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公开(公告)号：WO2019200307A1
公开(公告)日：2019-10-17
申请号：PCT/US2019/027306
申请日：2019-04-12
Applicant: FLUIDIGM CANADA INC. , FLUIDIGM CORPORATION
Inventor： BARANOV, Vladimir , LOBODA, Alexander , SULLIVAN, Michael
IPC: G01N33/50 , G01N33/532 , G01N33/543 , G01N33/544 , G01N33/566 , G01N33/58 , G01N30/72
Abstract: Analyzing samples injected into an inductively coupled plasma source can be improved by one or more of a stabilizing solution mixable with a sample prior to injection and a heated injector. The stabilizing solution can minimize the difference in osmotic pressure between the solution and the cells with a relatively low amount of dissolved solids (e.g., at or below about 0.2%). The stabilizing solution can contain a salt (e.g., ammonium nitrate) present in concentrations of at least 5 mM. The injector can be heated before and/or during injection. In some cases, heat from adjacent parts can be channeled into the injector to improve heating of the injector. An injector heated to sufficient temperatures can minimize solute buildup and can extend the usable time between cleanings. These improvements can be especially useful in elemental analysis, such as inductively coupled plasma mass spectrometry or inductively coupled plasma optical emission spectrometry.
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公开(公告)号：WO2022060624A1
公开(公告)日：2022-03-24
申请号：PCT/US2021/049667
申请日：2021-09-09
Applicant: FLUIDIGM CANADA INC.
Inventor： LOBODA, Alexander , JONG, Raymond , SULLIVAN, Michael , VOROBIEV, Serguei , ROTENBERG, Robert , STRATULATIV, Emil , VORONOV, Maxim , ARMSTRONG, Mark
Abstract: Inductively coupled plasma (ICP) analyzers use an ICP torch to generate a plasma in which a sample is atomized an ionized. Analysis of the atomic ions can be performed by atomic analysis, such as mass spectrometry (MS) or atomic emission spectrometry (AES). Particle based ICP analysis includes analysis of particles such as cells, beads, or laser ablation plumes, by atomizing and ionizing particles in an ICP torch followed by atomic analysis. In mass cytometry, mass tags of particles are analyzed by mass spectrometry, such as by ICP-MS. Systems and methods of the subject application include one or more of: a demountable ICP torch holder assembly, an external ignition device; an ICP load coil comprising an annular fin, particle suspension sample introduction fluidics, and ICP analyzers thereof.
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公开(公告)号：EP4215025A1
公开(公告)日：2023-07-26
申请号：EP21870009.4
申请日：2021-09-09
Applicant: Fluidigm Canada Inc.
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公开(公告)号：EP3775891A1
公开(公告)日：2021-02-17
申请号：EP19784699.1
申请日：2019-04-12
Applicant: Fluidigm Canada Inc.
Inventor： BARANOV, Vladimir , LOBODA, Alexander , SULLIVAN, Michael
IPC: G01N33/50 , G01N33/532 , G01N33/543 , G01N33/544 , G01N33/566 , G01N33/58 , G01N30/72
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