公开(公告)号：KR800001241B1

公开(公告)日：1980-10-25

申请号：KR760000291

申请日：1976-02-06

Applicant: GLAXO LAB LTD

Inventor： NOBLE D ,  WALL W ,  NOBLE H

IPC: C07D498/04

Abstract: Title compd. (I) useful as antibiotics, and its salts were prepd. from the culture filtrate of Streptomyces clavuligerus NRRL 3585. Thus, 25l inoculum grown on a complex medium was mixed with 475l of a medium contg. soybean meal 3.0, FeSO47H2O 0.01, K2HPO40.01, sol. starch 4.7%, and silicon antifoaming agent 0.05% and cultured in 700l fermentor for 2 hr at 28≦̸C and pH 6.5 with agitation and aeration at 0.56 v/v/min. The culture filtrate was decolorized with active C, the column washed with 90l water, and I eluted with 180l of 60% acetone.

公开(公告)号：YU29076A

公开(公告)日：1982-08-31

申请号：YU29076

申请日：1976-02-06

Applicant: GLAXO LAB LTD

Inventor： FLEMING I D ,  NOBEL D ,  NOBLE H ,  WALL W

IPC: C07D503/00 ,  C12P17/18 ,  C07D498/00 ,  A61K31/33

Abstract: The invention provides the compound (2R,5R,Z)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo-[3,2,0]hept ane-2-carboxylic acid and its salts in purified form and pharmaceutical compositions containing them and a process for the purification of such compounds by conversion in aqueous media to the lithium salt of the above acid and precipitation thereof.

公开(公告)号：SE336431B

公开(公告)日：1971-07-05

申请号：SE900567

申请日：1967-06-22

Applicant: GLAXO LAB LTD

Inventor： O'CALLAGHAN C ,  GREGORY G ,  LONG A ,  BOOTHROYD B ,  BAIN B ,  WALL W

IPC: A61K31/545 ,  C07D501/20 ,  C07D501/24 ,  C07D501/38 ,  A61K21/00

Abstract: Broad-spectrum antibiotics are prepared by combining a broad-spectrum cephalosporin antibiotic (A) which is subject to decomposition by beta-lactamase, with a cephalosporin antibiotic (B) which is beta-lactamase resistant. Cephalosporin antibiotic (A) of general formula (I): R4 = 2-thienylmethyl or D-alpha-amino alpha-phenylmethyl; R5 = an acetate group or, in the betaine-form with the adjacent carboxyl group, a Py+ group; Py = N-pyridyl or subst. N-pyridyl group. Cephalosporin antibiotic (B) The new preparations contain a cephalosporin antibiotic (II) which is resistant to decomposition caused by beta-lactamase produced by Proteus morgani. The antibiotic (I) with broad spectrum is protected by (II) which increases the spectrum and/or its activity.

公开(公告)号：SE334891B

公开(公告)日：1971-05-10

申请号：SE803663

申请日：1963-07-19

Applicant: GLAXO LAB LTD

Inventor： BOOTHROYD B ,  WALL W ,  FATHERLEY M

IPC: A61K31/545 ,  C07D501/26 ,  C07D501/28 ,  C07D501/32 ,  C07D99/24

公开(公告)号：DK118083B

公开(公告)日：1970-07-06

申请号：DK319163

申请日：1963-07-05

Applicant: GLAXO LAB LTD

Inventor： WALL W ,  FATHERLEY M ,  BOOTHROYD B

IPC: A61K31/545 ,  C07D501/26 ,  C07D501/28 ,  C07D501/32 ,  C07D99/24