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    STABILIZED CELL ACQUISITION FOR ELEMENTAL ANALYSIS
    2.
    发明申请
    STABILIZED CELL ACQUISITION FOR ELEMENTAL ANALYSIS 审中-公开

    公开(公告)号：WO2019200307A1

    公开(公告)日：2019-10-17

    申请号：PCT/US2019/027306

    申请日：2019-04-12

    Applicant: FLUIDIGM CANADA INC. ,  FLUIDIGM CORPORATION

    Inventor： BARANOV, Vladimir ,  LOBODA, Alexander ,  SULLIVAN, Michael

    IPC: G01N33/50 ,  G01N33/532 ,  G01N33/543 ,  G01N33/544 ,  G01N33/566 ,  G01N33/58 ,  G01N30/72

    Abstract: Analyzing samples injected into an inductively coupled plasma source can be improved by one or more of a stabilizing solution mixable with a sample prior to injection and a heated injector. The stabilizing solution can minimize the difference in osmotic pressure between the solution and the cells with a relatively low amount of dissolved solids (e.g., at or below about 0.2%). The stabilizing solution can contain a salt (e.g., ammonium nitrate) present in concentrations of at least 5 mM. The injector can be heated before and/or during injection. In some cases, heat from adjacent parts can be channeled into the injector to improve heating of the injector. An injector heated to sufficient temperatures can minimize solute buildup and can extend the usable time between cleanings. These improvements can be especially useful in elemental analysis, such as inductively coupled plasma mass spectrometry or inductively coupled plasma optical emission spectrometry.

    MOLECULAR CYTOMETRY
    4.
    发明申请
    MOLECULAR CYTOMETRY 审中-公开
    分子细胞计数

    公开(公告)号：WO2014190429A1

    公开(公告)日：2014-12-04

    申请号：PCT/CA2014/050474

    申请日：2014-05-22

    Applicant: FLUIDIGM CANADA INC.

    Inventor： BANDURA, Dmitry ,  BARANOV, Vladimir ,  LOBODA, Alexander ,  ORNATSKY, Olga ,  TANNER, Scott

    IPC: G01N27/62 ,  G01N33/483

    CPC classification number: G01N33/54366 ,  G01N15/1031 ,  G01N15/1404 ,  G01N15/1459 ,  G01N27/622 ,  G01N27/624 ,  G01N33/483 ,  G01N33/532 ,  G01N33/54313 ,  G01N2015/1006 ,  G01N2458/15

    Abstract: The invention relates to methods and devices for molecular cytometry. The molecular cytometer is for use in the analysis of molecular tag labeled particles. In the molecular cytometer, volatile molecular tags attached to the particles, such as cells, are released as groups of molecular tags and ionized by the method of soft ionization to produce corresponding groups of molecular ions. The molecular cytometer has two detectors, one to detect the presence of the groups of molecular ions and the other to detect mobility separated molecular ions. The mobility separated molecular ions are synchronized to correspond with the groups of molecular ions.

    Abstract translation: 本发明涉及用于分子细胞计数的方法和装置。 分子光谱仪用于分子标签标记颗粒的分析。 在分子细胞仪中，附着于粒子（如细胞）的挥发性分子标记作为分子标签的基团释放，并通过软电离方法离子化以产生相应的分子离子组。 分子细胞仪有两个检测器，一个用于检测分子离子组的存在，另一个用于检测迁移率分离的分子离子。 迁移率分离的分子离子被同步以对应于分子离子的组。

    LASER ENABLED IMAGING MASS CYTOMETRY
    5.
    发明申请
    LASER ENABLED IMAGING MASS CYTOMETRY 审中-公开
    激光启动成像大量细胞计数

    公开(公告)号：WO2016126988A1

    公开(公告)日：2016-08-11

    申请号：PCT/US2016/016637

    申请日：2016-02-04

    Applicant: FLUIDIGM CANADA INC.

    Inventor： LOBODA, Alexander V. ,  BARANOV, Vladimir

    IPC: G01N33/53

    CPC classification number: H01J49/105 ,  G01N15/10 ,  G01N33/4833 ,  G01N2015/0065 ,  G01N2015/1006 ,  H01J49/0459 ,  H01J49/0463

    Abstract: The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry.

    Abstract translation: 本发明涉及使用激光烧蚀电感耦合等离子体质谱（LA-ICP-MS）分析样品的方法和装置。 本发明提供方法和装置，其中个体消融羽流被明显地捕获并转移到ICP，随后通过质谱法分析。

    ADDITIONAL MASS TAG POLYMERS FOR MASS CYTOMETRY
    6.
    发明申请
    ADDITIONAL MASS TAG POLYMERS FOR MASS CYTOMETRY 审中-公开

    公开(公告)号：WO2021026483A1

    公开(公告)日：2021-02-11

    申请号：PCT/US2020/045470

    申请日：2020-08-07

    Applicant: FLUIDIGM CANADA INC.

    Inventor： LIU, Peng ,  MAJONIS, Daniel ,  BARANOV, Vladimir

    IPC: A61K51/04 ,  A61K51/00 ,  A61K51/02

    Abstract: A new class of mass-tag polymers is provided, which include enriched metal isotopes such as zirconium and hafnium mass tags. The chemistry of these new mass tags are different from that of lanthanide mass tags, and opens up new mass channels that can be used in mass cytometry. These polymers may be used for mass cytometry, therapeutic delivery of a radioactive isotope, or screening of a therapeutic isotope. Aspects include a kit, method of making, and method of using a polymer, isotopic composition, or both. A kit may include a polymer. The polymer may include pendant groups that chelate an enriched isotope, such as zirconium and/or hafnium. The kit may include an isotopic composition comprising an enriched zirconium or hafnium isotope. Polymers may be conjugated to a biologically active material. Aspects may also include making a kit. Aspects include use of a kit, such as for mass cytometry.

    METHODS AND SYSTEMS FOR CORRELATING RESULTS OF OPTICAL AND MASS CYTOMETRY
    7.
    发明申请
    METHODS AND SYSTEMS FOR CORRELATING RESULTS OF OPTICAL AND MASS CYTOMETRY 审中-公开
    用于相关光学和质谱测定结果的方法和系统

    公开(公告)号：WO2016105418A1

    公开(公告)日：2016-06-30

    申请号：PCT/US2014/072377

    申请日：2014-12-24

    Applicant: FLUIDIGM CANADA INC.

    Inventor： BARANOV, Vladimir

    IPC: G01N15/10

    CPC classification number: G01N15/1031 ,  G01N15/1427 ,  G01N15/1429 ,  G01N15/1459 ,  G01N27/622 ,  G01N2015/1006 ,  G01N2015/1043 ,  G01N2015/1477

    Abstract: This disclosure is directed to systems and methods that enable optical-based cytometric techniques and mass cytometric techniques to be used in the investigation of the same set of particles. The systems and methods include an optical analysis system that individually receives one or more particles of a sample of particles. The optical analysis system generates optical particle data for each optically detectable particle of the sample that passes through the optical analysis system. A mass cytometry system also receives each particle that passes through the optical analysis system and generates mass particle data for each detectable particle that enters the mass cytometry system. The methods and systems correlate the optical particle data and the mass particle data associated with the same particles.

    Abstract translation: 本公开涉及使得基于光学的细胞计算技术和质谱技术可用于研究相同组的颗粒的系统和方法。 该系统和方法包括单独接收一个或多个颗粒样品颗粒的光学分析系统。 光学分析系统为通过光学分析系统的样品的每个可光学检测的颗粒产生光学粒子数据。 质量细胞计量系统还接收通过光学分析系统的每个颗粒，并为进入质谱仪系统的每个可检测的颗粒产生质量粒子数据。 方法和系统将光学粒子数据和与相同粒子相关联的质量粒子数据相关联。

    CELL ANALYSIS BY MASS CYTOMETRY
    9.
    发明申请
    CELL ANALYSIS BY MASS CYTOMETRY 审中-公开
    细胞分析通过细胞计数

    公开(公告)号：WO2014063247A1

    公开(公告)日：2014-05-01

    申请号：PCT/CA2013/050798

    申请日：2013-10-22

    Applicant: FLUIDIGM CANADA INC.

    Inventor： BARANOV, Vladimir

    IPC: G01N15/10 ,  C12M1/34 ,  C12Q1/00 ,  C40B20/02 ,  C40B20/04 ,  H01J49/40

    CPC classification number: G01N15/10 ,  C12M1/343 ,  G01N1/04 ,  G01N33/4833 ,  G01N33/569 ,  G01N2001/045 ,  G01N2015/1006 ,  G01N2015/1093

    Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.

    Abstract translation: 相互排斥的基于细胞的分析技术的组合可以应用于同一组细胞用于分析。 可以通过用针对质粒细胞分析的候选细胞产生的每种技术来制备相同组的细胞用于分析。 该配置允许每个技术之间的信息的相关性，以产生具有相同组的单元的蜂窝信息的多维矩阵。

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