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    NOVEL SCAVENGER RECEPTORS
    1.
    发明公开
    NOVEL SCAVENGER RECEPTORS 有权
    范格-REZEPTOREN

    公开(公告)号：EP1262546A4

    公开(公告)日：2004-07-14

    申请号：EP01902805

    申请日：2001-02-08

    Applicant: FUSO PHARMACEUTICAL IND

    Inventor： WAKAMIYA NOBUTAKA

    IPC: A61K38/00 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  C07K14/705 ,  C12N1/21 ,  C12N15/12 ,  C12P21/08 ,  C07K14/47

    CPC classification number: C07K16/28 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/705 ,  G01N2500/00 ,  G01N2800/00 ,  G01N2800/32

    Abstract: Novel scavenger receptors having an SR structure and a collectin-like structure which are proteins having the amino acid sequences of SEQ ID NOS:2, 4 and 24 or proteins having comparable properties thereto, which are usable in clarifying the functions of macrophages and basal immunity, in clarifying the onset mechanisms of various diseases such as arteriosclerosis, diabetic complications, re-constriction after angioplasty and bacterial infection, in diagnosing, preventing and treating these diseases and in developing reagents and drugs therefor; and molecules related thereto such as derivatives or fragments thereof, isolated polynucleotides containing base sequences encoding the same, antibodies and antagonists. A treatment method by using these receptors is also disclosed.

    Abstract translation: 提供具有SR结构和集合蛋白样结构的新型清道夫受体，其可用于阐明巨噬细胞和基本免疫的机制; 阐明各种疾病如动脉硬化，糖尿病并发症和阿尔茨海默氏病，超级β-脂蛋白血症，高胆固醇血症，高甘油三酯血症，低α脂蛋白血症，移植，粥样斑块切除术，血管生成后再狭窄，细菌感染等各种疾病的发展机制; 在其诊断，预防和治疗方法中; 并在开发试剂和药物方面相同。 新型清道夫受体包括包含SEQ ID NO：2,4或24所示的氨基酸序列的蛋白质或与其相同性质的蛋白质或其衍生物或片段，以及包含编码这些蛋白质的核苷酸序列的分离的多核苷酸， 和相关分子如抗体，拮抗剂等。 还公开了使用其的治疗方法。

    RECOMBINANT CONGLUTININ AND PROCESS FOR PRODUCING THE SAME
    3.
    发明公开
    RECOMBINANT CONGLUTININ AND PROCESS FOR PRODUCING THE SAME 失效
    重组凝集素和方法及其

    公开(公告)号：EP0856580A4

    公开(公告)日：2001-02-07

    申请号：EP96901484

    申请日：1996-01-25

    Applicant: FUSO PHARMACEUTICAL IND

    Inventor： WAKAMIYA NOBUTAKA

    IPC: A61K38/00 ,  C07K14/47 ,  C12N1/21 ,  C12N15/12 ,  C07K14/435 ,  C12N15/67 ,  C12P21/02 ,  C12Q1/70

    CPC classification number: C07K14/47 ,  A61K38/00

    Abstract: A recombinant conglutinin which contains a collagen region consisting of six amino acids containing two amino acid sequences Gly-Xaa-Xaa (SEQ ID NO:3, wherein Xaa stands for a protein-constituting amino acid), the neck region of natural conglutinin and the sugar chain recognition region of natural conglutinin, has an antiviral activity (virus neutralizing activity), and is expected to be applicable to drugs; and a process for detecting anti-influenza A virus activity of a mannose-binding protein (MBP) or a human mannose-binding protein (hMBP) involving the step of treating influenza A virus-infected cells with the MBP or hMBP and measuring the level of the suppression of the budding of the virus in the virus-infected cells. An MBP and an hMBP having an anti-influenza A virus activity are disclosed.

    RECOMBINANT CONGLUTININ AND PROCESS FOR PRODUCING THE SAME
    5.
    发明公开
    RECOMBINANT CONGLUTININ AND PROCESS FOR PRODUCING THE SAME 失效
    重组凝集素和工艺及其生产

    公开(公告)号：EP0846701A4

    公开(公告)日：2001-02-07

    申请号：EP95933617

    申请日：1995-10-02

    Applicant: FUSO PHARMACEUTICAL IND

    Inventor： WAKAMIYA NOBUTAKA

    IPC: A61K38/00 ,  C07K14/47 ,  C12N15/12 ,  C12P21/02

    CPC classification number: C07K14/47 ,  A61K38/00

    Abstract: A recombinant conglutinin containing a collagen region comprising six amino acid residues containing two amino acid sequences Gly-Xaa-Xaa (SEQ ID NO:3, Xaa representing a protein-constituting amino acid residue), a neck region of natural conglutinin and a sugar-chain recognition region of natural conglutinin, having an antiviral activity (neutralizing activity), and being expected to be applicable for medicinal uses.

    RECOMBINANT HUMAN MANNAN BINDING PROTEIN AND ITS PRODUCTION
    8.
    发明专利
    RECOMBINANT HUMAN MANNAN BINDING PROTEIN AND ITS PRODUCTION 失效

    公开(公告)号：JPH11206378A

    公开(公告)日：1999-08-03

    申请号：JP1186498

    申请日：1998-01-23

    Applicant: FUSO PHARMACEUTICAL IND

    Inventor： WAKAMIYA NOBUTAKA

    IPC: C12N15/09 ,  A61K38/00 ,  A61P31/12 ,  A61P31/16 ,  C07K14/47 ,  C12N15/00 ,  C12N15/12 ,  C12P21/02 ,  C12R1/91

    Abstract: PROBLEM TO BE SOLVED: To provide a system for homogeneously producing a recombinant human mannan binding protein (rhMBP) having the same physiological activity as that of human mannan binding protein (hMBP). SOLUTION: A portion of 66 bp to 812 bp in the cDNA of a native human mannan binding protein (native hMBP) is sectioned and then inserted into an expression vector pNOW1 to construct an expression vector pNOW1-hMBP, which, in turn, is transferred into dihydrofolic acid reductanse-deficient (dhfr ) Chinese hamster ovarian(CHO) cells to afford the corresponding transformant, which is then cultured in a neomycin-contg. medium to produce neomycin- resistant cells, which, in turn, is cultured in a medium containing methotrexate(MTX) to afford MTX-resistant cells, from which the aimed rhMBP is recovered, being such that the absorbance at 280 nm when treated with gel filtration chromatography represents a specified peak with a molecular weight of 1,000-1,300 kDa.

    NEW COLLECTIN
    9.
    发明专利
    NEW COLLECTIN 失效

    公开(公告)号：JPH11206377A

    公开(公告)日：1999-08-03

    申请号：JP1128198

    申请日：1998-01-23

    Applicant: FUSO PHARMACEUTICAL IND

    Inventor： WAKAMIYA NOBUTAKA

    IPC: C12N15/09 ,  A01N37/46 ,  C07K14/47 ,  C07K14/78 ,  C12N15/12 ,  C12P21/00

    Abstract: PROBLEM TO BE SOLVED: To obtain a polynucleotide encoding a new collectin which exhibits antibacterial, antiviral activity or the like in vivo in humans and is useful as a physiologically active medicinal substance. SOLUTION: This polynucleotide contains a base sequence encoding a protein constituted of an amino acid sequence of the formula. This polynucleotide is obtained by the following procedure: regions with higher preservability among known collections are retrieved, an EST database is retrieved to afford data (registry number: R 29493) containing unknown base sequences; from a clone as the base of the above data, a probe for screening use is prepared; a human liver-derived cDNA library subjected to titration is screened with the probe, a positive clone is subjected to secondary screening in a similar way, the base sequence of the whole region of the plasmid of a transformant afforded by transformation with a DNA fragment based on the resulting positive clone is determined, thus obtaining the aimed cDNA clone encoding the amino acid sequence of the formula.

    Polypeptide Acting To Enhance Ischemic Diseases
    10.
    发明专利
    Polypeptide Acting To Enhance Ischemic Diseases 未知

    公开(公告)号：AU2011222224B2

    公开(公告)日：2014-02-13

    申请号：AU2011222224

    申请日：2011-03-04

    Applicant: FUSO PHARMACEUTICAL IND

    Inventor： WAKAMIYA NOBUTAKA ,  OTANI KATSUKI

    IPC: C12N15/09 ,  C07K14/47

    Abstract: Disclosed is a polypeptide of use in the development of reagents or medicines favourable to application for prevention or treatment of ischemic disorders such as conditions caused by ateriosclerosis. The polypeptide has at least one part containing an amino acid of sequence ID 1, and also enhances expression levels of the amino acid in mammalian blood vessels removed from ischemic conditions by means of blood reperfusion.

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