公开(公告)号：JPH09255561A

公开(公告)日：1997-09-30

申请号：JP9618096

申请日：1996-03-26

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： MORI KENJI ,  ADACHI HIROTOSHI ,  MORIMOTO KAZUTOSHI ,  SUGIBAYASHI KENJI

IPC: A61N1/30 ,  A61K9/107 ,  A61M37/00

Abstract: PROBLEM TO BE SOLVED: To obtain a microemulsion preparation synergistically raised in medicinal delivery effect. SOLUTION: This micremulsion preparation is intended to increase medicinal absorption vivo through its administration to electroporation-applied site(s). The microemulsion comprises an aqueous phase (e.g. water, buffer solution), oily phase (e.g. soybean oil, fatty acid triglyceride), surfactant (e.g. polyoxyethylene hydrogenated castor oil) and a medicinal agent. The particle size for the microemulsion is such that >=90% of the total particles falls within the range from 0.1 to 100nm in size. This microemulsion preparation stands integrated with electrodes for elecroporation. Electroporation develops fine holes serving as transmission route in the skin of mucous membrane, through which the medicinal agent encapsulated in the readily absorbable microemulsion fine particles are absorbed; thus yielding higher medicinal virtues.

公开(公告)号：JP2003210591A

公开(公告)日：2003-07-29

申请号：JP2002015378

申请日：2002-01-24

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： MORI KENJI ,  TOKUMOTO SEIJI ,  HIGO SHIGETO ,  SATO HIDEJI ,  SUGIBAYASHI KENJI

IPC: A61K9/70 ,  A61K31/05 ,  A61K31/155 ,  A61K31/192 ,  A61K31/196 ,  A61K31/375 ,  A61K47/36 ,  A61N1/30 ,  A61P25/04 ,  A61P39/06 ,  A61P43/00

Abstract: PROBLEM TO BE SOLVED: To provide a percutaneous transmucosal applying preparation for electroporation in which an administration compound such as a drug can be effectively administered. SOLUTION: The percutaneous transmucosal applying preparation for electroporation has a drug storing layer 11 in which the administration compound (a biologically active substance) such as a drug is dispersed in a base in a solid or semisolid form, a backing 12 for holding the drug storing layer, and a pair of electrodes 13 for electroporation placed on the drug storing layer 11. An adhesive layer 14 is placed in the flange portion of the backing 12. An insulating layer 15 is placed in a part touching at least an applying part except for the upper part of the drug storing layer 11 of the electrode 13 for electroporation. COPYRIGHT: (C)2003,JPO

公开(公告)号：JPH09187520A

公开(公告)日：1997-07-22

申请号：JP2049996

申请日：1996-01-10

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： MORI KENJI ,  KUZUMAKI NORIYUKI ,  SUGIBAYASHI KENJI ,  MORIMOTO KAZUTOSHI

IPC: A61N1/30

Abstract: PROBLEM TO BE SOLVED: To make it possible to dose sufficient drugs to the skin and mucous membrane even if these drugs are large in required dosage or are low in the absorption from the skin and the mucous membranes by making combination use of electroporation and pulse depolarization type iontophoresis for the skin or the mucous membranes. SOLUTION: A high voltage is first impressed by applying the first time of the electroporation A1 before the application of the iontophoresis. In succession thereto, the iontophoresis operation by the pulse depolarization type energization is applied for a prescribed period and thereafter, the high voltage by the second time of the electroporation A2 is impressed. These operations are successively repeated at need, by which the dosage is executed. The iontophoresis by the pulse depolarization type energization is used in combination, by which the drugs are extremely effectively transmitted from the holes formed by applying the electroporation.

公开(公告)号：JP2002080374A

公开(公告)日：2002-03-19

申请号：JP2000268063

申请日：2000-09-05

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： SUGIBAYASHI KENJI ,  NAKAMURA KATSUHIRO ,  MORIYAMA KAZUAKI

IPC: A61K47/02 ,  A61K33/08 ,  A61K45/00 ,  A61P17/00 ,  A61P17/02 ,  A61P31/00 ,  A61P31/02

Abstract: PROBLEM TO BE SOLVED: To find both a new action of alkali ion water which can sufficiently secure a hydroxide ion and stably maintain a high pH for a fixed period of time or longer and a new use based on the action, especially to obtain a medicine composition, a skin care preparation, a percutaneous absorption promoter and a carrier for a medicine for application to mammals (human, dog, cat, cattle, horse, sheep, pig, etc.), containing such alkali water. SOLUTION: This medicine composition useful as an antimicrobial/germicidal agent, a disinfectant, a wound/sore pressure therapeutic agent, etc., for application to mamals, this skin care preparation for application to mammals, this percutaneous absorption promoter for application to mammals, this carrier for a medicine for application to mammals contain alkali ion water which has pH 11.5-13.0 and stably maintains a pH value at 25 deg.C environment for at least 30 days.

公开(公告)号：AU2003220956A1

公开(公告)日：2003-10-20

申请号：AU2003220956

申请日：2003-03-28

Applicant: HISAMITSU PHARMACEUTICAL CO

Inventor： MORI KENJI ,  HIGO NARUHITO ,  TOKUMOTO SEIJI ,  SATO SHUJI ,  SUGIBAYASHI KENJI

IPC: A61K9/08 ,  A61K9/10 ,  A61K38/28 ,  A61K47/32 ,  A61K47/36 ,  A61M1/36 ,  A61N1/30 ,  A61N1/32 ,  A61P3/10

Abstract: The present invention provides an insulin-administering device enabling the effective administration of insulin via a percutaneous or submucous administration route. The present device is used to percutaneously or transmucosally administer an insulin lispro represented by the structural formula indicated below, or a pharmaceutically acceptable salt thereof, using iontophoresis and electroporation.