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公开(公告)号：WO2020150236A1
公开(公告)日：2020-07-23
申请号：PCT/US2020/013509
申请日：2020-01-14
Applicant: FLUIDIGM CANADA INC. , FLUIDIGM CORPORATION
Inventor： LOBODA, Alexander , SANDKUIJL, Daaf , CAREW, Adam
IPC: C12Q1/6872 , G01N27/62 , G01N33/48 , H01J49/00
Abstract: As described herein, one or more parameters of a direct ionization imaging mass spectrometer (IMS) may be set to obtain a desired plasma and deliver it to a mass detector. Depending on the application, certain parameters may be predetermined (e.g., a spot size given a desired resolution) and, as described herein, other parameters can be adjusted to obtain the desired plasma properties. Also included is sample preparation suitable for direct ionization IMS and/or other imaging modalities.
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公开(公告)号：WO2020055813A1
公开(公告)日：2020-03-19
申请号：PCT/US2019/050333
申请日：2019-09-10
Applicant: FLUIDIGM CANADA INC. , FLUIDIGM CORPORATION
Inventor： SANDKUIJL, Daaf , LOBODA, Alexander , CAREW, Adam , LAKSHMAN, Minalini
Abstract: This disclosure relates to systems and methods for high speed modulation sample imaging. Disclosed herein are systems and methods for performing imaging mass cytometry, including analysis of labelling atoms by elemental (e.g., atomic) mass spectrometry. Aspects include a sampling system having, and method of using, a femtosecond (fs) laser and/or laser scanning. Alternatively or in addition, aspects include systems and methods for co-registering other imaging modalities with imaging mass cytometry.
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公开(公告)号：WO2020055810A1
公开(公告)日：2020-03-19
申请号：PCT/US2019/050330
申请日：2019-09-10
Applicant: FLUIDIGM CANADA INC. , FLUIDIGM CORPORATION
Inventor： SANDKUIJL, Daaf , LOBODA, Alexander , CAREW, Adam , ASKARPOUR, Khashayar
Abstract: The invention relates to systems and methods for autofocusing in imaging mass spectrometry. The present invention provides improvements over current IMS and IMG apparatus and methods through an autofocus component including plurality of apertures in the autofocus system, such as a plurality of apertures arranged in 2 dimensions. As a plurality of apertures is used the autofocus system provides redundancy in the event that measurement of focus on the sample from the illuminating radiation passed through one or more of the apertures fails so reducing the number of unsuccessful autofocus attempts.
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公开(公告)号：WO2021127657A1
公开(公告)日：2021-06-24
申请号：PCT/US2020/066488
申请日：2020-12-21
Applicant: FLUIDIGM CANADA INC.
Inventor： CAREW, Adam , SANDKUIJL, Daaf , LOBODA, Alexander , WEEL, Matthew , BANDURA, Dmitry
Abstract: Described herein are systems and methods for imaging mass spectrometry, including imaging mass cytometry. Aspects of the subject application include apparatus and methods for imaging mass spectrometry (IMS) that improve speed of sample acquisition, signal sensitivity, and/or signal stability. Systems and methods described herein may minimize the transfer time and/or may minimize the spread of plumes of sample material ablated from a sample to be transferred to the components of the imaging mass spectrometer or mass cytometer that ionize and analyze the sample material.
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公开(公告)号：WO2021108584A1
公开(公告)日：2021-06-03
申请号：PCT/US2020/062268
申请日：2020-11-25
Applicant: FLUIDIGM CANADA INC.
Inventor： SANDKUIJL, Daaf , LOBODA, Alexander , YEH, Vincent Yi-Ching , GHEIRATMAND, Ladan
Abstract: Methods and systems for automated slide handling for imaging applications are described herein. In certain aspects, an automated slide handler may be operatively coupled to a slide hotel and/or one or more imaging systems described herein. The automated slide handler may be a robotic arm with up to 6 degrees of freedom. Automated slide handling may include sample preparation, such as sectioning and staining. Suitable imaging systems include a fluorescence microscope or an imaging mass cytometer. Methods and systems disclosed herein enable high throughput profiling of tissue sections.
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Patent Agency Ranking
公开(公告)号：EP3911760A1
公开(公告)日：2021-11-24
申请号：EP20741427.7
申请日：2020-01-14
Applicant: Fluidigm Canada Inc.
Inventor： LOBODA, Alexander , SANDKUIJL, Daaf , CAREW, Adam
IPC: C12Q1/6872 , G01N27/62 , G01N33/48 , H01J49/00
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公开(公告)号：EP3850656A1
公开(公告)日：2021-07-21
申请号：EP19860427.4
申请日：2019-09-10
Applicant: Fluidigm Canada Inc.
Inventor： SANDKUIJL, Daaf , LOBODA, Alexander , CAREW, Adam , LAKSHMAN, Minalini
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公开(公告)号：EP3850329A1
公开(公告)日：2021-07-21
申请号：EP19859992.0
申请日：2019-09-10
Applicant: Fluidigm Canada Inc.
Inventor： SANDKUIJL, Daaf , LOBODA, Alexander , CAREW, Adam , ASKARPOUR, Khashayar
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公开(公告)号：WO2021101893A1
公开(公告)日：2021-05-27
申请号：PCT/US2020/060892
申请日：2020-11-17
Applicant: FLUIDIGM CORPORATION
Inventor： SANDKUIJL, Daaf , CARPINO, Alan
Abstract: A microscopy apparatus comprises a microscope comprising a stage configured to hold a tissue sample, a UV laser assembly configured to emit a UV laser beam to a viewing area of the tissue sample, and an IR laser assembly configured to emit an IR laser beam to the viewing area of the tissue sample. The UV and IR laser assemblies are oriented so as to emit the respective UV and IR laser beams in a same direction.
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公开(公告)号：EP4062221A1
公开(公告)日：2022-09-28
申请号：EP20889422.0
申请日：2020-11-17
Applicant: Fluidigm Corporation
Inventor： SANDKUIJL, Daaf , CARPINO, Alan
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