公开(公告)号：WO2014055219A2

公开(公告)日：2014-04-10

申请号：PCT/US2013059640

申请日：2013-09-13

Applicant: FLODESIGN SONICS INC

Inventor： LIPKENS BART ,  DIONNE JASON ,  PRESZ JR WALTER ,  KENNEDY III THOMAS J

IPC: B01D43/00 ,  B06B1/06

CPC classification number: B06B1/06 ,  B06B2201/70 ,  C12M47/02

Abstract: A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.

Abstract translation: 描述了通过操纵超声换能器的频率来改善捕获力的方法，其具有改善的吸引力的捕集力。 换能器包括陶瓷晶体。 晶体可能直接暴露于流体流动。 晶体可能是空气支撑的，导致更高的Q因子。

公开(公告)号：AU2019232037B2

公开(公告)日：2022-05-19

申请号：AU2019232037

申请日：2019-03-11

Applicant: FLODESIGN SONICS INC

Inventor： LIPKENS BART ,  GHOSHAL GOUTAM ,  MANZI NICHOLAS ,  KENNEDY III THOMAS J ,  TOSTOES RUI ,  ROSS-JOHNSRUD BENJAMIN

IPC: C12N15/63 ,  A61M37/00 ,  C12M1/42 ,  C12N15/86

Abstract: Methods for introducing foreign nucleic acids into cells, such as by performing transfection / transduction, using acoustic processes are disclosed herein. The foreign DNA/RNA and the cells are co-located in a multi-dimensional acoustic standing wave, or are co-located by acoustic streaming.

公开(公告)号：SG11201405693PA

公开(公告)日：2014-10-30

申请号：SG11201405693P

申请日：2013-03-15

Applicant: FLODESIGN SONICS INC

Inventor： LIPKENS BART ,  DIONNE JASON ,  KENNEDY III THOMAS J ,  MASI LOUIS ,  KOWALSKI III STANLEY

IPC: B01D43/00

Abstract: A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.

公开(公告)号：AU2019232037A1

公开(公告)日：2020-05-21

申请号：AU2019232037

申请日：2019-03-11

Applicant: FLODESIGN SONICS INC

Inventor： LIPKENS BART ,  GHOSHAL GOUTAM ,  MANZI NICHOLAS ,  KENNEDY III THOMAS J ,  TOSTOES RUI ,  ROSS-JOHNSRUD BENJAMIN

IPC: A61M37/00 ,  C12M1/42 ,  C12N15/86

Abstract: Methods for introducing foreign nucleic acids into cells, such as by performing transfection / transduction, using acoustic processes are disclosed herein. The foreign DNA/RNA and the cells are co-located in a multi-dimensional acoustic standing wave, or are co-located by acoustic streaming.

公开(公告)号：EP3019606A4

公开(公告)日：2017-04-05

申请号：EP14823682

申请日：2014-07-11

Applicant: FLODESIGN SONICS INC

Inventor： KENNEDY III THOMAS J ,  LIPKENS BART ,  MASI LOUIS ,  KOWALSKI III STANLEY ,  LEIDEL CHRIS

IPC: C12N13/00 ,  B06B1/02 ,  B06B1/06 ,  C07K1/14 ,  C12M1/00 ,  C12P21/02

CPC classification number: C12N13/00 ,  B06B1/0238 ,  B06B1/0648 ,  B06B2201/76 ,  C07K1/145 ,  C12M47/02 ,  C12P21/02

Abstract: A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. Biomolecules produced by the cell culture are collected by the nutrient fluid stream and separated downstream of the cell culture.

Abstract translation: 在生物反应器的生长体积内建立一系列多维声驻波。 声波驻波被用于将细胞培养物保持在适当位置，因为营养液流流过细胞培养物。 通过营养液流收集由细胞培养产生的生物分子，并在细胞培养物的下游分离。

公开(公告)号：EP2903715A4

公开(公告)日：2016-10-05

申请号：EP13844181

申请日：2013-09-13

Applicant: FLODESIGN SONICS INC

Inventor： LIPKENS BART ,  DIONNE JASON ,  PRESZ JR WALTER ,  KENNEDY III THOMAS J

IPC: B01D17/04 ,  C02F1/36 ,  C02F1/40

CPC classification number: B06B1/06 ,  B06B2201/70 ,  C12M47/02

Abstract: A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.

公开(公告)号：EP2825279A4

公开(公告)日：2016-03-09

申请号：EP13760840

申请日：2013-03-15

Applicant: FLODESIGN SONICS INC

Inventor： LIPKENS BART ,  DIONNE JASON ,  KENNEDY III THOMAS J ,  MASI LOUIS ,  KOWALSKI III STANLEY

IPC: B01D17/04 ,  B01D43/00 ,  C02F1/36 ,  C02F1/40

CPC classification number: B01D43/00 ,  B06B1/0644 ,  C12M47/02

Abstract: A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.