公开(公告)号：KR840002294B1

公开(公告)日：1984-12-15

申请号：KR810002646

申请日：1981-07-21

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： IMANAKA HIROSHI ,  MIYOSHI TOSHIO ,  KONOMI TOSHIO ,  KUBOCHI YOSHIAKI ,  HATTORI SEIZIRO ,  KAWAKITA TAKESHI

IPC: C12N9/18 ,  C12P35/06 ,  C12P39/00 ,  C12R1/645 ,  C12R1/745

公开(公告)号：US3923790A

公开(公告)日：1975-12-02

申请号：US46338274

申请日：1974-04-23

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： IMANAKA HIROSHI ,  KAMIYA TAKASHI ,  MAENO SHIZUO ,  MIYOSHI TOSHIO ,  MIYAIRI NORIMASA ,  AOKI HATSUO ,  KOHSAKA MASANOBU ,  KOMORI TADAAKI ,  SAKAI HEIICHI

IPC: A61K35/74 ,  C07D498/08 ,  C07H9/06 ,  C12P1/06 ,  C12R1/465

CPC classification number: C07D498/08 ,  C07H9/06 ,  Y10S435/886

Abstract: An antibiotic WS-4545 and the acyl derivatives thereof, which are active against a pathogenic bacteria and useful as an effective antimicrobial agent in treatment of infectious diseases caused by bacteria, the antibiotic WS-4545 being produced by fermentation of Streptomyces sapporonensis ATCC 21532 and its mutants in a nutrient medium and the acyl derivatives of said antibiotic being prepared by acylating said antibiotic with an acylating agent.

Abstract translation: 抗生素WS-4545及其酰基衍生物，其对病原菌具有活性并且可用作治疗由细菌引起的感染性疾病的有效抗微生物剂，抗生素WS-4545是通过发酵链霉菌（Streptomyces sapporonensis）ATCC 21532及其 营养培养基中的突变体和所述抗生素的酰基衍生物通过用酰化剂酰化所述抗生素来制备。

公开(公告)号：JPH0249580A

公开(公告)日：1990-02-19

申请号：JP8085989

申请日：1989-03-30

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： IMANAKA HIROSHI ,  MIYOSHI TOSHIO ,  MOTOI SATOO ,  KUBOCHI YOSHIAKI ,  HATTORI SEIJIRO ,  KAWAKITA TAKESHI

IPC: C12N9/18 ,  C12P35/06 ,  C12P39/00 ,  C12R1/645 ,  C12R1/745

Abstract: NEW MATERIAL:Acetyl esterase 4466-I and 4466-II having the following properties. Hydrolysis activity of cephalosporin C to deacetylcephalosporin C, positive; substrate specificity, hydrolyzable substrate is acetic acid ester; optimum pH, , Mn , Zn , Ni , Ca , Ba and Fe ; Km value, 11.5mM for 4466-I and 13.7mM for 4466-II; molecular weight (gel-permeation), 780,000 Dalton for 4466-I and 920,000 Dalton for 4466-II. USE:The enzyme deacetylates cephalosporin C to give deacetylcephalosporin C useful as a medicine in remarkably high yield. PREPARATION:The objective enzyme can be produced, e.g., by culturing Aureobasidium pullulans IFO 4466 at 25 deg.C and pH5-8 for 24-50hr under aeration and agitation.

公开(公告)号：IT1059509B

公开(公告)日：1982-06-21

申请号：IT1984374

申请日：1974-01-25

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： SAKAI HEIICHI ,  MIYOSHI TOSHIO ,  MIYAIRI MORIMASA ,  AOKI HATSUO ,  KOHSAKA MASANOBU ,  IMANAKA HIROSHI

IPC: C12P1/06 ,  C07G11/00 ,  C12P17/18 ,  C12R1/465 ,  C12P

Abstract: A process for the production of biciclomycin which consists in cultivating a variety of streptomycesgriseoflavus var. Bicyclomyceticus in an aqueous nutrient medium containing a nitrogen and carbon source under submerged aerobic conditions, until a substantial antibiotic activity is communicated to said medium for production of biciclomycin and to recover the biciclomycin from the culture broth. (Machine-translation by Google Translate, not legally binding)

公开(公告)号：DE3170118D1

公开(公告)日：1985-05-30

申请号：DE3170118

申请日：1981-07-20

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： IMANAKA HIROSHI ,  MIYOSHI TOSHIO ,  KONOMI TOSHIO ,  KUBOCHI YOSHIAKI ,  HATTORI SEIZIRO ,  KAWAKITA TAKESHI

IPC: C12N9/18 ,  C12P35/06 ,  C12P39/00 ,  C12R1/645 ,  C12R1/745

Abstract: Deacetylcephalosporin C is prepared by contacting cephalosporin C with an acetylesterase produced by a strain belonging to the genus Auresbasideum or a mutant thereof. Deacetylcephalosporin C is known as a valuable intermediate in syntheses of therapeutically-useful cephalosporin compounds.

公开(公告)号：AT12950T

公开(公告)日：1985-05-15

申请号：AT81303313

申请日：1981-07-20

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： IMANAKA HIROSHI ,  MIYOSHI TOSHIO ,  KONOMI TOSHIO ,  KUBOCHI YOSHIAKI ,  HATTORI SEIZIRO ,  KAWAKITA TAKESHI

IPC: C12N9/18 ,  C12P35/06 ,  C12P39/00 ,  C12R1/645 ,  C12R1/745

Abstract: Deacetylcephalosporin C is prepared by contacting cephalosporin C with an acetylesterase produced by a strain belonging to the genus Auresbasideum or a mutant thereof. Deacetylcephalosporin C is known as a valuable intermediate in syntheses of therapeutically-useful cephalosporin compounds.

公开(公告)号：DK155739B

公开(公告)日：1989-05-08

申请号：DK385473

申请日：1973-07-11

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： MIYOSHI TOSHIO ,  MIYAIRI NORIMASA ,  AOKI HATSUO ,  KOHSAKA MASANOBU ,  KOMORI TADAAKI ,  SAKAI HEIICHI ,  IMANAKA HIROSHI ,  KAMIYA TAKASHI ,  MAENO SHIZUO

IPC: A61K35/74 ,  C07D498/08 ,  C07H9/06 ,  C12P1/06 ,  C12R1/465

公开(公告)号：CA996049A

公开(公告)日：1976-08-31

申请号：CA124976

申请日：1971-10-12

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： MIYOSHI TOSHIO ,  MIYAIRI NORIMASA ,  AOKI HATSUO ,  KOHSAKA MASANOBU ,  KOMORI TADAAKI ,  SAKAI HEIICHI ,  IMANAKA HIROSHI ,  MAENO SHIZUO ,  KAMIYA TAKASHI

IPC: A61K35/74 ,  C07D498/08 ,  C07H9/06 ,  C12P1/06 ,  C12R1/465

公开(公告)号：CA960167A

公开(公告)日：1974-12-31

申请号：CA54098

申请日：1969-06-11

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： MIYAIRI NORIMASA ,  KOHSAKA MASANOBU ,  MIYOSHI TOSHIO ,  IKUSHIMA KOICHI ,  IMANAKA HIROSHI

IPC: A23K1/18 ,  A23K20/195

公开(公告)号：DE1929355A1

公开(公告)日：1969-12-18

申请号：DE1929355

申请日：1969-06-10

Applicant: FUJISAWA PHARMACEUTICAL CO

Inventor： MIYAIRI NORIMASA ,  KOHSAKA MASANOBU ,  MIYOSHI TOSHIO ,  IKUSHIMA KOICHI

IPC: A23K1/18 ,  A23K20/195 ,  C12D9/14