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    PROCESS FOR THE PREPARATION OF CORTICOID 17-(ALKYL CATBONATES)
    1.
    发明授权
    PROCESS FOR THE PREPARATION OF CORTICOID 17-(ALKYL CATBONATES) 失效

    公开(公告)号：KR810000582B1

    公开(公告)日：1981-06-03

    申请号：KR780000972

    申请日：1978-04-06

    Applicant: HOECHST AG

    Inventor： FRITSCH W ,  STACH U ,  ALPERMANN H

    IPC: C07J71/00

    Abstract: Corticoid 17-(alkylcarbonates) (I; A = CH2, CH(OH), C=O, C(OH)H; Y = H, F, Cl; Z = H, Cl, F, methyl; R1 = H, acyl, carbonyloxyalkyl, aliphatic or aromatic sulfonic ester; R2 = C1-8 alkyl; R3 = H, or -position methy1, F), useful as antiphlogistic agent, were prepd. by reaction of compd.(III) and carboxylic halide at 21-position. The intermediate.(III) was prepd. by hydrolysis of compd.(II).

    Aminothiophene-carboxylic acid esters
    6.
    发明授权
    Aminothiophene-carboxylic acid esters 失效
    氨基酸 - 羧酸酯

    公开(公告)号：US3795681A

    公开(公告)日：1974-03-05

    申请号：US3795681D

    申请日：1972-05-26

    Applicant: HOECHST AG

    Inventor： RUSCHIG H ,  MEIXNER W ,  ALPERMANN H

    IPC: C07D333/38 ,  A61K27/00 ,  C07D63/16

    CPC classification number: C07D333/38 ,  Y10S514/916

    Abstract: NOVEL AMINOTHIOPHENE-CARBOXYLIC ACID ESTERS ARE DESCRIBED AS WELL AS A PROCESS FOR THEIR MANUFACTURE AND THEIR ANTIPHLOGISTIC AND ANTIPYRETIC ACTION. THE NOVEL COMPOUNDS CORRESPOND TO THE FORMULA I

    2-R1,3-(R-NH-),4-(R4-COO-CH(-R3)-OOC-),5-R2-THIOPHENE

    WHEREIN R REPRESENTS PHENYL WHICH MAY CARRY 1, 2 OR 3 SUBSTITUENTS SELECTED FROM HALOGEN, TRIFLUOROMETHYL, LOW MOLECULAR ALKYL AND ALKOXY, ARALKOXY BEING LOW MOLECULAR IN THE ALKYLENE MOIETY, AND CYCLOALKYL HAVING 5-6 MEMBERS, AND WHEREIN TWO VICINAL SUBSTITUENTS MAY BE MEMBERS OF A CONDENSED ALICYCLIC RING SYSTEM, AND WHEREIN R1 AND R2 EACH REPRESENTS HYDROGEN OR LOW MOLECULAR ALKYL, R3 REPRESENTS HYDROGEN OR LOW MOLECULAR ALKYL AND R4 REPRESENTS ALKYL OR ARYL IN WHICH CASE THE ARYL GROUP MAY CONTAIN 1 OR 2 HETERO ATOMS, SUCH AS NITROGEN, OXYGEN OR SULFUR.

    NEW PEPTIDE AMIDES AND PROCESS FOR THEIR MANUFACTURE
    9.
    发明专利
    NEW PEPTIDE AMIDES AND PROCESS FOR THEIR MANUFACTURE 未知

    公开(公告)号：ZA805151B

    公开(公告)日：1981-08-26

    申请号：ZA805151

    申请日：1980-08-21

    Applicant: HOECHST AG

    Inventor： BICKEL M ,  GEIGER R ,  TEETZ V ,  ALPERMANN H

    IPC: A61K38/00 ,  C07K5/08 ,  A61P25/04 ,  C07K5/087 ,  C07K5/10 ,  C07K5/107 ,  C07K7/06 ,  C07K14/70 ,  C07C

    Abstract: New peptide amides of the formula I H-Tyr-D-Lys(For)-Gly-X (I) wherein For is formyl, X is alkylamino, dehydro-Phe or Phe-alkylamido having up to 6 carbon atoms in the alkyl moiety, which moiety may be substituted by hydroxy and/or phenyl, Phe-cycloalkylamide or Phe-cycloalkylene amide having up to 8 carbon atoms in the cycloalkyl or cyclalkylene moiety, 1 to 2 CH2 groups being optionally replaced by -NH-, -O-, -S- or -CO-, Phe-alkylene-cycloalkylamide having from 5 to 6 ring carbon atoms, which amide may be substituted by carbonamido,N-alkylcarbonamido or alkyl and 1 carbon atom whereof may be replaced by nitrogen, Phe-endo- or exo-norbornylamide or Phe-thiazolamide or Phe-thiazolidine-carboxylic acid amide, which may be substituted by 1 to 4 methyl groups each, and process for their manufacture are disclosed. These peptide amides are distinguished by an analgetic activity and suppress the motility of the ileum of the guinea pig.

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