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    METHOD FOR PRODUCING LIPID PARTICLE AND NUCLEIC ACID DELIVERY CARRIER COMPRISING LIPID PARTICLE
    6.
    发明公开
    METHOD FOR PRODUCING LIPID PARTICLE AND NUCLEIC ACID DELIVERY CARRIER COMPRISING LIPID PARTICLE 有权
    VERFAHREN ZUR HERSTELLUNG EINES LIPIDPARTIKELS UNDNUKLEINSÄUREFREISETZUNGSTRÄGERMIT LIPIDPARTIKEL

    公开(公告)号：EP3170504A4

    公开(公告)日：2017-07-26

    申请号：EP15822112

    申请日：2015-07-16

    Applicant: FUJIFILM CORP

    Inventor： NISHIKAWA NAOYUKI ,  SUGIYAMA SUSUMU ,  SEKIGUCHI TAKAHIRO ,  ONO MAKOTO

    IPC: A61K31/7088 ,  A61K9/10 ,  A61K31/713 ,  A61K47/22 ,  A61K47/24 ,  A61K48/00

    CPC classification number: C12N15/113 ,  A61K9/10 ,  A61K9/107 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/22 ,  A61K47/24 ,  A61K48/00 ,  C12N2310/14 ,  C12N2320/32

    Abstract: An object of the present invention is to provide a method for producing lipid particles which can hold nucleic acids or the like at a high inclusion rate, and a nucleic acid delivery carrier having the lipid particles. According to the present invention, there is provided a method for producing lipid particles including nucleic acids, the method including the following steps of (1) to (4): (1) a step of heating an oil phase containing a phospholipid, an alcohol, and an ester; (2) a step of mixing an oil phase prepared in step (1) with a water phase containing nucleic acids; (3) a step of cooling the mixed liquid which contains the oil phase and the water phase and has been obtained in step (2), and crystallizing lipid particles; and (4) a step of removing the alcohol and the ester from the mixed liquid which contains the oil phase and the water phase and has been obtained in step (3).

    Abstract translation: 本发明的目的在于提供能够以高包含率保持核酸等的脂质粒子的制造方法以及具有该脂质粒子的核酸运送用载体。 根据本发明，提供了一种用于生产包含核酸的脂质颗粒的方法，所述方法包括以下步骤（1）至（4）：（1）将含有磷脂，醇 ，和酯; （2）将步骤（1）中制备的油相与含有核酸的水相混合的步骤; （3）冷却步骤（2）中获得的包含油相和水相的混合液并使脂质颗粒结晶的步骤; （4）从步骤（3）中获得的包含油相和水相的混合液中除去醇和酯的步骤。

    Optical compensation film, its manufacturing method, polarizing plate, and liquid crystal display device
    8.
    发明专利
    Optical compensation film, its manufacturing method, polarizing plate, and liquid crystal display device 审中-公开
    光学补偿膜，其制造方法，极化板和液晶显示装置

    公开(公告)号：JP2008052267A

    公开(公告)日：2008-03-06

    申请号：JP2007192536

    申请日：2007-07-24

    Applicant: Fujifilm Corp ,  富士フイルム株式会社

    Inventor： KUMON YOSHIAKI ,  YOSHIKANE MITSUO ,  HARUTA HIROMUNE ,  SUGIYAMA SUSUMU ,  KAMIHIRA SHIGEO ,  FUKAGAWA NOBUTAKA ,  NAKAMURA KAZUHIRO

    IPC: G02B5/30 ,  B29C41/28 ,  B29C55/02 ,  B29L7/00 ,  B29L11/00 ,  G02F1/1335 ,  G02F1/13363

    Abstract: PROBLEM TO BE SOLVED: To provide a liquid crystal display device, particularly the liquid crystal display devices of VA, IPS and OCB modes capable of reducing coloring in a viewing angle direction by precisely performing optical compensation not only in the front direction but also in oblique directions. SOLUTION: The optical compensation film or the like includes a transparent support containing at least one kind of Rth raising agent. In the transparent support, the degree of orientation P defined by an expression (A), P= 2 β-1>/2, calculated by x-ray diffraction measurement is within 0.05 to 0.30, where 2 β>=∫(0, π)cos 2 βI(β)sinβdβ/∫(0, π)I(β)sinβdβ is satisfied. In the expression, β is an angle defined by an incident plane of the incident X-ray and one direction in a surface of the transparent support, and I is diffraction intensity at 2θ=8° in an X-ray diffraction chart measured at the angle β. COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 解决问题：提供一种液晶显示装置，特别是能够通过精确地进行光学补偿而不仅在正面方向上而是在视野方向上减少着色的VA，IPS和OCB模式的液晶显示装置，而且 也在斜方向。 解决方案：光学补偿膜等包括含有至少一种Rth引发剂的透明支撑体。 在透明支持体中，通过X射线衍射测定计算出的表达式（A）定义的取向度P为<= 0.03os 2 β-1> / 2为0.05〜0.30， 其中 2 β> =∫（0，π）cos 2 βI（β）sinβdβ/∫（0，π）I（β）sinβdβ。 在该表达式中，β是由入射X射线的入射面和透明支撑体的表面的一个方向所限定的角度，I是在X射线衍射图中测定的X射线衍射图中的2θ= 8°处的衍射强度 角β。 版权所有（C）2008，JPO＆INPIT

    Cellulose acylate film, polarizing plate, and liquid crystal display device
    9.
    发明专利
    Cellulose acylate film, polarizing plate, and liquid crystal display device 有权
    纤维素聚酯薄膜，偏光板和液晶显示装置

    公开(公告)号：JP2007268956A

    公开(公告)日：2007-10-18

    申请号：JP2006100169

    申请日：2006-03-31

    Applicant: Fujifilm Corp ,  富士フイルム株式会社

    Inventor： SUGIYAMA SUSUMU

    IPC: B29C55/02 ,  B29K1/00 ,  B29L7/00 ,  C08J5/18 ,  G02B5/30

    CPC classification number: C08J5/18 ,  C08J2301/10 ,  G02B5/30 ,  G02B5/3083 ,  G02F1/133528 ,  Y10T428/10 ,  Y10T428/1041 ,  Y10T428/105

    Abstract: PROBLEM TO BE SOLVED: To provide a cellulose acylate film which is excellent in developabilities of retardation in the front and film thickness direction, thin and has an easy handleability in producing and machining, and a liquid crystal display device using the cellulose acylate film and having a small change in characteristics of viewing angle, and a polarizing plate used in the liquid crystal device. SOLUTION: The cellulose acylate film is characterized in that the film thickness is 20 to 70 μm, and in that the modulus of elasticity in at least one direction of the film following direction and width direction is 3.5 to 10 GPa. COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 待解决的问题：提供一种纤维素酰化物膜，其在前和膜厚度方向上的延迟的显影性优异，并且在制造和机械加工中具有易于操作的性能，以及使用纤维素酰化物的液晶显示装置 并且具有视角特性的小变化，以及在液晶装置中使用的偏光板。 解决方案：酰化纤维素膜的特征在于膜厚度为20至70μm，并且沿着膜方向和宽度方向的膜的至少一个方向上的弹性模量为3.5至10GPa。 版权所有（C）2008，JPO＆INPIT

    Optical film, manufacturing method of optical film, and polarizing plate, liquid crystal display device using optical film
    10.
    发明专利
    Optical film, manufacturing method of optical film, and polarizing plate, liquid crystal display device using optical film 审中-公开
    光学膜，光学膜的制造方法和偏光板，使用光学膜的液晶显示装置

    公开(公告)号：JP2007264110A

    公开(公告)日：2007-10-11

    申请号：JP2006086300

    申请日：2006-03-27

    Applicant: Fujifilm Corp ,  富士フイルム株式会社

    Inventor： SUGIYAMA SUSUMU ,  TOYAMA HIROSHI

    IPC: G02B5/30 ,  B29C55/02 ,  B29L7/00 ,  B29L11/00 ,  G02F1/1335 ,  G02F1/13357

    Abstract: PROBLEM TO BE SOLVED: To provide an optical film especially for VA, IPS and OCB modes which can be easily teared in a TD direction, accurately and optically compensates a liquid crystal cell and improves high contrast and a color shift depending on a visual angle direction of black display, to provide a manufacturing method of the same and to provide a polarizing plate using the optical film. SOLUTION: The optical film is characterized in that a value obtained by dividing a smaller value of values of breaking elongation in a longer side direction of the film and breaking elongation in a direction nearly orthogonal to the longer side direction by the other value is 0.01 to 0.28, or a value obtained by dividing a larger value of values of breaking strength in the longer side direction of the film and breaking strength in the direction nearly orthogonal to the longer side direction by the other value is 1.3 to 10.0. COPYRIGHT: (C)2008,JPO&INPIT

    Abstract translation: 要解决的问题：为了提供一种特别适用于可以在TD方向上容易地进行切割的VA，IPS和OCB模式的光学膜，可精确地和光学地补偿液晶单元并且改善高对比度和根据 黑色显示的视角方向，以提供其制造方法，并提供使用该光学膜的偏振片。 解决方案：光学膜的特征在于，通过将膜的长边方向上的断裂伸长值的值的值和与长边方向近似正交的方向的断裂伸长率除以另一个值而获得的值 为0.01〜0.28，或者通过将膜的长边方向的断裂强度值的大值和与长边方向近似正交的方向的断裂强度除以另一个值而得到的值为1.3〜10.0。 版权所有（C）2008，JPO＆INPIT

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