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公开(公告)号：WO2017186793A1
公开(公告)日：2017-11-02
申请号：PCT/EP2017/059930
申请日：2017-04-26
Applicant: FORSCHUNGSVERBUND BERLIN E.V.
Inventor： KRAUSE, Gerd , HOYER, Inna , SPECKER, Edgar , FURKERT, Jens , MARCINKOWSKI, Patrick , VON KRIES, Jens-Peter , NEUENSCHWANDER, Martin , NAZARE, Marc
IPC: A61K31/429 , A61K31/495 , A61P5/14 , A61P35/00
Abstract: The invention relates to chemical compounds that are useful in the treatment of a subject afflicted by a thyroid disease, in particular to compounds that exhibit activity as thyroid-stimulating hormone receptor (TSHR) antagonists and their use in the treatment of hyperthyroidism, Graves' disease, Graves' Ophthalmopathy and thyroid cancer.
Abstract translation: 本发明涉及用于治疗患有甲状腺疾病的受试者的化合物，特别是涉及表现出作为促甲状腺激素受体（TSHR）拮抗剂的活性的化合物及其在 甲状腺功能亢进症，格雷夫斯病，格雷夫斯眼病和甲状腺癌的治疗。
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公开(公告)号：WO2022043465A1
公开(公告)日：2022-03-03
申请号：PCT/EP2021/073663
申请日：2021-08-26
Applicant: MAX DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT , CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN , FORSCHUNGSVERBUND BERLIN E.V.
Inventor： KETTENMANN, Helmut , WOLF, Susanne , JORDAN, Philipp , KLEISSLE, Sabrina , NEUENSCHWANDER, Martin , SPECKER, Edgar , NAZARE, Marc
Abstract: The invention relates to compounds useful as inhibitors of NO production, especially inhibitors of the inducible NO synthase iNOS expressed by microglia and macrophages. The invention also relates to pharmaceutical compositions comprising these compounds and to therapeutic uses of these compounds, especially in the prophylaxis or treatment of conditions characterized by excess NO production, such as ischemic stroke and retinopathies.
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公开(公告)号：EP3448381A1
公开(公告)日：2019-03-06
申请号：EP17720091.2
申请日：2017-04-26
Applicant: Forschungsverbund Berlin E.V.
Inventor： KRAUSE, Gerd , HOYER, Inna , SPECKER, Edgar , FURKERT, Jens , MARCINKOWSKI, Patrick , VON KRIES, Jens-Peter , NEUENSCHWANDER, Martin , NAZARE, Marc
IPC: A61K31/429 , A61K31/495 , A61P5/14 , A61P35/00
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