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    METHOD AND SYSTEM FOR MODIFYING THE WETTABILITY CHARACTERISTICS OF A SURFACE OF A MEDICAL DEVICE BY THE APPLICATION OF GAS CLUSTER ION BEAM TECHNOLOGY AND MEDICAL DEVICES MADE THEREBY
    1.
    发明申请
    METHOD AND SYSTEM FOR MODIFYING THE WETTABILITY CHARACTERISTICS OF A SURFACE OF A MEDICAL DEVICE BY THE APPLICATION OF GAS CLUSTER ION BEAM TECHNOLOGY AND MEDICAL DEVICES MADE THEREBY 审中-公开
    通过应用气体离子束技术和医疗器械改造医疗器械表面的湿度特性的方法和系统

    公开(公告)号：WO2009036373A2

    公开(公告)日：2009-03-19

    申请号：PCT/US2008076292

    申请日：2008-09-12

    Applicant: EXOGENESIS CORP

    Inventor： KIRKPATRICK SEAN R ,  SVRLUGA RICHARD C

    IPC: B05D3/00 ,  A61B19/00 ,  A61N1/18

    CPC classification number: B05D3/068 ,  B05D3/104 ,  B05D5/00 ,  H01J2237/0812

    Abstract: Irradiation of a surface of a material with a gas cluster ion beam modifies the wettability of the surface. The wettability may be increased or decreased dependent on the characteristics of the gas cluster ion beam. Improvements in wettability of a surface by the invention exceed those obtained by conventional plasma cleaning or etching. The improvements may be applied to surfaces of medical devices, such as vascular stents for example, and may be used to enable better wetting of medical device surfaces with liquid drugs in preparation for adhesion of the drug to the device surfaces, A mask may be used to limit processing to a portion of the surface. Medical devices formed by using the methods of the invention are disclosed.

    Abstract translation: 用气体簇离子束照射材料的表面改变了表面的润湿性。 根据气体簇离子束的特性，润湿性可以增加或减少。 通过本发明的表面润湿性的改善超过了通过常规等离子体清洗或蚀刻获得的那些。 可以将改进应用于例如血管支架的医疗装置的表面，并且可用于使液体药物更好地润湿医疗装置表面，以准备将药物粘附到装置表面。可以使用掩模 以将处理限制到表面的一部分。 公开了通过使用本发明的方法形成的医疗装置。

    METHOD AND SYSTEM FOR COATING A SURFACE OF A MEDICAL DEVICE WITH A THERAPEUTIC AGENT AND DRUG ELUTING MEDICAL DEVICES MADE THEREBY
    4.
    发明申请
    METHOD AND SYSTEM FOR COATING A SURFACE OF A MEDICAL DEVICE WITH A THERAPEUTIC AGENT AND DRUG ELUTING MEDICAL DEVICES MADE THEREBY 审中-公开
    用于将医疗装置的表面与治疗剂和药物给药的方法和系统相结合

    公开(公告)号：WO2009046093A3

    公开(公告)日：2009-05-28

    申请号：PCT/US2008078429

    申请日：2008-10-01

    Applicant: EXOGENESIS CORP ,  KIRKPATRICK SEAN R ,  SVRLUGA RICHARD C

    Inventor： KIRKPATRICK SEAN R ,  SVRLUGA RICHARD C

    IPC: B05D3/00 ,  A61F2/82 ,  B05C13/02 ,  C23C14/00

    CPC classification number: B05D1/02 ,  A61F2/82 ,  A61F2240/001 ,  B05B5/08 ,  B05D3/0493 ,  B05D3/06 ,  B05D3/107 ,  B05D3/145 ,  H01J37/3053 ,  H01J2237/0812 ,  H01J2237/3151

    Abstract: A multi-layer drug coated medical device such as for example an expandable vascular drug eluting stent is formed by vacuum pulse spray techniques wherein each layer is irradiated to improve adhesion and/or drug elution properties prior to formation of subsequent layers. Layers may be homogeneous or of diverse drugs. Layers may incorporate a non-polymer elution-retarding material. Layers may alternate with one or more layers of non-polymer elution-retarding materials. Polymer binders and/or matrices are not used in the formation of the coatings, yet the pure drug coatings have good mechanical and elution rate properties. Systems, methods and medical device articles are disclosed.

    Abstract translation: 通过真空脉冲喷雾技术形成多层药物涂覆的医疗装置，例如可扩张血管药物洗脱支架，其中每层照射以在形成后续层之前提高粘附性和/或药物洗脱性质。 层可能是同质的或不同的药物。 层可以掺入非聚合物洗脱阻滞材料。 层可以与一层或多层非聚合物洗脱阻滞材料交替。 聚合物粘合剂和/或基质不用于涂层的形成，但纯药物涂层具有良好的机械和洗脱速率性能。 公开了系统，方法和医疗装置的物品。

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