公开(公告)号：KR800001241B1

公开(公告)日：1980-10-25

申请号：KR760000291

申请日：1976-02-06

Applicant: GLAXO LAB LTD

Inventor： NOBLE D ,  WALL W ,  NOBLE H

IPC: C07D498/04

Abstract: Title compd. (I) useful as antibiotics, and its salts were prepd. from the culture filtrate of Streptomyces clavuligerus NRRL 3585. Thus, 25l inoculum grown on a complex medium was mixed with 475l of a medium contg. soybean meal 3.0, FeSO47H2O 0.01, K2HPO40.01, sol. starch 4.7%, and silicon antifoaming agent 0.05% and cultured in 700l fermentor for 2 hr at 28≦̸C and pH 6.5 with agitation and aeration at 0.56 v/v/min. The culture filtrate was decolorized with active C, the column washed with 90l water, and I eluted with 180l of 60% acetone.

公开(公告)号：YU29076A

公开(公告)日：1982-08-31

申请号：YU29076

申请日：1976-02-06

Applicant: GLAXO LAB LTD

Inventor： FLEMING I D ,  NOBEL D ,  NOBLE H ,  WALL W

IPC: C07D503/00 ,  C12P17/18 ,  C07D498/00 ,  A61K31/33

Abstract: The invention provides the compound (2R,5R,Z)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo-[3,2,0]hept ane-2-carboxylic acid and its salts in purified form and pharmaceutical compositions containing them and a process for the purification of such compounds by conversion in aqueous media to the lithium salt of the above acid and precipitation thereof.