公开(公告)号：CA2918036C

公开(公告)日：2018-04-24

申请号：CA2918036

申请日：2014-07-11

Applicant: FLODESIGN SONICS INC

Inventor： KENNEDY THOMAS J ,  LIPKENS BART ,  MASI LOUIS ,  KOWALSKI STANLEY ,  LEIDEL CHRIS

IPC: C12N13/00 ,  C12M1/42 ,  C12M3/00 ,  C12N5/071 ,  C12P21/00

Abstract: A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. Biomolecules produced by the cell culture are collected by the nutrient fluid stream and separated downstream of the cell culture.

公开(公告)号：CA3034208A1

公开(公告)日：2018-02-22

申请号：CA3034208

申请日：2016-08-16

Applicant: FLODESIGN SONICS INC

Inventor： LIPKENS BART ,  MASI LOUIS ,  KOWALSKI STANLEY ,  PRESZ WALTER M ,  DIONNE JASON ,  DUTRA BRIAN ,  MERCADO ARI ,  KENNEDY THOMAS J ,  MARTIN ARTHUR

IPC: C12M1/00 ,  B01D21/28

Abstract: A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.

公开(公告)号：CA2918036A1

公开(公告)日：2015-01-15

申请号：CA2918036

申请日：2014-07-11

Applicant: FLODESIGN SONICS INC

Inventor： KENNEDY THOMAS J III ,  LIPKENS BART ,  MASI LOUIS ,  KOWALSKI STANLEY III ,  LEIDEL CHRIS

IPC: C12N13/00 ,  C12M1/00

Abstract: A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. Biomolecules produced by the cell culture are collected by the nutrient fluid stream and separated downstream of the cell culture.

公开(公告)号：CA2909950A1

公开(公告)日：2014-10-30

申请号：CA2909950

申请日：2014-04-25

Applicant: FLODESIGN SONICS INC

Inventor： LIPKENS BART ,  MERCADO ARI ,  MARTIN ARTHUR ,  MASI LOUIS ,  DIONNE JASON

IPC: B01D11/00

Abstract: Active pharmaceutical ingredients can be separated from their excipients by dissolving a pharmaceutical product (e.g. tablet, pill) into a solvent, then running the solution through an acoustophoretic device. Standing waves are used to separate the excipient from the active ingredient dissolved in the solvent.

公开(公告)号：CA2994643A1

公开(公告)日：2018-08-14

申请号：CA2994643

申请日：2018-02-12

Applicant: FLODESIGN SONICS INC

Inventor： LIPKENS BART ,  MASI LOUIS ,  KOWALSKI STANLEY ,  PRESZ WALTER M JR ,  DIONNE JASON ,  DUTRA BRIAN ,  MERCADO ARI ,  KENNEDY THOMAS J ,  MARTIN ARTHUR ,  ROZEMBERSKY JOHN

IPC: C12M1/42 ,  C07K1/14 ,  C12M1/12 ,  C12P1/00 ,  C12P21/02 ,  C12P21/08

Abstract: A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.

公开(公告)号：CA2942331A1

公开(公告)日：2015-09-17

申请号：CA2942331

申请日：2015-03-10

Applicant: FLODESIGN SONICS INC

Inventor： LIPKENS BART ,  MASI LOUIS ,  PRESZ WALTER M JR ,  KENNEDY THOMAS J III

IPC: C12M1/00 ,  B01D15/38 ,  C12M1/06

Abstract: A disposable bioreactor system includes a bag having a first end and a second end. An acoustophoresis device is disposed at the first end of the bag, and is separable from the bag. An actuating mechanism is operably connected to the second end of the bag. The actuating mechanism is configured to move the second end of the bag towards the acoustophoresis device, so that fluids within the volume of the bag flow past the acoustophoresis device and carry desired biomolecules out of the bag for collection, while cells and other debris remain within the bag for disposal.

公开(公告)号：CA2926200A1

公开(公告)日：2015-05-14

申请号：CA2926200

申请日：2014-11-05

Applicant: FLODESIGN SONICS INC

Inventor： LIPKENS BART ,  BARNES JASON ,  MEALEY DANE ,  PRESZ WALTER M JR ,  KOWALSKI STANLEY III ,  MASI LOUIS ,  KENNEDY THOMAS J III ,  MCCARTHY BRIAN ,  ROSS-JOHNSRUD BEN

IPC: A61M1/36 ,  B60B1/00 ,  C12M1/00 ,  C12M1/26

Abstract: An acoustophoresis device made up of modular components is disclosed. Several modules are disclosed herein, including ultrasonic transducer modules, input/output modules, collection well modules, and various connector modules. These permit different systems to be constructed that have appropriate fluid dynamics for separation of particles, such as biological cells, from a fluid.

公开(公告)号：CA2879365A1

公开(公告)日：2014-01-23

申请号：CA2879365

申请日：2013-07-16

Applicant: FLODESIGN SONICS INC

Inventor： LIPKENS BART ,  DIONNE JASON ,  MERCADO ARI ,  DUTRA BRIAN ,  PRESZ WALTER JR ,  MASI LOUIS ,  KENNEDY THOMAS J III

IPC: B01D17/04 ,  C02F1/36 ,  C02F1/40

Abstract: An acoustic standing wave is utilized to separate components from a multi- component fluid, such as oil from an oil-water mixture, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water.

公开(公告)号：SG11201405693PA

公开(公告)日：2014-10-30

申请号：SG11201405693P

申请日：2013-03-15

Applicant: FLODESIGN SONICS INC

Inventor： LIPKENS BART ,  DIONNE JASON ,  KENNEDY III THOMAS J ,  MASI LOUIS ,  KOWALSKI III STANLEY

IPC: B01D43/00

Abstract: A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.

公开(公告)号：CA2900277A1

公开(公告)日：2014-08-14

申请号：CA2900277

申请日：2014-02-07

Applicant: FLODESIGN SONICS INC

Inventor： LIPKENS BART ,  MASI LOUIS ,  KOWALSKI STANLEY III ,  PRESZ WALTER M JR ,  DIONNE JASON ,  DUTRA BRIAN ,  KENNEDY THOMAS III ,  MARTIN ARTHUR ,  MERCADO ARI

IPC: B01D21/28

Abstract: A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor. The bioreactor includes a reaction vessel, an agitator, a feed inlet, and an outlet. A filtering device is included that has an inlet, a flow chamber and a sleeve surrounding the flow chamber, where the sleeve includes the ultrasonic transducer.