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    ASSAY DEVICE AND METHOD
    3.
    发明专利
    ASSAY DEVICE AND METHOD 未知

    公开(公告)号：CA2564609C

    公开(公告)日：2014-02-11

    申请号：CA2564609

    申请日：2004-12-29

    Applicant: HARVARD COLLEGE

    Inventor： SIA SAMUEL K ,  LINDER VINCENT ,  PARVIZ BABAK A ,  SIEGEL ADAM ,  WHITESIDES GEORGE M

    IPC: G01N21/53 ,  B01L3/00 ,  G01N21/05 ,  G01N21/59 ,  G01N33/53 ,  G01N33/58

    Abstract: An assay method is described, which comprises the steps of immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion (140) of a surface (130) of a microfluidic chamber (120,122,124); passing a fluid sample over the surface and allowing the analyte to bind to the binding partner; allowing a metal colloid, e.g., a gold-conjugated antibody, to associate with the bound analyte; flowing a metal solution, e.g., a silver solution, over the surface such as to form an opaque metallic layer; and detecting the presence of said metallic layer, e.g., by visual inspection or by measuring light transmission through the layer, conductivity or resistance of the layer, or metal concentration in the metal solution after flowing the metal solution over the surface.

    FLUIDIC STRUCTURES INCLUDING MEANDERING AND WIDE CHANNELS
    4.
    发明专利
    FLUIDIC STRUCTURES INCLUDING MEANDERING AND WIDE CHANNELS 未知

    公开(公告)号：CA2604323A1

    公开(公告)日：2006-10-26

    申请号：CA2604323

    申请日：2006-04-19

    Applicant: HARVARD COLLEGE

    Inventor： NAROVLYANSKY MAX ,  SIA SAMUEL K ,  WHITESIDES GEORGE M ,  SIEGEL ADAM ,  LINDER VINCENT

    IPC: G01N21/59 ,  B01L3/00 ,  G01N33/543 ,  G01N33/553

    Abstract: The present invention relates generally to microfluidic structures, and more specifically, to microfluidic structures and methods including meandering an d wide channels. Microfluidic systems can provide an advantageous environment for performing various reactions and analyses due to a reduction in sample a nd reagent quantities that are required, a reduction in the size of the operati ng system, and a decrease in reaction time compared to conventional systems. Unfortunately, the small size of microfluidic channels can sometimes result in difficulty in detecting a species without magnifying optics (such as a microscope or a photomultiplier). A series of tightly packed microchannels, i.e., a meandering region, or a wide channel having a dimension on the order of millimeters, can serve as a solution to this problem by creating a wide measurement area. Although this invention mainly describes the use of meandering and wide channels in heterogeneous immunoassays on a microfluidic chip, this invention could be used for amplifying optical signals for other types of reactions and/or assays.

    ASSAY DEVICE AND METHOD
    6.
    发明专利
    ASSAY DEVICE AND METHOD 未知

    公开(公告)号：CA2834041C

    公开(公告)日：2017-05-16

    申请号：CA2834041

    申请日：2004-12-29

    Applicant: HARVARD COLLEGE

    Inventor： SIA SAMUEL K ,  LINDER VINCENT ,  PARVIZ BABAK A ,  SIEGEL ADAM ,  WHITESIDES GEORGE M

    IPC: G01N33/543 ,  B01L3/00 ,  B81B1/00 ,  G01N21/05 ,  G01N21/53 ,  G01N21/59 ,  G01N33/53 ,  G01N33/58

    Abstract: An assay method is described, which comprises the steps of immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion of a surface of a microfluidic chamber; passing a fluid sample over the surface and allowing the analyte to bind to the binding partner; allowing a metal colloid, e.g., a gold- conjugated antibody, to associate with the bound analyte; flowing a metal solution, e.g., a silver solution, over the surface such as to form an opaque metallic layer; and detecting the presence of said metallic layer, e.g., by visual inspection or by measuring light transmission through the layer, conductivity or resistance of the layer, or metal concentration in the metal solution after flowing the metal solution over the surface.

    Fluidic structures including meandering and wide channels
    9.
    发明专利
    Fluidic structures including meandering and wide channels 未知

    公开(公告)号：AU2006236410B2

    公开(公告)日：2012-11-01

    申请号：AU2006236410

    申请日：2006-04-19

    Applicant: HARVARD COLLEGE

    Inventor： LINDER VINCENT ,  WHITESIDES GEORGE M ,  SIEGEL ADAM ,  NAROVLYANSKY MAX ,  SIA SAMUEL K

    IPC: B01L3/00 ,  G01N21/59 ,  G01N33/543 ,  G01N33/553

    Abstract: The present invention relates generally to microfluidic structures, and more specifically, to microfluidic structures and methods including meandering and wide channels. Microfluidic systems can provide an advantageous environment for performing various reactions and analyses due to a reduction in sample and reagent quantities that are required, a reduction in the size of the operating system, and a decrease in reaction time compared to conventional systems. Unfortunately, the small size of microfluidic channels can sometimes result in difficulty in detecting a species without magnifying optics (such as a microscope or a photomultiplier). A series of tightly packed microchannels, i.e., a meandering region, or a wide channel having a dimension on the order of millimeters, can serve as a solution to this problem by creating a wide measurement area. Although this invention mainly describes the use of meandering and wide channels in heterogeneous immunoassays on a microfluidic chip, this invention could be used for amplifying optical signals for other types of reactions and/or assays.

    Assay device and method
    10.
    发明专利
    Assay device and method 未知

    公开(公告)号：AU2004312893B2

    公开(公告)日：2010-06-17

    申请号：AU2004312893

    申请日：2004-12-29

    Applicant: HARVARD COLLEGE

    Inventor： LINDER VINCENT ,  PARVIZ BABAK A ,  WHITESIDES GEORGE M ,  SIEGEL ADAM ,  SIA SAMUEL K

    IPC: B01L3/00 ,  G01N21/05 ,  G01N21/53 ,  G01N21/59 ,  G01N33/53 ,  G01N33/58

    Abstract: An assay device and method are described. The assay may involve immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion of a surface of a microfluidic chamber; passing a fluid sample over the surface and allowing the analyte to bind to the binding partner; allowing a metal colloid, e.g., a gold-conjugated antibody, to associate with the bound analyte; flowing a metal solution, e.g., a silver solution, over the surface such as to form an opaque metallic layer; and detecting the presence of said metallic layer, e.g., by visual inspection or by measuring light transmission through the layer, conductivity or resistance of the layer, or metal concentration in the metal solution after flowing the metal solution over the surface.

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