公开(公告)号：WO2017186793A1

公开(公告)日：2017-11-02

申请号：PCT/EP2017/059930

申请日：2017-04-26

Applicant: FORSCHUNGSVERBUND BERLIN E.V.

Inventor： KRAUSE, Gerd ,  HOYER, Inna ,  SPECKER, Edgar ,  FURKERT, Jens ,  MARCINKOWSKI, Patrick ,  VON KRIES, Jens-Peter ,  NEUENSCHWANDER, Martin ,  NAZARE, Marc

IPC: A61K31/429 ,  A61K31/495 ,  A61P5/14 ,  A61P35/00

Abstract: The invention relates to chemical compounds that are useful in the treatment of a subject afflicted by a thyroid disease, in particular to compounds that exhibit activity as thyroid-stimulating hormone receptor (TSHR) antagonists and their use in the treatment of hyperthyroidism, Graves' disease, Graves' Ophthalmopathy and thyroid cancer.

Abstract translation: 本发明涉及用于治疗患有甲状腺疾病的受试者的化合物，特别是涉及表现出作为促甲状腺激素受体（TSHR）拮抗剂的活性的化合物及其在 甲状腺功能亢进症，格雷夫斯病，格雷夫斯眼病和甲状腺癌的治疗。

公开(公告)号：EP3448381A1

公开(公告)日：2019-03-06

申请号：EP17720091.2

申请日：2017-04-26

Applicant: Forschungsverbund Berlin E.V.

Inventor： KRAUSE, Gerd ,  HOYER, Inna ,  SPECKER, Edgar ,  FURKERT, Jens ,  MARCINKOWSKI, Patrick ,  VON KRIES, Jens-Peter ,  NEUENSCHWANDER, Martin ,  NAZARE, Marc

IPC: A61K31/429 ,  A61K31/495 ,  A61P5/14 ,  A61P35/00