公开(公告)号：WO2009036373A2

公开(公告)日：2009-03-19

申请号：PCT/US2008076292

申请日：2008-09-12

Applicant: EXOGENESIS CORP

Inventor： KIRKPATRICK SEAN R ,  SVRLUGA RICHARD C

IPC: B05D3/00 ,  A61B19/00 ,  A61N1/18

CPC classification number: B05D3/068 ,  B05D3/104 ,  B05D5/00 ,  H01J2237/0812

Abstract: Irradiation of a surface of a material with a gas cluster ion beam modifies the wettability of the surface. The wettability may be increased or decreased dependent on the characteristics of the gas cluster ion beam. Improvements in wettability of a surface by the invention exceed those obtained by conventional plasma cleaning or etching. The improvements may be applied to surfaces of medical devices, such as vascular stents for example, and may be used to enable better wetting of medical device surfaces with liquid drugs in preparation for adhesion of the drug to the device surfaces, A mask may be used to limit processing to a portion of the surface. Medical devices formed by using the methods of the invention are disclosed.

Abstract translation: 用气体簇离子束照射材料的表面改变了表面的润湿性。 根据气体簇离子束的特性，润湿性可以增加或减少。 通过本发明的表面润湿性的改善超过了通过常规等离子体清洗或蚀刻获得的那些。 可以将改进应用于例如血管支架的医疗装置的表面，并且可用于使液体药物更好地润湿医疗装置表面，以准备将药物粘附到装置表面。可以使用掩模 以将处理限制到表面的一部分。 公开了通过使用本发明的方法形成的医疗装置。

公开(公告)号：WO2009158610A3

公开(公告)日：2010-03-04

申请号：PCT/US2009048846

申请日：2009-06-26

Applicant: EXOGENESIS CORP ,  KIRKPATRICK SEAN R ,  SVRLUGA RICHARD C

Inventor： KIRKPATRICK SEAN R ,  SVRLUGA RICHARD C

IPC: A61L2/14 ,  A61L2/20

CPC classification number: A61L2/087 ,  A61L2/20 ,  A61L12/10 ,  A61L2202/24 ,  H01J2237/0812

Abstract: Methods and systems for sterilization of objects by gas-cluster ion-beam (GCIB) irradiation are disclosed. The sterilization may be in conjunction with other beneficial GCIB surface processing of the objects. The objects may be medical devices or surgically implantable medical prostheses.

Abstract translation: 公开了通过气簇离子束（GCIB）照射灭菌物体的方法和系统。 灭菌可以与对象的其他有益的GCIB表面处理结合使用。 物体可以是医疗装置或可手术植入的医疗假体。

公开(公告)号：WO2009046093A3

公开(公告)日：2009-05-28

申请号：PCT/US2008078429

申请日：2008-10-01

Applicant: EXOGENESIS CORP ,  KIRKPATRICK SEAN R ,  SVRLUGA RICHARD C

Inventor： KIRKPATRICK SEAN R ,  SVRLUGA RICHARD C

IPC: B05D3/00 ,  A61F2/82 ,  B05C13/02 ,  C23C14/00

CPC classification number: B05D1/02 ,  A61F2/82 ,  A61F2240/001 ,  B05B5/08 ,  B05D3/0493 ,  B05D3/06 ,  B05D3/107 ,  B05D3/145 ,  H01J37/3053 ,  H01J2237/0812 ,  H01J2237/3151

Abstract: A multi-layer drug coated medical device such as for example an expandable vascular drug eluting stent is formed by vacuum pulse spray techniques wherein each layer is irradiated to improve adhesion and/or drug elution properties prior to formation of subsequent layers. Layers may be homogeneous or of diverse drugs. Layers may incorporate a non-polymer elution-retarding material. Layers may alternate with one or more layers of non-polymer elution-retarding materials. Polymer binders and/or matrices are not used in the formation of the coatings, yet the pure drug coatings have good mechanical and elution rate properties. Systems, methods and medical device articles are disclosed.

Abstract translation: 通过真空脉冲喷雾技术形成多层药物涂覆的医疗装置，例如可扩张血管药物洗脱支架，其中每层照射以在形成后续层之前提高粘附性和/或药物洗脱性质。 层可能是同质的或不同的药物。 层可以掺入非聚合物洗脱阻滞材料。 层可以与一层或多层非聚合物洗脱阻滞材料交替。 聚合物粘合剂和/或基质不用于涂层的形成，但纯药物涂层具有良好的机械和洗脱速率性能。 公开了系统，方法和医疗装置的物品。

公开(公告)号：WO2009100006A3

公开(公告)日：2009-10-01

申请号：PCT/US2009032841

申请日：2009-02-02

Applicant: EXOGENESIS CORP ,  SVRLUGA RICHARD C ,  KIRKPATRICK SEAN R

Inventor： SVRLUGA RICHARD C ,  KIRKPATRICK SEAN R

IPC: C23F4/00 ,  A61B17/3211

CPC classification number: A61B17/3209 ,  A61B2017/00526 ,  A61B2017/00831 ,  C23C14/0641 ,  C23C14/221 ,  H01J2237/0812

Abstract: Methods and systems for the improvement of a crystalline and/or poly-crystalline surgical blade include gas cluster ion beam irradiation of the blades in order to smooth; or to sharpen; or to reduce the brittleness and thus reduce susceptibility of the blade to crack, chip, or fracture; or to render the blades hydrophilic. Crystalline or poly-crystalline surgical blade (silicon for example) having a thin film cutting edge with improved properties.

Abstract translation: 用于改善结晶和/或多晶外科手术刀片的方法和系统包括叶片的气体簇离子束照射以平滑; 或锐化 或降低脆性，从而降低刀片的裂纹，碎裂或断裂的敏感性; 或使刮片呈亲水性。 具有提高性能的薄膜切割边缘的结晶或多晶外科刀片（例如硅）。

公开(公告)号：WO2007092894A2

公开(公告)日：2007-08-16

申请号：PCT/US2007061787

申请日：2007-02-07

Applicant: EXOGENESIS CORP

Inventor： BLINN STEPHEN M ,  SVRLUGA RICHARD C

IPC: A61F2/82 ,  C23C14/02 ,  C23C14/22 ,  C23C14/50

CPC classification number: A61L31/16 ,  A61F2/82 ,  A61F2250/0067 ,  A61L31/12 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/426 ,  A61L2300/61 ,  A61L2300/62 ,  A61L2400/18 ,  C23C14/022 ,  C23C14/221 ,  C23C14/505 ,  H01J2237/0812 ,  Y10T428/249988 ,  Y10T428/31504

Abstract: Medical devices implanted or otherwise used in a mammal are made less prone to trigger adverse reactions by use of gas cluster ion-beam (GCIB) surface modification adhere various drug molecules directly into or onto the surface of medical devices, and optionally building adhered drug layers upon the first adhered layer to obtain a desired drug elution profile. This is accomplished without the need for a polymer or any other binding agent to retain the drug.

Abstract translation: 通过使用气体簇离子束（GCIB）表面改性将植入或以其他方式用于哺乳动物的医疗装置不易于引发不良反应，将各种药物分子直接粘附到医疗装置的表面或其上，并且可选地构建附着的药物层 在第一粘附层上获得所需的药物洗脱曲线。 这是在不需要聚合物或任何其它结合剂来保留药物的情况下完成的。

公开(公告)号：KR20180070505A

公开(公告)日：2018-06-26

申请号：KR20177022105

申请日：2016-07-22

Applicant: EXOGENESIS CORP

Inventor： KIRKPATRICK SEAN R ,  SVRLUGA RICHARD C

IPC: H01L21/3065 ,  H01L21/02 ,  H01L21/306 ,  H01L21/311

CPC classification number: H01L21/32134 ,  C03C15/00 ,  H01J2237/061 ,  H01J2237/0812 ,  H01L21/02115 ,  H01L21/02167 ,  H01L21/02227 ,  H01L21/02238 ,  H01L21/02252 ,  H01L21/02274 ,  H01L21/02326 ,  H01L21/0234 ,  H01L21/30604 ,  H01L21/3065 ,  H01L21/3086 ,  H01L21/3105 ,  H01L21/31105 ,  H01L21/31111 ,  H01L21/31116 ,  H01L21/321

Abstract: 본발명의기판표면의초미세에칭방법은가속된중성빔을이용하여비개질기판상을오버레이하는얕은개질된기판층을형성하고, 개질층을에칭하며, 그아래의비개질기판에서정지하여제어된얕은에칭된기판표면을생성한다.

公开(公告)号：WO2013096255A3

公开(公告)日：2015-07-09

申请号：PCT/US2012070254

申请日：2012-12-18

Applicant: EXOGENESIS CORP ,  KHOURY JOSEPH ,  TARRANT LAURENCE B ,  KIRKPATRICK SEAN R ,  SVRLUGA RICHARD C ,  DOSHI KSHAMA J

Inventor： KHOURY JOSEPH ,  TARRANT LAURENCE B ,  KIRKPATRICK SEAN R ,  SVRLUGA RICHARD C ,  DOSHI KSHAMA J

IPC: C23C16/00 ,  C23C16/50

CPC classification number: A61L27/24 ,  A61L17/08 ,  A61L17/10 ,  A61L17/14 ,  A61L27/3604 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/56 ,  A61L2400/18 ,  G21K5/04 ,  C08L89/06

Abstract: A method for improving bioactivity and/or biodegradation time of a collagen surgical implant and collagen surgical implants having such improved properties. A gas-cluster ion-beam (GCIB) is formed in a reduced-pressure chamber, a collagen surgical implant is introduced into the reduced-pressure chamber, and at least a first portion of the surface of said collagen surgical implant is irradiated with a GCIB-derived beam.

Abstract translation: 一种用于改善具有这种改善的性质的胶原手术植入物和胶原外科植入物的生物活性和/或生物降解时间的方法。 在减压室中形成气体簇离子束（GCIB），将胶原外科植入物引入减压室中，并且将所述胶原外科植入物的表面的至少第一部分用 GCIB衍生光束。

公开(公告)号：WO2010017451A3

公开(公告)日：2010-07-01

申请号：PCT/US2009053108

申请日：2009-08-07

Applicant: EXOGENESIS CORP ,  SVRLUGA RICHARD C ,  TARRANT LAURENCE B

Inventor： SVRLUGA RICHARD C ,  TARRANT LAURENCE B

IPC: A61L27/28 ,  A61L27/04 ,  A61L27/54

CPC classification number: A61F2/28 ,  A61C8/0012 ,  A61C8/0018 ,  A61F2/30771 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2002/30795 ,  A61F2250/0068 ,  A61F2310/00796 ,  A61L27/10 ,  A61L27/50 ,  A61L27/54 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/45 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2400/18 ,  B05D3/068 ,  C23C14/221 ,  C23C14/48

Abstract: A bone implantable medical device made from a biocompatible material, preferably comprising titania or zirconia, has at least a portion of its surface modified to facilitate improved integration with bone. The implantable device may incorporate a surface infused with osteoinductive agent and/or may incorporate holes loaded with a therapeutic agent. The infused surface and/or the holes may be patterned to determine the distribution of and amount of osteoinductive agent and/or therapeutic agent incorporated. The rate of release or elution profile of the therapeutic agent may be controlled. Methods for producing such a bone implantable medical device are also disclosed and employ the use of ion beam irradiation, preferably gas cluster ion beam irradiation for improving bone integration.

Abstract translation: 由生物相容性材料（优选包含二氧化钛或氧化锆）制成的骨可植入医疗装置的表面的至少一部分被改性以促进与骨整合。 可植入装置可包含注入骨诱导剂的表面和/或可结合装载有治疗剂的孔。 注入表面和/或孔可以被图案化以确定掺入的骨诱导剂和/或治疗剂的分布和量。 可以控制治疗剂的释放速率或洗脱曲线。 还公开了用于生产这种骨植入式医疗装置的方法，并且使用离子束照射，优选用于改善骨整合的气体团簇离子束照射。

公开(公告)号：WO2010017456A2

公开(公告)日：2010-02-11

申请号：PCT/US2009053113

申请日：2009-08-07

Applicant: EXOGENESIS CORP ,  SVRLUGA RICHARD C

Inventor： SVRLUGA RICHARD C ,  KIRKPATRICK SEAN R

IPC: A61L27/54 ,  A61F2/02 ,  A61F2/04 ,  A61F2/82 ,  A61L27/50

CPC classification number: A61F2/91 ,  A61F2002/30064 ,  A61F2210/0076 ,  A61F2250/0068 ,  B23K26/382 ,  B23K26/389 ,  B23K26/40 ,  B23K2203/05 ,  B23K2203/08 ,  B23K2203/14 ,  B23K2203/15 ,  B23K2203/26 ,  B23K2203/42 ,  B23K2203/50 ,  B23K2203/52

Abstract: A medical device for surgical implantation adapted to serve as a drug delivery system has one or more drug loaded holes with barrier layers to control release or elution of the drug from the holes or to control inward diffusion of fluids into the holes. The barrier layers are non-polymers and are formed from the drug material itself by ion beam processing. The holes may be in patterns to spatially control drug delivery. Flexible options permit combinations of drugs, variable drug dose per hole, multiple drugs per hole, temporal control of drug release sequence and profile. Methods for forming such a drug delivery system are also disclosed.

Abstract translation: 用于手术植入的医疗装置适于用作药物递送系统，其具有带有阻挡层的一个或多个载有药物的孔，以控制药物从孔释放或洗脱或控制流体向孔内的扩散。 阻挡层是非聚合物并且由药物材料本身通过离子束处理形成。 这些孔可以用图案来空间控制药物输送。 灵活的选择允许药物组合，每孔可变药物剂量，每孔多种药物，药物释放顺序和分布的时间控制。 还公开了形成这种药物递送系统的方法。

公开(公告)号：CA3027990C

公开(公告)日：2021-06-01

申请号：CA3027990

申请日：2012-08-22

Applicant: EXOGENESIS CORP

Inventor： KIRKPATRICK SEAN R ,  SVRLUGA RICHARD C ,  BLINN STEPHEN M

IPC: A61L31/16 ,  A61L31/08 ,  A61M31/00

Abstract: An apparatus and method provides a drug layer formed on a surface region of a medical device, the drug layer comprised of a drug deposition and a carbonized or densified layer formed from the drug deposition by irradiation on an outer surface of the drug deposition, wherein the carbonized or densified layer does not penetrate through the drug deposition and is adapted to release drug from the drug deposition at a predetermined rate.