公开(公告)号：WO2014122227A2

公开(公告)日：2014-08-14

申请号：PCT/EP2014052363

申请日：2014-02-06

Applicant: EVOLVA SA

Inventor： MIKKELSEN MICHAEL DALGAARD ,  HANSEN JORGEN ,  SIMON ERNESTO ,  BRIANZA FEDERICO ,  SEMMLER ANGELIKA ,  OLSSON KIM ,  CARLSEN SIMON ,  DÜRING LOUIS ,  OUSPENSKI ALEXEI ,  HICKS PAULA

IPC: A23L27/30 ,  C12N15/81

CPC classification number: C12P19/56 ,  A23L2/60 ,  A23L27/36 ,  A23V2002/00 ,  C12N9/0071 ,  C12N9/1051 ,  C12N9/1081 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/81 ,  C12Y204/01 ,  C12Y204/99

Abstract: Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided by this invention.

Abstract translation: 本发明提供了重组生产甜菊醇糖苷和含甜菊醇糖苷的组合物的方法。

公开(公告)号：WO2014122227A4

公开(公告)日：2014-12-18

申请号：PCT/EP2014052363

申请日：2014-02-06

Applicant: EVOLVA SA

Inventor： MIKKELSEN MICHAEL DALGAARD ,  HANSEN JORGEN ,  SIMON ERNESTO ,  BRIANZA FEDERICO ,  SEMMLER ANGELIKA ,  OLSSON KIM ,  CARLSEN SIMON ,  DÜRING LOUIS ,  OUSPENSKI ALEXEI ,  HICKS PAULA

IPC: A23L27/30 ,  C12N15/81 ,  A23L2/60 ,  C12N9/02 ,  C12N9/10 ,  C12N9/90 ,  C12P15/00

CPC classification number: C12P19/56 ,  A23L2/60 ,  A23L27/36 ,  A23V2002/00 ,  C12N9/0071 ,  C12N9/1051 ,  C12N9/1081 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/81 ,  C12Y204/01 ,  C12Y204/99

Abstract: Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided by this invention.

Abstract translation: 本发明提供了重组生产甜菊糖苷和含有甜菊糖苷的组合物的方法。

公开(公告)号：WO2014122227A8

公开(公告)日：2015-09-11

申请号：PCT/EP2014052363

申请日：2014-02-06

Applicant: EVOLVA SA

Inventor： MIKKELSEN MICHAEL DALGAARD ,  HANSEN JORGEN ,  SIMON ERNESTO ,  BRIANZA FEDERICO ,  SEMMLER ANGELIKA ,  OLSSON KIM ,  CARLSEN SIMON ,  DÜRING LOUIS ,  OUSPENSKI ALEXEI ,  HICKS PAULA

IPC: A23L27/30 ,  C12N15/81 ,  A23L2/60 ,  C12N9/02 ,  C12N9/10 ,  C12N9/90 ,  C12P15/00

CPC classification number: C12P19/56 ,  A23L2/60 ,  A23L27/36 ,  A23V2002/00 ,  C12N9/0071 ,  C12N9/1051 ,  C12N9/1081 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/81 ,  C12Y204/01 ,  C12Y204/99

Abstract: Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided by this invention.

公开(公告)号：WO2015028324A3

公开(公告)日：2015-04-23

申请号：PCT/EP2014067520

申请日：2014-08-15

Applicant: EVOLVA SA

Inventor： BAERENDS RICHARD JAN STEVEN ,  SIMON ERNESTO ,  MEYER JEAN PHILIPPE ,  VAZQUEZ CARLOS CASADO

IPC: C12N9/10 ,  C12N1/18 ,  C12P7/22 ,  C12P7/62

CPC classification number: C12P7/22 ,  C12N9/1007 ,  C12N9/1051 ,  C12P7/62 ,  C12P19/44 ,  C12Y201/00 ,  C12Y201/01 ,  C12Y204/00

Abstract: Methods for producing glycosylated and methylated resveratrol in a genetically engineered cell, by bioconversion,and in vitro are disclosed herein.

Abstract translation: 本文公开了通过生物转化和体外在遗传工程细胞中产生糖基化和甲基化的白藜芦醇的方法。

公开(公告)号：WO2014122227A9

公开(公告)日：2015-02-05

申请号：PCT/EP2014052363

申请日：2014-02-06

Applicant: EVOLVA SA

Inventor： MIKKELSEN MICHAEL DALGAARD ,  HANSEN JORGEN ,  SIMON ERNESTO ,  BRIANZA FEDERICO ,  SEMMLER ANGELIKA ,  OLSSON KIM ,  CARLSEN SIMON ,  DÜRING LOUIS ,  OUSPENSKI ALEXEI ,  HICKS PAULA

IPC: A23L27/30 ,  C12N15/81 ,  A23L2/60 ,  C12N9/02 ,  C12N9/10 ,  C12N9/90 ,  C12P15/00

CPC classification number: C12P19/56 ,  A23L2/60 ,  A23L27/36 ,  A23V2002/00 ,  C12N9/0071 ,  C12N9/1051 ,  C12N9/1081 ,  C12N9/1085 ,  C12N9/90 ,  C12N15/81 ,  C12Y204/01 ,  C12Y204/99

Abstract: Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided by this invention.

Abstract translation: 本发明提供了重组生产甜菊糖苷和含有甜菊糖苷的组合物的方法。

公开(公告)号：WO2014122328A1

公开(公告)日：2014-08-14

申请号：PCT/EP2014052675

申请日：2014-02-11

Applicant: EVOLVA SA

Inventor： SIMON ERNESTO ,  STØCKLER IBEN NORDMARK ,  MIKKELSEN MICHAEL DALGAARD ,  HANSEN JORGEN ,  DOUCHIN VERONIQUE

IPC: C12P15/00 ,  C07K14/395 ,  C12N9/10

CPC classification number: C12P19/56 ,  C07K14/395 ,  C12N9/0042 ,  C12N9/0073 ,  C12N9/1048 ,  C12N9/1051 ,  C12N9/1062 ,  C12N9/1085 ,  C12N9/88 ,  C12N9/90 ,  C12P15/00 ,  C12Y106/02004 ,  C12Y114/13078 ,  C12Y204/00 ,  C12Y204/01013 ,  C12Y204/01035 ,  C12Y205/01029 ,  C12Y402/03 ,  C12Y402/03019 ,  C12Y505/01013

Abstract: Recombinant microorganisms are disclosed that produce steviol glycosides and have altered expression of one or more endogenous transporter or transcription factor genes,or that overexpress one or more heterologous transporters, leading to increased excretionofsteviol glycosides ofinterest.

Abstract translation: 公开了重组微生物，其产生甜菊糖苷并且改变一种或多种内源性转运蛋白或转录因子基因的表达，或者过表达一种或多种异源转运蛋白，导致兴奋性的骨菌素糖苷的排泄增加。

公开(公告)号：WO2013022989A2

公开(公告)日：2013-02-14

申请号：PCT/US2012050021

申请日：2012-08-08

Applicant: EVOLVA SA ,  HOUGHTON-LARSEN JENS ,  HICKS PAULA M ,  NAESBY MICHAEL ,  OSTERGAARD TANGE THOMAS ,  HANSEN JORGEN ,  DALGAARD MIKKELSEN MICHAEL ,  HALKJAER HANSEN ESBEN ,  SIMON ERNESTO

Inventor： HOUGHTON-LARSEN JENS ,  HICKS PAULA M ,  NAESBY MICHAEL ,  OSTERGAARD TANGE THOMAS ,  HANSEN JORGEN ,  DALGAARD MIKKELSEN MICHAEL ,  HALKJAER HANSEN ESBEN ,  SIMON ERNESTO

IPC: C12N15/82

CPC classification number: C12P19/56 ,  C12N9/0032 ,  C12N9/0071 ,  C12N9/0073 ,  C12N9/1051 ,  C12N9/1085 ,  C12N9/88 ,  C12N9/90 ,  C12N15/63 ,  C12N15/81 ,  C12N15/8243 ,  C12P19/44 ,  Y02P20/52

Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.

Abstract translation: 公开了已经被工程化以表达编码UDP-糖基转移酶（UGT）的重组基因的重组微生物，植物和植物细胞。 这样的微生物，植物或植物细胞可以产生甜菊糖苷，例如雷鲍迪苷A和/或雷鲍迪苷D，其可以用作食品和膳食补充剂中的天然甜味剂。

公开(公告)号：CA2899276C

公开(公告)日：2022-11-01

申请号：CA2899276

申请日：2014-02-06

Applicant: EVOLVA SA

Inventor： MIKKELSEN MICHAEL DALGAARD ,  HANSEN JORGEN ,  SIMON ERNESTO ,  BRIANZA FEDERICO ,  SEMMLER ANGELIKA ,  OLSSON KIM ,  CARLSEN SIMON ,  DURING LOUIS ,  OUSPENSKI ALEXEI ,  HICKS PAULA

IPC: A23L27/30 ,  C12N15/81 ,  A23L2/60 ,  C12N9/02 ,  C12N9/10 ,  C12N9/90 ,  C12P15/00

Abstract: Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided by this invention.

公开(公告)号：AU2012294452B2

公开(公告)日：2017-08-10

申请号：AU2012294452

申请日：2012-08-08

Applicant: EVOLVA SA

Inventor： HOUGHTON-LARSEN JENS ,  HICKS PAULA M ,  NAESBY MICHAEL ,  OSTERGAARD TANGE THOMAS ,  HANSEN JORGEN ,  DALGAARD MIKKELSEN MICHAEL ,  HALKJAER HANSEN ESBEN ,  SIMON ERNESTO

IPC: C12N9/00 ,  C12N9/10 ,  C12N9/90 ,  C12N15/81 ,  C12N15/82 ,  C12P15/00

Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.

公开(公告)号：AU2016211124A1

公开(公告)日：2017-07-27

申请号：AU2016211124

申请日：2016-01-29

Applicant: EVOLVA SA

Inventor： OLSSON KIM ,  SIMON ERNESTO ,  DALGAARD MIKKELSEN MICHAEL ,  CARLSEN SIMON ,  DOUCHIN VERONIQUE ,  LIM SWEE CHUANG ,  DURING LOUIS

IPC: C12N9/10 ,  C12N1/18 ,  C12P15/00 ,  C12P19/56

Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides, glycosylated ent-kaurenol, and glycosylated ent-kaurenoic acid.