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公开(公告)号:WO2018022026A1
公开(公告)日:2018-02-01
申请号:PCT/US2016/044099
申请日:2016-07-26
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor: DOMINGUE, Chantelle , WOODFORD, Tod , GIRI, Manish , SMITH, Matthew David , CORRIGAN III, George H. , ZAVAREHI, Masoud , YU, Joshua M.
Abstract: According to an example, a microfluidic apparatus may include a fluid slot and a foyer that is in fluid communication with the fluid slot via a channel having a relatively smaller width than the foyer. The microfluidic apparatus may also include an electrical sensor to measure a change in an electrical field caused by a particle of interest in a fluid passing through the channel from the fluid slot to the foyer, an actuator to apply pressure onto fluid contained in the foyer, and a controller to receive the measured change in the electrical field from the electrical sensor, determine, from the received change in the electrical field, an electrical signature of the particle of interest, and control the actuator to control movement of the particle of interest based upon the determined electrical signature of the particle of interest.
Abstract translation: 根据一个实例,微流体装置可以包括流体槽和通过宽度比所述门厅的宽度相对小的通道与流体槽流体连通的门厅。 微流体装置还可以包括电传感器,用于测量由流体通过通道从流体槽到门厅的流体中感兴趣的颗粒引起的电场的变化;致动器,将压力施加到包含在门厅中的流体上; 以及控制器,用于从电传感器接收所测得的电场变化,根据所接收的电场变化来确定感兴趣的粒子的电特征,并且控制该致动器以基于 根据感兴趣的颗粒的确定的电子签名。 p>
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公开(公告)号:WO2021201836A1
公开(公告)日:2021-10-07
申请号:PCT/US2020/025883
申请日:2020-03-31
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor: GOVYADINOV, Alexander , LAZAROFF, Dennis M. , DAHLGREN, Brett E. , LUCCHINI, Stefan Enr , WOODFORD, Tod
Abstract: The present disclosure is drawn to microfluidic devices. The microfluidic device includes a microfluidic well, a layered composite stack, and an optical sensor. The layered composite stack includes an optical filter composited with an etch-stopping layer. The optical filter defines the microfluidic well. The optical sensor is associated with the microfluidic well and has the optical filter positioned therebetween.
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公开(公告)号:WO2021021079A1
公开(公告)日:2021-02-04
申请号:PCT/US2019/043650
申请日:2019-07-26
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor: WILLARD, Randall Orson , POLLARD, Jeffrey R. , GOVYADINOV, Alexander , WOODFORD, Tod
Abstract: The present disclosure is drawn to microfluidic devices. The microfluidic device includes a substrate, an optically translucent lid, an adhesive securing the substrate to the lid, and an optical barrier material between the substrate and the optically translucent lid.
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公开(公告)号:WO2019209302A1
公开(公告)日:2019-10-31
申请号:PCT/US2018/029586
申请日:2018-04-26
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor: GISH, Sarah , WOODFORD, Tod , GOVYADINOV, Alexander
Abstract: An example device includes a processor to connect to an electrode disposed within a microfluidic volume and to connect a second electrode that includes a surface of silver metal disposed within the microfluidic volume. The processor is to apply an electrical potential between the electrode and the second electrode when the microfluidic volume contains a fluid that contains chloride ions to form a layer of silver chloride on the surface of the second electrode. The processor is further to cease application of the electrical potential and operate the second electrode as a reference electrode in a measurement process performed within the microfluidic volume.
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公开(公告)号:WO2018194613A1
公开(公告)日:2018-10-25
申请号:PCT/US2017/028586
申请日:2017-04-20
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor: DAALKHAIJAV, Uranbileg , WHITE, Rachel M. , WOODFORD, Tod , DOMINGUE, Chantelle
Abstract: A microfluidic blood coagulation testing die includes a substrate, a slot in the substrate permitting entry of a sample of blood, a chamber in the substrate for collection of cells in the sample, and a pinch point that permits passage of sample from slot to chamber. The die includes a sensor in or near the at least one pinch point to test sample passing through the at least one pinch point. Activator, such as freeze-dried coagulation-initializing tissue factor, coats at least a portion of the interior surface of the slot, pinch point, and chamber.
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公开(公告)号:WO2017131730A1
公开(公告)日:2017-08-03
申请号:PCT/US2016/015568
申请日:2016-01-29
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor: WOODFORD, Tod , ELY, Hilary , BENGALI, Sadiq
CPC classification number: G01N27/02
Abstract: An electrode system and a method of using an electrode system to make an impedance measurement. The electrode system comprises a substrate that supports a first and second electrodes. The first electrode is located inside a cutout of the second electrode. The first and second electrodes are separated by an insulating layer.
Abstract translation: 电极系统和使用电极系统进行阻抗测量的方法。 该电极系统包括支撑第一和第二电极的基板。 第一电极位于第二电极的切口内。 第一和第二电极被绝缘层分开。 p>
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公开(公告)号:WO2019103729A1
公开(公告)日:2019-05-31
申请号:PCT/US2017/062925
申请日:2017-11-22
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor: ELY, Hilary , HIGGINS, Adam , WHITE, Rachel M. , TORNIAINEN, Erik D. , WOODFORD, Tod , CUMBIE, Michael W. , CHEN, Chien-Hua
Abstract: The present disclosure is drawn to microfluidic devices. A microfluidic device can include a substrate, a lid mounted to the substrate, and a microchip mounted to the substrate. The lid mounted to the substrate can form a discrete microfluidic chamber between structures including an interior surface of the lid and a portion of the substrate. The lid can include an inlet and a vent positioned relative to one another to facilitate loading of fluid to the discrete microfluidic chamber via capillary action. A portion of the microchip can be positioned within the discrete microfluidic chamber.
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公开(公告)号:WO2018194610A1
公开(公告)日:2018-10-25
申请号:PCT/US2017/028574
申请日:2017-04-20
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor: WHITE, Rachel M. , DAALKHAIJAV, Uranbileg , WOODFORD, Tod , DOMINGUE, Chantelle
Abstract: A microfluidic blood coagulation testing die includes a substrate, a slot defined in the substrate permitting entry of a blood sample, a chamber defined in the substrate that collects red blood cells from the blood sample, and a microfluidic path that provides a fluid connection from the slot to the chamber. The microfluidic path includes a channel, an inlet disposed at one end of the channel and an outlet disposed at the other end of the channel.
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公开(公告)号:WO2018067177A1
公开(公告)日:2018-04-12
申请号:PCT/US2016/056087
申请日:2016-10-07
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor: GIRI, Manish , DOMINGUE, Chantelle , WOODFORD, Tod , SMITH, Matthew David , WHITE, Rachel M. , YU, Joshua M. , ELY, Hilary , SELLS, Jeremy
IPC: B01L3/00
Abstract: The present disclosure is drawn to microfluidic chips. The microfluidic chips can include an inflexible material having an elastic modulus of 0.1 gigapascals (GPa) to 450 GPa. A microfluidic channel can be formed within the inflexible material and can connect an inlet and an outlet. A working electrode can be associated with the microfluidic channel and can have a surface area of 1 μm 2 to 60,000 μm 2 within the microfluidic channel. A bubble support structure can also be formed within the microfluidic channel such that the working electrode is positioned to electrolytically generate a bubble that becomes associated with the bubble support structure.
Abstract translation: 本公开涉及微流体芯片。 微流体芯片可以包括具有0.1千兆帕斯卡(GPa)至450GPa的弹性模量的非柔性材料。 微流体通道可以形成在不可弯曲的材料内并且可以连接入口和出口。 工作电极可以与微流体通道相关联,并且可以在微流体通道内具有1μm2至60,000μm2的表面积。 气泡支撑结构也可以形成在微流体通道内,使得工作电极被定位成电解产生与气泡支撑结构相关的气泡。 p>
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公开(公告)号:EP3658488A1
公开(公告)日:2020-06-03
申请号:EP17933061.8
申请日:2017-11-22
Applicant: Hewlett-Packard Development Company, L.P.
Inventor: ELY, Hilary , HIGGINS, Adam , WHITE, Rachel M. , TORNIAINEN, Erik D. , WOODFORD, Tod , CUMBIE, Michael W. , CHEN, Chien-Hua
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