公开(公告)号：SE421796B

公开(公告)日：1982-02-01

申请号：SE7601337

申请日：1976-02-06

Applicant: GLAXO LAB LTD

Inventor： FLEMING I D ,  NOBLE D ,  NOBLE H M ,  WALL W F

IPC: C07D503/00 ,  C12P17/18 ,  C07D498/04

Abstract: The invention provides the compound (2R,5R,Z)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo-[3,2,0]hept ane-2-carboxylic acid and its salts in purified form and pharmaceutical compositions containing them and a process for the purification of such compounds by conversion in aqueous media to the lithium salt of the above acid and precipitation thereof.

公开(公告)号：SE7601337L

公开(公告)日：1976-11-03

申请号：SE7601337

申请日：1976-02-06

Applicant: GLAXO LAB LTD

Inventor： FLEMING I D ,  NOBLE D ,  NOBEL H M ,  WALL W F

IPC: C07D503/00 ,  C12P17/18 ,  C07D491/02 ,  C07D498/04

Abstract: The invention provides the compound (2R,5R,Z)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo-[3,2,0]hept ane-2-carboxylic acid and its salts in purified form and pharmaceutical compositions containing them and a process for the purification of such compounds by conversion in aqueous media to the lithium salt of the above acid and precipitation thereof.

公开(公告)号：AU509313B2

公开(公告)日：1980-05-08

申请号：AU1089176

申请日：1976-02-06

Applicant: GLAXO LAB LTD

Inventor： FLEMING I D ,  NOBLE D ,  NOBLE H M ,  WALL W F

IPC: C07D503/00 ,  C12P17/18 ,  C07D498/04 ,  C12D9/14

Abstract: The invention provides the compound (2R,5R,Z)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo-[3,2,0]hept ane-2-carboxylic acid and its salts in purified form and pharmaceutical compositions containing them and a process for the purification of such compounds by conversion in aqueous media to the lithium salt of the above acid and precipitation thereof.

公开(公告)号：DK49876A

公开(公告)日：1976-08-08

申请号：DK49876

申请日：1976-02-06

Applicant: GLAXO LAB LTD

Inventor： FLEMING I D ,  NOBLE D ,  NOBLE H M ,  WALL W F

IPC: C07D503/00 ,  C12P17/18

Abstract: The invention provides the compound (2R,5R,Z)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo-[3,2,0]hept ane-2-carboxylic acid and its salts in purified form and pharmaceutical compositions containing them and a process for the purification of such compounds by conversion in aqueous media to the lithium salt of the above acid and precipitation thereof.

公开(公告)号：YU29076A

公开(公告)日：1982-08-31

申请号：YU29076

申请日：1976-02-06

Applicant: GLAXO LAB LTD

Inventor： FLEMING I D ,  NOBEL D ,  NOBLE H ,  WALL W

IPC: C07D503/00 ,  C12P17/18 ,  C07D498/00 ,  A61K31/33

Abstract: The invention provides the compound (2R,5R,Z)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo-[3,2,0]hept ane-2-carboxylic acid and its salts in purified form and pharmaceutical compositions containing them and a process for the purification of such compounds by conversion in aqueous media to the lithium salt of the above acid and precipitation thereof.

公开(公告)号：DK207378A

公开(公告)日：1978-05-11

申请号：DK207378

申请日：1978-05-11

Applicant: GLAXO LAB LTD

Inventor： FLEMING I D ,  NOBLE D ,  NOBLE H M ,  WWLL W F

IPC: C07D20060101 ,  C07D498/04 ,  C07D