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公开(公告)号：WO2007092894A2
公开(公告)日：2007-08-16
申请号：PCT/US2007061787
申请日：2007-02-07
Applicant: EXOGENESIS CORP
Inventor： BLINN STEPHEN M , SVRLUGA RICHARD C
CPC classification number: A61L31/16 , A61F2/82 , A61F2250/0067 , A61L31/12 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/61 , A61L2300/62 , A61L2400/18 , C23C14/022 , C23C14/221 , C23C14/505 , H01J2237/0812 , Y10T428/249988 , Y10T428/31504
Abstract: Medical devices implanted or otherwise used in a mammal are made less prone to trigger adverse reactions by use of gas cluster ion-beam (GCIB) surface modification adhere various drug molecules directly into or onto the surface of medical devices, and optionally building adhered drug layers upon the first adhered layer to obtain a desired drug elution profile. This is accomplished without the need for a polymer or any other binding agent to retain the drug.
Abstract translation: 通过使用气体簇离子束（GCIB）表面改性将植入或以其他方式用于哺乳动物的医疗装置不易于引发不良反应，将各种药物分子直接粘附到医疗装置的表面或其上，并且可选地构建附着的药物层 在第一粘附层上获得所需的药物洗脱曲线。 这是在不需要聚合物或任何其它结合剂来保留药物的情况下完成的。
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公开(公告)号：CA3027990C
公开(公告)日：2021-06-01
申请号：CA3027990
申请日：2012-08-22
Applicant: EXOGENESIS CORP
Inventor： KIRKPATRICK SEAN R , SVRLUGA RICHARD C , BLINN STEPHEN M
Abstract: An apparatus and method provides a drug layer formed on a surface region of a medical device, the drug layer comprised of a drug deposition and a carbonized or densified layer formed from the drug deposition by irradiation on an outer surface of the drug deposition, wherein the carbonized or densified layer does not penetrate through the drug deposition and is adapted to release drug from the drug deposition at a predetermined rate.
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公开(公告)号：CA2845355C
公开(公告)日：2019-01-22
申请号：CA2845355
申请日：2012-08-22
Applicant: EXOGENESIS CORP
Inventor： KIRKPATRICK SEAN R , SVRLUGA RICHARD C , BLINN STEPHEN M
Abstract: An apparatus and method provides a drug layer formed on a surface region of a medical device, the drug layer comprised of a drug deposition and a carbonized or densified layer formed from the drug deposition by irradiation on an outer surface of the drug deposition, wherein the carbonized or densified layer does not penetrate through the drug deposition and is adapted to release drug from the drug deposition at a predetermined rate.
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公开(公告)号：CA2638020C
公开(公告)日：2016-09-27
申请号：CA2638020
申请日：2007-02-07
Applicant: EXOGENESIS CORP
Inventor： BLINN STEPHEN M , SVRLUGA RICHARD C
Abstract: Medical devices implanted or otherwise used in a mammal are made less prone to trigger adverse reactions by use of gas cluster ion-beam (GCIB) surface modification adhere various drug molecules directly into or onto the surface of medical devices, and optionally building adhered drug layers upon the first adhered layer to obtain a desired drug elution profile. This is accomplished without the need for a polymer or any other binding agent to retain the drug.
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公开(公告)号：CA2845355A1
公开(公告)日：2013-02-28
申请号：CA2845355
申请日：2012-08-22
Applicant: EXOGENESIS CORP
Inventor： KIRKPATRICK SEAN R , SVRLUGA RICHARD C , BLINN STEPHEN M
Abstract: An apparatus and method provides a drug layer formed on a surface region of a medical device, the drug layer comprised of a drug deposition and a carbonized or densified layer formed from the drug deposition by irradiation on an outer surface of the drug deposition, wherein the carbonized or densified layer does not penetrate through the drug deposition and is adapted to release drug from the drug deposition at a predetermined rate.
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Patent Agency Ranking
公开(公告)号：AU2016204279B2
公开(公告)日：2017-08-03
申请号：AU2016204279
申请日：2016-06-23
Applicant: EXOGENESIS CORP
Inventor： KIRKPATRICK SEAN R , SVRLUGA RICHARD C , BLINN STEPHEN M
Abstract: An apparatus and method provides a drug layer formed on a surface region of a medical device, the drug layer comprised of a drug deposition and a carbonized or densified layer formed from the drug deposition by irradiation on an outer surface of the drug deposition, wherein the 5 carbonized or densified layer does not penetrate through the drug deposition and is adapted to release drug from the drug deposition at a predetermined rate. WO 2013/028725 PCT/US20121051801 tz N yxx f .r x ... ik
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公开(公告)号：IL193283A
公开(公告)日：2013-12-31
申请号：IL19328308
申请日：2008-08-06
Applicant: EXOGENESIS CORP , BLINN STEPHEN M , SVRLUGA RICHARD C
Inventor： BLINN STEPHEN M , SVRLUGA RICHARD C
IPC: A61L20060101 , A61F2/82 , C23C20060101 , C23C14/02 , C23C14/22 , C23C14/50
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公开(公告)号：CA2845762A1
公开(公告)日：2013-10-28
申请号：CA2845762
申请日：2012-08-22
Applicant: EXOGENESIS CORP
Inventor： KIRKPATRICK SEAN R , SVRLUGA RICHARD C , BLINN STEPHEN M
Abstract: A method of modifying the surface of a medical device to release a drug in a controlled way by providing a barrier layer on the surface of one or more drug coatings. The barrier layer consists of modified drug material converted to a barrier layer by irradiation by an accelerated neutral beam derived from an accelerated gas cluster ion beam. Also medical devices formed thereby.
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公开(公告)号：CA2845762C
公开(公告)日：2019-01-08
申请号：CA2845762
申请日：2012-08-22
Applicant: EXOGENESIS CORP
Inventor： KIRKPATRICK SEAN R , SVRLUGA RICHARD C , BLINN STEPHEN M
Abstract: A method of modifying the surface of a medical device to release a drug in a controlled way by providing a barrier layer on the surface of one or more drug coatings. The barrier layer consists of modified drug material converted to a barrier layer by irradiation by an accelerated neutral beam derived from an accelerated gas cluster ion beam. Also medical devices formed thereby.
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公开(公告)号：AU2016204279A1
公开(公告)日：2016-07-14
申请号：AU2016204279
申请日：2016-06-23
Applicant: EXOGENESIS CORP
Inventor： KIRKPATRICK SEAN R , SVRLUGA RICHARD C , BLINN STEPHEN M
Abstract: An apparatus and method provides a drug layer formed on a surface region of a medical device, the drug layer comprised of a drug deposition and a carbonized or densified layer formed from the drug deposition by irradiation on an outer surface of the drug deposition, wherein the 5 carbonized or densified layer does not penetrate through the drug deposition and is adapted to release drug from the drug deposition at a predetermined rate. WO 2013/028725 PCT/US20121051801 tz N yxx f .r x ... ik
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