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公开(公告)号：WO2018194700A1
公开(公告)日：2018-10-25
申请号：PCT/US2017/044543
申请日：2017-07-28
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： WHITE, Rachel M. , DAALKHAIJAV, Uranbileg
Abstract: A microfluidic reaction system may include a microfluidic die having a microfluidic volume, a port connected to the microfluidic volume for receiving a fluid and a freeze-dried reaction agent coating at least a portion of the microfluidic volume.
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公开(公告)号：WO2019182612A1
公开(公告)日：2019-09-26
申请号：PCT/US2018/024047
申请日：2018-03-23
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： WHITE, Rachel M.
Abstract: An example method includes introducing a nucleic acid sample, a fluorescent indicator, and an internal positive control into a reaction volume of a microfluidic device. The example method further includes conducting a nucleic acid amplification reaction in the reaction volume, and optically monitoring a fluorescent signal from the reaction volume over a duration. A concentration of the internal positive control is selected to exhibit an initial increase in the fluorescent signal within the duration. The initial increase is to occur prior to a subsequent increase to be exhibited by an amplification product of a target when the target is present in the nucleic acid sample.
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公开(公告)号：WO2018194615A1
公开(公告)日：2018-10-25
申请号：PCT/US2017/028604
申请日：2017-04-20
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： WHITE, Rachel M. , SMITH, Matthew David , ZAVAREHI, Masoud , DAALKHAIJAV, Uranbileg , YU, Joshua M. , DOMINGUE, Chantelle
CPC classification number: G01N33/4905 , G01N33/86
Abstract: A microfluidic coagulation analysis method includes introducing a fluid sample into a measurement device including a pinch point that includes a microfluidic channel of substantially consistent width and height connecting a slot and a chamber. The at least one pinch point permits passage of the fluid sample from the slot to the chamber. The method further includes measuring, with a sensor in or near the pinch point, transits of individual cells in the sample passing through the at least one pinch point, and computing, at least in part with a processor, at least one metric indicative of a time period during which the flow of the sample transitions from substantially fluid flow to substantial cessation of flow.
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公开(公告)号：WO2019143392A1
公开(公告)日：2019-07-25
申请号：PCT/US2018/054265
申请日：2018-10-03
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： ELY, Hilary , CUMBIE, Michael W. , HIGGINS, Adam , WHITE, Rachel M. , TORNIAINEN, Erik D.
Abstract: A fluid thermal processing device may include a substrate, a platform projecting from the substrate, a fluid heating element supported by the platform, a temperature sensing element, distinct from the fluid heating element, supported by the platform and an enclosure supported by and cooperating with the substrate to form a fluid chamber about the platform. The fluid chamber forms a volume of uniform thickness conforming to and about the platform.
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公开(公告)号：WO2018194613A1
公开(公告)日：2018-10-25
申请号：PCT/US2017/028586
申请日：2017-04-20
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： DAALKHAIJAV, Uranbileg , WHITE, Rachel M. , WOODFORD, Tod , DOMINGUE, Chantelle
Abstract: A microfluidic blood coagulation testing die includes a substrate, a slot in the substrate permitting entry of a sample of blood, a chamber in the substrate for collection of cells in the sample, and a pinch point that permits passage of sample from slot to chamber. The die includes a sensor in or near the at least one pinch point to test sample passing through the at least one pinch point. Activator, such as freeze-dried coagulation-initializing tissue factor, coats at least a portion of the interior surface of the slot, pinch point, and chamber.
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Patent Agency Ranking
公开(公告)号：WO2019147216A1
公开(公告)日：2019-08-01
申请号：PCT/US2018/014785
申请日：2018-01-23
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： SMITH, Matthew David , WHITE, Rachel M.
Abstract: A direct current drive circuitry device can include a pull-up resistor to receive an input voltage and an electrical interface positioned in series and downstream from the pull-up resistor. The electrical interface can be electrically coupleable to a grounded microfluidic sensor to form a voltage divider circuit in combination with the pull-up resistor to generate an output voltage at the voltage divider circuit. The circuit can include an electrical switch to receive and charge cycle (discharging period and a charging period) the input voltage to the pull-up resistor of the voltage divider circuit. An analog-to-digital convertor can be electrically coupled to the voltage divider circuit (once completed) to measure the output voltage. A voltage buffer amplifier can be positioned between the voltage divider circuit and the analog-to-digital converter to prevent the analog-to-digital converter from loading the voltage divider circuit.
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公开(公告)号：WO2019103732A1
公开(公告)日：2019-05-31
申请号：PCT/US2017/062943
申请日：2017-11-22
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： TORNIAINEN, Erik D. , ELY, Hilary , CUMBIE, Michael W. , WHITE, Rachel M. , HIGGINS, Adam
IPC: B01L3/00
Abstract: A multizonal microfluidic device can include a substrate with multiple structures mounted thereon, including a first and second lid, and a first and second microchip. The first lid and the substrate can form a first microfluidic chamber between structures including a first interior surface of the first lid and a first discrete portion of the substrate. The first lid can include a first inlet and a first vent positioned relative to one another to facilitate loading of fluid to the first microfluidic chamber via capillary action. A portion of the first microchip can be positioned within the first microfluidic chamber. Furthermore, the second lid can be configured like the first lid and can also be mounted on the substrate forming a second microfluidic chamber with the second microchip positioned within the second microfluidic chamber.
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公开(公告)号：WO2017123267A1
公开(公告)日：2017-07-20
申请号：PCT/US2016/021222
申请日：2016-03-07
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： WHITE, Rachel M. , GIRI, Manish , DOMINGUE, Chantelle , YU, Joshua M. , SMITH, Matthew David , SHAMEED, Sait M A
CPC classification number: B01L3/5027 , B01L2300/0645 , B01L2300/0663 , B01L2400/0406 , B01L2400/0442 , B01L2400/0487 , G01N33/49 , G01N33/6893 , G01N33/86
Abstract: Examples herein provide a device. The device includes a testing cassette including: a microfluidic channel connecting an input port at a first end to at least one sensor area at a second end, the channel is to allow a blood sample to flow from the input port to the at least one sensor area; at least two electrodes; and a micro-fabricated integrated sensor, wherein when an electrical potential difference is applied over the blood sample, the sensor is to measure, over a duration of time, an electrical signal passing through the blood sample as the blood sample flows from the input port to the at least one sensor area and begin to coagulate, thereby obtaining a measurement function as a function of time. The device includes a processor to correlate the measurement function to a characteristic of the blood sample.
Abstract translation: 这里的示例提供了一种装置。 该装置包括测试盒，该测试盒包括：将第一端处的输入端口连接到第二端处的至少一个传感器区域的微流体通道，该通道允许血液样本从输入端口流动到至少一个传感器 区; 至少两个电极; 以及微制造的集成传感器，其中当电位差施加在血液样本上时，传感器在一段时间内测量当血液样本从输入端口流过时通过血液样本的电信号 到至少一个传感器区域并开始凝结，从而获得作为时间函数的测量功能。 该设备包括处理器，以将测量功能与血液样本的特征相关联。
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公开(公告)号：WO2017123266A1
公开(公告)日：2017-07-20
申请号：PCT/US2016/021219
申请日：2016-03-07
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： SHAMEED, Sait M A , WHITE, Rachel M. , DOMINGUE, Chantelle , GIRI, Manish
Abstract: Examples herein provide a method. The method includes applying an electrical potential difference over a blood sample in a testing cassette of a microfluidic device, the cassette including a microfluidic channel through which the blood sample flows. The method includes measuring, over a duration of time, an electrical signal passing through the blood sample as the blood sample flows from a first end and coagulates at a second end of the microfluidic channel to obtain a measurement function as a function of time. The method also includes correlating the measurement function to a characteristic of the blood sample.
Abstract translation: 这里的示例提供了一种方法。 该方法包括在微流体装置的测试盒中的血液样本上施加电势差，该盒包括血液样本流经的微流体通道。 该方法包括在一段时间内测量当血液样本从第一端流动并且在微流体通道的第二端凝结时通过血液样本的电信号，以获得作为时间的函数的测量函数。 该方法还包括将测量功能与血样的特征相关联。
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公开(公告)号：WO2019103743A1
公开(公告)日：2019-05-31
申请号：PCT/US2017/063102
申请日：2017-11-22
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： WHITE, Rachel M. , CUMBIE, Michael W. , DAALKHAIJAV, Uranbileg
Abstract: The present disclosure is drawn to microfluidic devices for blood coagulation. The microfluidic device can include a substrate, a lid mounted to the substrate, and a microchip mounted to the substrate. The lid and substrate can form a discrete microfluidic chamber between structures including an interior surface of the lid and a portion of the substrate. The lid can also include an inlet and a vent positioned relative to one another to facilitate loading of a fluid to the discrete microfluidic chamber via capillary action. A portion of the microchip can include a blood coagulation component positioned within the discrete microfluidic chamber.
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