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公开(公告)号：WO2021086313A1
公开(公告)日：2021-05-06
申请号：PCT/US2019/058427
申请日：2019-10-29
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： CHOY, Si-lam J. , ELY, Hilary , LAHMANN, John , DAALKHAIJAV, Uranbileg , GISH, Sarah
IPC: C12M3/02 , C12M3/06 , C12Q1/6806 , G01N33/50 , B81B1/00
Abstract: A biological component concentration fluid assembly includes magnetizing microparticles that are surface-activated to bind with (or are bound to) a biological component; a multi-fluid density gradient column with a first fluid layer, a second fluid layer, and a third fluid layer; and a magnet to attract and draw the magnetizing microparticles from the first fluid layer, through the second fluid layer, and into the third fluid layer. The first fluid layer has a first fluid density, and a second fluid layer has a second fluid density that is greater than the first fluid density, and is positioned beneath the first fluid layer. A third fluid layer has a third fluid density that is greater than the second fluid density and is positioned beneath the second fluid layer. The second and third fluid layers in this example are formulated to interact with the surface of the magnetizing microparticles.
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公开(公告)号：WO2018194615A1
公开(公告)日：2018-10-25
申请号：PCT/US2017/028604
申请日：2017-04-20
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： WHITE, Rachel M. , SMITH, Matthew David , ZAVAREHI, Masoud , DAALKHAIJAV, Uranbileg , YU, Joshua M. , DOMINGUE, Chantelle
CPC classification number: G01N33/4905 , G01N33/86
Abstract: A microfluidic coagulation analysis method includes introducing a fluid sample into a measurement device including a pinch point that includes a microfluidic channel of substantially consistent width and height connecting a slot and a chamber. The at least one pinch point permits passage of the fluid sample from the slot to the chamber. The method further includes measuring, with a sensor in or near the pinch point, transits of individual cells in the sample passing through the at least one pinch point, and computing, at least in part with a processor, at least one metric indicative of a time period during which the flow of the sample transitions from substantially fluid flow to substantial cessation of flow.
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公开(公告)号：WO2018194613A1
公开(公告)日：2018-10-25
申请号：PCT/US2017/028586
申请日：2017-04-20
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： DAALKHAIJAV, Uranbileg , WHITE, Rachel M. , WOODFORD, Tod , DOMINGUE, Chantelle
Abstract: A microfluidic blood coagulation testing die includes a substrate, a slot in the substrate permitting entry of a sample of blood, a chamber in the substrate for collection of cells in the sample, and a pinch point that permits passage of sample from slot to chamber. The die includes a sensor in or near the at least one pinch point to test sample passing through the at least one pinch point. Activator, such as freeze-dried coagulation-initializing tissue factor, coats at least a portion of the interior surface of the slot, pinch point, and chamber.
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Patent Agency Ranking
公开(公告)号：WO2018194700A1
公开(公告)日：2018-10-25
申请号：PCT/US2017/044543
申请日：2017-07-28
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： WHITE, Rachel M. , DAALKHAIJAV, Uranbileg
Abstract: A microfluidic reaction system may include a microfluidic die having a microfluidic volume, a port connected to the microfluidic volume for receiving a fluid and a freeze-dried reaction agent coating at least a portion of the microfluidic volume.
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公开(公告)号：WO2019103743A1
公开(公告)日：2019-05-31
申请号：PCT/US2017/063102
申请日：2017-11-22
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： WHITE, Rachel M. , CUMBIE, Michael W. , DAALKHAIJAV, Uranbileg
Abstract: The present disclosure is drawn to microfluidic devices for blood coagulation. The microfluidic device can include a substrate, a lid mounted to the substrate, and a microchip mounted to the substrate. The lid and substrate can form a discrete microfluidic chamber between structures including an interior surface of the lid and a portion of the substrate. The lid can also include an inlet and a vent positioned relative to one another to facilitate loading of a fluid to the discrete microfluidic chamber via capillary action. A portion of the microchip can include a blood coagulation component positioned within the discrete microfluidic chamber.
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公开(公告)号：WO2018194610A1
公开(公告)日：2018-10-25
申请号：PCT/US2017/028574
申请日：2017-04-20
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： WHITE, Rachel M. , DAALKHAIJAV, Uranbileg , WOODFORD, Tod , DOMINGUE, Chantelle
Abstract: A microfluidic blood coagulation testing die includes a substrate, a slot defined in the substrate permitting entry of a blood sample, a chamber defined in the substrate that collects red blood cells from the blood sample, and a microfluidic path that provides a fluid connection from the slot to the chamber. The microfluidic path includes a channel, an inlet disposed at one end of the channel and an outlet disposed at the other end of the channel.
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公开(公告)号：EP3990616A1
公开(公告)日：2022-05-04
申请号：EP19951197.3
申请日：2019-10-29
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： CHOY, Si-lam J. , ELY, Hilary , LAHMANN, John , DAALKHAIJAV, Uranbileg , GISH, Sarah
IPC: C12M3/02 , C12M3/06 , C12Q1/6806 , G01N33/50 , B81B1/00
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公开(公告)号：EP3582893A1
公开(公告)日：2019-12-25
申请号：EP17905928.2
申请日：2017-07-28
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： WHITE, Rachel M. , DAALKHAIJAV, Uranbileg
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