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公开(公告)号：WO2017186793A1
公开(公告)日：2017-11-02
申请号：PCT/EP2017/059930
申请日：2017-04-26
Applicant: FORSCHUNGSVERBUND BERLIN E.V.
Inventor： KRAUSE, Gerd , HOYER, Inna , SPECKER, Edgar , FURKERT, Jens , MARCINKOWSKI, Patrick , VON KRIES, Jens-Peter , NEUENSCHWANDER, Martin , NAZARE, Marc
IPC: A61K31/429 , A61K31/495 , A61P5/14 , A61P35/00
Abstract: The invention relates to chemical compounds that are useful in the treatment of a subject afflicted by a thyroid disease, in particular to compounds that exhibit activity as thyroid-stimulating hormone receptor (TSHR) antagonists and their use in the treatment of hyperthyroidism, Graves' disease, Graves' Ophthalmopathy and thyroid cancer.
Abstract translation: 本发明涉及用于治疗患有甲状腺疾病的受试者的化合物，特别是涉及表现出作为促甲状腺激素受体（TSHR）拮抗剂的活性的化合物及其在 甲状腺功能亢进症，格雷夫斯病，格雷夫斯眼病和甲状腺癌的治疗。
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公开(公告)号：WO2021028346A1
公开(公告)日：2021-02-18
申请号：PCT/EP2020/072275
申请日：2020-08-07
Applicant: FORSCHUNGSVERBUND BERLIN E.V.
Inventor： KRAUSE, Gerd , MARCINKOWSKI, Patrick
Abstract: The invention relates to one or more regions of the thyroid-stimulating hormone receptor (TSHR), identified herein as a TSHR ligand binding domain. Such a domain is considered a binding pocket for chemical compounds, for example S37 or derivatives thereof, that exhibit activity as thyroid-stimulating hormone receptor (TSHR) antagonists. Embodiments of the invention relate to proteins and corresponding coding nucleic acids for the proteins of the invention, for example the TSHR ligand binding domain and related proteins. The invention relates to methods of screening for or testing compounds that interact, bind and/or modify the TSHR ligand binding domain of the invention.
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公开(公告)号：EP3448381A1
公开(公告)日：2019-03-06
申请号：EP17720091.2
申请日：2017-04-26
Applicant: Forschungsverbund Berlin E.V.
Inventor： KRAUSE, Gerd , HOYER, Inna , SPECKER, Edgar , FURKERT, Jens , MARCINKOWSKI, Patrick , VON KRIES, Jens-Peter , NEUENSCHWANDER, Martin , NAZARE, Marc
IPC: A61K31/429 , A61K31/495 , A61P5/14 , A61P35/00
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