公开(公告)号：EP1283214A4

公开(公告)日：2004-09-22

申请号：EP01922014

申请日：2001-04-23

Applicant: FUSO PHARMACEUTICAL IND

Inventor： WAKAMIYA NOBUTAKA ,  KESHI HIROYUKI ,  OHTANI KATSUKI ,  SAKAMOTO TAKASHI ,  KISHI YUICHIRO

IPC: C07K14/47 ,  C07K14/785 ,  C12N15/12 ,  A01K67/027 ,  C07K16/18 ,  C12P21/02 ,  G01N33/53

CPC classification number: C07K14/4726 ,  A01K2217/05 ,  C07K14/785

Abstract: Isolated collectin (CL-L2s) genes containing a base sequence represented by SEQ ID NO:1, 3, 5, 7, 9, 12, 36, 38 or 40 relating to novel collectins which are expected as exhibiting an antibacterial activity, an antiviral activity, etc. particularly in the human body; and isolated collectin proteins containing an amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 13, 37, 39 or 41 and derivatives and fragments thereof.

公开(公告)号：EP0725149A4

公开(公告)日：1999-08-18

申请号：EP95907490

申请日：1993-08-10

Applicant: FUSO PHARMACEUTICAL IND

Inventor： MATSUHISA AKIO ,  SHIBA KIYOTAKA ,  MIKAWA YOSHIKAZU ,  KISHI YUICHIRO

IPC: C12Q1/68 ,  G01N27/447 ,  G01N33/50 ,  G01N33/58 ,  C12Q1/28 ,  C12Q1/42

CPC classification number: C12Q1/6816 ,  C12Q1/6813

Abstract: A method of detecting a nucleic acid which comprises bringing a solid carrier suspected to carry or contain a nucleic acid into contact with a polyamine containing, bound thereto, a label capable of generating a detectable signal or a precursor thereof to thereby form a complex between a nucleic acid, if any, and the polyamine, removing the polyamine which has not formed any complex before or after the conversion of the precursor, if used, into the label, and detecting the label.

Abstract translation: 一种检测核酸的方法，其包括将怀疑携带或含有核酸的固体载体与含有与其结合的多胺接触能够产生可检测信号的标记或其前体的标记，从而在 核酸（如果有的话）和多胺，除去在前体转化之前或之后没有形成任何复合物的多胺（如果使用的话）到标签中，并检测标签。

公开(公告)号：DE60126602T2

公开(公告)日：2007-11-22

申请号：DE60126602

申请日：2001-04-23

Applicant: FUSO PHARMACEUTICAL IND

Inventor： WAKAMIYA NOBUTAKA ,  KESHI HIROYUKI ,  OHTANI KATSUKI ,  SAKAMOTO TAKASHI ,  KISHI YUICHIRO

IPC: C07K14/47 ,  A01K67/027 ,  C07K14/785 ,  C07K16/18 ,  C12N15/12 ,  C12P21/02 ,  G01N33/53

公开(公告)号：EP1518557A4

公开(公告)日：2008-12-03

申请号：EP03738567

申请日：2003-06-30

Applicant: FUSO PHARMACEUTICAL IND

Inventor： WAKAMIYA NOBUTAKA ,  OHTANI KATSUKI ,  SAKAMOTO TAKASHI ,  KESHI HIROYUKI ,  KISHI YUICHIRO

IPC: A61K38/17 ,  A61P31/18 ,  A61P37/04 ,  A61P43/00 ,  A61K38/16

CPC classification number: A61K38/1709

Abstract: It is intended to disclose an anti-HIV agent which contains as the active ingredient a mannose-binding protein (MBP) and efficaciously contributes to the treatment of patients infected with human immunodeficiency virus (HIV) and inhibits the progress of the disease. It is also intended to disclose a method of evaluating an anti-HIV activity exerted by the MBP which involves the step of culturing HIV-infected cells in the presence of the MBP.

公开(公告)号：EP0872180A4

公开(公告)日：2001-08-01

申请号：EP96929521

申请日：1996-09-04

Applicant: FUSO PHARMACEUTICAL IND

Inventor： NAKAZAWA TERUKI ,  ARAKI HIROMASA ,  KISHI YUICHIRO ,  SHINODA SANJI ,  YAMADA MORIYUKI ,  OHASHI KAZUTOMO

IPC: A01K67/02 ,  A01K67/027 ,  C12N5/02 ,  C12N5/073 ,  C12N5/00

CPC classification number: A01K67/027 ,  C12N5/0604 ,  C12N2500/32

Abstract: Object: to provide a medium composition for external fertilization, in particular, one to be used in the incubation of an ovum or an early embryo, i.e., a fertilized ovum or in the pretreatment of an ovum or sperms. Means for solution: a medium composition for external fertilization which comprises as the essential components L-phenylalanine, L-tryptophan, L-lysine, L-threonine, L-valine, L-methionine, L-isoleucine, L-leucine, L-proline, glycine, L-alanine, L-tyrosine, L-histidine, L-arginine, L-taurine, L-aspartic acid, L-serine, L-asparagine, L-glutamic acid, L-glutamine and L-cystine.

公开(公告)号：CA2406884C

公开(公告)日：2009-02-17

申请号：CA2406884

申请日：2001-04-23

Applicant: FUSO PHARMACEUTICAL IND

Inventor： WAKAMIYA NOBUTAKA ,  KESHI HIROYUKI ,  OHTANI KATSUKI ,  KISHI YUICHIRO ,  SAKAMOTO TAKASHI

IPC: C07K14/47 ,  C07K14/78 ,  C07K14/785 ,  C12N15/12

Abstract: Isolated collectin (CL-L2s) genes containing a base sequence represented by SEQ ID NO:1, 3, 5, 7, 9, 12, 36, 38 or 40 relating to novel collectins which are expected as exhibiting an antibacterial activity, an antiviral activity, etc. particularly in the human body; and isolated collectin proteins containing an amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 1 3, 37, 39 or 41 and derivatives and fragments thereof.

公开(公告)号：AT353913T

公开(公告)日：2007-03-15

申请号：AT01922014

申请日：2001-04-23

Applicant: FUSO PHARMACEUTICAL IND

Inventor： WAKAMIYA NOBUTAKA ,  KESHI HIROYUKI ,  OHTANI KATSUKI ,  SAKAMOTO TAKASHI ,  KISHI YUICHIRO

IPC: C07K14/47 ,  C07K14/785 ,  C12N15/12 ,  A01K67/027 ,  C07K16/18 ,  C12P21/02 ,  G01N33/53

公开(公告)号：DK0872180T3

公开(公告)日：2003-08-11

申请号：DK96929521

申请日：1996-09-04

Applicant: FUSO PHARMACEUTICAL IND

Inventor： NAKAZAWA TERUKI ,  ARAKI HIROMASA ,  KISHI YUICHIRO ,  SHINODA SANJI ,  YAMADA MORIYUKI ,  OHASHI KAZUTOMO

IPC: A01K67/02 ,  A01K67/027 ,  C12N5/02 ,  C12N5/073 ,  C12N5/00

Abstract: The present invention aims to provide a medium composition for in vitro fertilization, in particular, a composition usable in the culture of ova or early embryos which are fertilized eggs, the preparation or culture of sperm, and the pre-treatment of ova or sperm. The composition comprises, as its essential components, L-phenylalanine, L-tryptophan, L-lysine, L-threonine, L-valine, L-methionine, L-isoleucine, L-leucine, L-proline, glycine, L-alanine, L-tyrosine, L-histidine, L-arginine, L-taurine, L-aspartic acid, L-serine, L-asparagine, L-glutamic acid, L-glutamine and L-cystine, provided that at least a part of the L-cystine may be replaced by L-cysteine.

公开(公告)号：DE69331443T2

公开(公告)日：2002-09-05

申请号：DE69331443

申请日：1993-08-10

Applicant: FUSO PHARMACEUTICAL IND

Inventor： MATSUHISA AKIO ,  SHIBA KIYOTAKA ,  MIKAWA YOSHIKAZU ,  KISHI YUICHIRO

IPC: C12Q1/68 ,  C12Q1/6813 ,  C12Q1/6816 ,  G01N27/447 ,  G01N33/50 ,  G01N33/58 ,  C12Q1/28 ,  C12Q1/42

Abstract: A method of detecting a nucleic acid which comprises bringing a solid carrier suspected to carry or contain a nucleic acid into contact with a polyamine containing, bound thereto, a label capable of generating a detectable signal or a precursor thereof to thereby form a complex between a nucleic acid, if any, and the polyamine, removing the polyamine which has not formed any complex before or after the conversion of the precursor, if used, into the label, and detecting the label.

公开(公告)号：DK0725149T3

公开(公告)日：2002-02-18

申请号：DK95907490

申请日：1993-08-10

Applicant: FUSO PHARMACEUTICAL IND

Inventor： MATSUHISA AKIO ,  SHIBA KIYOTAKA ,  MIKAWA YOSHIKAZU ,  KISHI YUICHIRO

IPC: C12Q1/68 ,  C12Q1/6813 ,  C12Q1/6816 ,  G01N27/447 ,  G01N33/50 ,  G01N33/58 ,  C12Q1/28 ,  C12Q1/42

Abstract: A method of detecting a nucleic acid which comprises bringing a solid carrier suspected to carry or contain a nucleic acid into contact with a polyamine containing, bound thereto, a label capable of generating a detectable signal or a precursor thereof to thereby form a complex between a nucleic acid, if any, and the polyamine, removing the polyamine which has not formed any complex before or after the conversion of the precursor, if used, into the label, and detecting the label.