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    IMIDAZOLE COMPOUND AND LIPOSOME CONTAINING SAME
    2.
    发明公开
    IMIDAZOLE COMPOUND AND LIPOSOME CONTAINING SAME 审中-公开
    IMIDAZOLVERBINDUNG UND LIPOSOM DAMIT

    公开(公告)号：EP3170812A4

    公开(公告)日：2017-06-14

    申请号：EP15822145

    申请日：2015-07-16

    Applicant: FUJIFILM CORP

    Inventor： OYA TOYOHISA ,  ISHIYAMA AYUMI ,  NISHIKAWA NAOYUKI

    IPC: C07D233/64 ,  A61K9/127 ,  A61K31/713 ,  A61K47/22 ,  C12N15/113

    CPC classification number: A61K9/1272 ,  A61K9/127 ,  A61K31/713 ,  A61K47/22 ,  C07D233/64 ,  C12N15/113

    Abstract: Provided are a novel imidazole compound which has a high stability of the compound itself; and a novel imidazole compound which is useful as a membrane-constituting lipid of liposomes. Disclosed are a compound represented by the following General Formula (1), and a liposome containing the same compound. In the formula, Z is an imidazolyl group which may be substituted, L 1 is an alkylene group having 1 to 4 carbon atoms which may be substituted, X is an oxygen atom or a nitrogen-containing substituent, n is an integer of 2 to 4, m is an integer of 1 to 20, L 2 is a divalent linking group having 1 to 6 carbon atoms, Y is a nitrogen-containing group, R 1 and R 2 are a hydrogen group or an alkyl group having 1 to 6 carbon atoms, R 3 is a hydrogen atom or a substituent, and R 4 and R 5 are an alkyl group having 1 to 40 carbon atoms.

    Abstract translation: 提供了一种新型咪唑化合物，该化合物本身具有高稳定性; 以及可用作脂质体的膜构成脂质的新型咪唑化合物。 公开了下述通式（1）所示的化合物和含有该化合物的脂质体。 式中，Z表示可以被取代的咪唑基，L 1表示可以被取代的碳原子数1〜4的亚烷基，X表示氧原子或含氮取代基，n表示2〜 4，m为1至20的整数，L 2为具有1至6个碳原子的二价连接基团，Y为含氮基团，R 1和R 2为氢基或具有1至6个碳原子的烷基 碳原子，R 3是氢原子或取代基，R 4和R 5是具有1-40个碳原子的烷基。

    METHOD FOR PRODUCING LIPID PARTICLE AND NUCLEIC ACID DELIVERY CARRIER COMPRISING LIPID PARTICLE
    7.
    发明公开
    METHOD FOR PRODUCING LIPID PARTICLE AND NUCLEIC ACID DELIVERY CARRIER COMPRISING LIPID PARTICLE 有权
    VERFAHREN ZUR HERSTELLUNG EINES LIPIDPARTIKELS UNDNUKLEINSÄUREFREISETZUNGSTRÄGERMIT LIPIDPARTIKEL

    公开(公告)号：EP3170504A4

    公开(公告)日：2017-07-26

    申请号：EP15822112

    申请日：2015-07-16

    Applicant: FUJIFILM CORP

    Inventor： NISHIKAWA NAOYUKI ,  SUGIYAMA SUSUMU ,  SEKIGUCHI TAKAHIRO ,  ONO MAKOTO

    IPC: A61K31/7088 ,  A61K9/10 ,  A61K31/713 ,  A61K47/22 ,  A61K47/24 ,  A61K48/00

    CPC classification number: C12N15/113 ,  A61K9/10 ,  A61K9/107 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/22 ,  A61K47/24 ,  A61K48/00 ,  C12N2310/14 ,  C12N2320/32

    Abstract: An object of the present invention is to provide a method for producing lipid particles which can hold nucleic acids or the like at a high inclusion rate, and a nucleic acid delivery carrier having the lipid particles. According to the present invention, there is provided a method for producing lipid particles including nucleic acids, the method including the following steps of (1) to (4): (1) a step of heating an oil phase containing a phospholipid, an alcohol, and an ester; (2) a step of mixing an oil phase prepared in step (1) with a water phase containing nucleic acids; (3) a step of cooling the mixed liquid which contains the oil phase and the water phase and has been obtained in step (2), and crystallizing lipid particles; and (4) a step of removing the alcohol and the ester from the mixed liquid which contains the oil phase and the water phase and has been obtained in step (3).

    Abstract translation: 本发明的目的在于提供能够以高包含率保持核酸等的脂质粒子的制造方法以及具有该脂质粒子的核酸运送用载体。 根据本发明，提供了一种用于生产包含核酸的脂质颗粒的方法，所述方法包括以下步骤（1）至（4）：（1）将含有磷脂，醇 ，和酯; （2）将步骤（1）中制备的油相与含有核酸的水相混合的步骤; （3）冷却步骤（2）中获得的包含油相和水相的混合液并使脂质颗粒结晶的步骤; （4）从步骤（3）中获得的包含油相和水相的混合液中除去醇和酯的步骤。

    Composition for producing biaxial optical anisotropic film
    10.
    发明专利
    Composition for producing biaxial optical anisotropic film 审中-公开
    用于生产双色光学异相薄膜的组合物

    公开(公告)号：JP2011008207A

    公开(公告)日：2011-01-13

    申请号：JP2009166692

    申请日：2009-07-15

    Applicant: Fujifilm Corp ,  富士フイルム株式会社

    Inventor： KIMURA MASAOMI ,  WATABE HIDETOSHI ,  NISHIKAWA NAOYUKI ,  MIZUMURA MASATOSHI

    IPC: G02B5/30 ,  C09K19/38 ,  C09K19/54 ,  G02F1/1335 ,  G02F1/13363

    Abstract: PROBLEM TO BE SOLVED: To provide a composition that easily produces an optical anisotropic film having improved heat resistance, which is useful for optical compensation of a liquid crystal display device.SOLUTION: The composition for producing a biaxial optical anisotropic film having a deformed twisted helical structure contains a polymerizable liquid crystal compound and a polymerization initiator containing an oxime ester compound. A method for producing an optical anisotropic film includes applying the liquid crystal composition on a support, subjecting the liquid crystal composition to cholesteric alignment, and irradiating the liquid crystal composition with polarized light, but not includes irradiating the composition with non-polarized light before irradiating the composition with polarized light.

    Abstract translation: 要解决的问题：提供一种易于产生具有改善的耐热性的光学各向异性膜的组合物，其可用于液晶显示装置的光学补偿。解决方案：用于制造具有变形扭曲螺旋的双轴向光学各向异性膜的组合物 结构含有可聚合液晶化合物和含有肟酯化合物的聚合引发剂。 一种光学各向异性膜的制造方法，其特征在于，将液晶组合物涂布在载体上，使液晶组合物进行胆甾醇的取向，并对该液晶组合物进行偏振光照射，但不包括在照射前以非偏振光照射组合物 具有偏振光的组成。

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