ,  EVOLVA SA ,  BASF CHINA CO LTD

Inventor： NAESBY MICHAEL ,  FOLLY CHRISTOPHE ,  NIELSEN CURT AIMÉ FRIIS ,  HATSCH ANAELLE ,  SCHWAB MARKUS ,  ZELDER OSKAR ,  HAEFNER STEFAN ,  SCHRÖDER HARTWIG ,  HOFF BIRGIT ,  MOLT ANDREA ,  DITRICH KLAUS ,  BREUER MICHAEL ,  HARTMANN HOLGER ,  KÖRBER KARSTEN

IPC: C12N1/21 ,  A61K31/48 ,  C07K14/195 ,  C07K14/37 ,  C07K16/00 ,  C12N1/15 ,  C12N1/16 ,  C12N15/31 ,  C12N15/52 ,  C12N15/80 ,  C12N15/81 ,  C12P1/00 ,  C12P17/10

CPC classification number: C12P17/12 ,  C07D209/90 ,  C07D487/06 ,  C07K16/40 ,  C12N9/0004 ,  C12N9/001 ,  C12N9/1007 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12P17/182 ,  C12Y205/01

Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

Abstract translation: 用于重组生产角鲨毒碱生物碱如环圈子，festuclavine，agroclavine，chanoclavine和chanoclavine醛的微生物和方法，以及多肽，多核苷酸和包含这样的多核苷酸的载体，其可以用于制造棒状的方法 提供生物碱。

公开(公告)号：EP2888351A4

公开(公告)日：2016-04-27

申请号：EP13831449

申请日：2013-08-13

Applicant: BASF SE ,  EVOLVA SA

Inventor： NAESBY MICHAEL ,  FOLLY CHRISTOPHE ,  NIELSEN CURT AIMÉ FRIIS ,  HATSCH ANAELLE ,  SCHWAB MARKUS ,  ZELDER OSKAR ,  HAEFNER STEFAN ,  SCHRÖDER HARTWIG ,  HOFF BIRGIT ,  MOLT ANDREA ,  DITRICH KLAUS ,  BREUER MICHAEL ,  HARTMANN HOLGER ,  KÖRBER KARSTEN

IPC: C12N15/52 ,  C12N9/00 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90 ,  C12P17/18

CPC classification number: C12P17/12 ,  C07D209/90 ,  C07D487/06 ,  C07K16/40 ,  C12N9/0004 ,  C12N9/001 ,  C12N9/1007 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/52 ,  C12P17/10 ,  C12P17/182 ,  C12Y205/01

Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

Abstract translation: 用于重组生产角鲨毒碱生物碱如环圈子，festuclavine，agroclavine，chanoclavine和chanoclavine醛的微生物和方法，以及多肽，多核苷酸和包含这样的多核苷酸的载体，其可以用于制造棒状的方法 提供生物碱。

公开(公告)号：AU2022203048A1

公开(公告)日：2022-05-26

申请号：AU2022203048

申请日：2022-05-06

Applicant: EVOLVA SA

Inventor： HOUGHTON-LARSEN JENS ,  HICKS PAULA M ,  NAESBY MICHAEL ,  OSTERGAARD TANGE THOMAS ,  HANSEN JORGEN ,  DALGAARD MIKKELSEN MICHAEL ,  HALKJAER HANSEN ESBEN ,  SIMON ERNESTO ,  DE ANDRADE PEREIRA TAVARES SABINA

IPC: C12N9/00 ,  C12N9/10 ,  C12N9/90 ,  C12N15/81 ,  C12N15/82 ,  C12P15/00

Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A 5 and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.

公开(公告)号：AU2017258907A1

公开(公告)日：2017-11-30

申请号：AU2017258907

申请日：2017-11-09

Applicant: EVOLVA SA

Inventor： HOUGHTON-LARSEN JENS ,  HICKS PAULA M ,  NAESBY MICHAEL ,  OSTERGAARD TANGE THOMAS ,  HANSEN JORGEN ,  MICHAEL DALGAARD MIKKELSEN ,  HALKJAER HANSEN ESBEN ,  SIMON ERNESTO ,  DE ANDRADE PEREIRA TAVARES SABINA

IPC: C12N9/00 ,  C12N9/10 ,  C12N9/90 ,  C12N15/81 ,  C12N15/82 ,  C12P15/00

Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A 5 and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.

公开(公告)号：SG10201606565XA

公开(公告)日：2016-10-28

申请号：SG10201606565X

申请日：2012-08-08

Applicant: EVOLVA SA

Inventor： HOUGHTON-LARSEN JENS ,  HICKS PAULA M ,  NAESBY MICHAEL ,  OSTERGAARD TANGE THOMAS ,  HANSEN JORGEN ,  DALGAARD MIKKELSEN MICHAEL ,  HALKJAER HANSEN ESBEN ,  SIMON ERNESTO ,  DE ANDRADE PEREIRA TAVARES SABINA

Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.

公开(公告)号：SG10201606569VA

公开(公告)日：2016-09-29

申请号：SG10201606569V

申请日：2012-08-08

Applicant: EVOLVA SA

Inventor： HOUGHTON-LARSEN JENS ,  HICKS PAULA M ,  NAESBY MICHAEL ,  OSTERGAARD TANGE THOMAS ,  HANSEN JORGEN ,  DALGAARD MIKKELSEN MICHAEL ,  HALKJAER HANSEN ESBEN ,  SIMON ERNESTO ,  DE ANDRADE PEREIRA TAVARES SABINA

Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.

公开(公告)号：ZA201501883B

公开(公告)日：2019-08-28

申请号：ZA201501883

申请日：2015-03-19

Applicant: BASF SE ,  EVOLVA SA

Inventor： ZELDER OSKAR ,  HAEFNER STEFAN ,  SCHRÖDER HARTWIG ,  HOFF BIRGIT ,  MOLT ANDREA ,  DITRICH KLAUS ,  BREUER MICHAEL ,  HARTMANN HOLGER ,  KÖRBER KARSTEN ,  NAESBY MICHAEL ,  SCHWAB MARKUS ,  NIELSEN CURT AIMÉ FRIIS ,  FOLLY CHRISTOPHE ,  HATSCH ANAELLE

公开(公告)号：DK2885420T3

公开(公告)日：2019-03-25

申请号：DK13750348

申请日：2013-08-19

Applicant: EVOLVA SA

Inventor： NAESBY MICHAEL ,  FOLLY CHRISTOPHE ,  DELEGRANGE FANNY ,  HOUGHTON-LARSEN JENS ,  CARLSEN SIMON ,  TANGE THOMAS OESTERGAARD

IPC: C12P23/00 ,  C12N9/10 ,  C12N15/63 ,  C12P7/00

公开(公告)号：AU2013304001B2

公开(公告)日：2019-01-03

申请号：AU2013304001

申请日：2013-08-19

Applicant: EVOLVA SA

Inventor： TANGE THOMAS OESTERGAARD ,  NAESBY MICHAEL ,  FOLLY CHRISTOPHE ,  DELEGRANGE FANNY ,  HOUGHTON JENS ,  CARLSEN SIMON

IPC: C12N9/10 ,  C12N15/63 ,  C12P7/00 ,  C12P23/00

Abstract: This invention provides recombinant cells and methods for producing terpenes and terpenoids by increasing production or accumulation or both of isoprenoid precursors thereof.