公开(公告)号：NZ223336A

公开(公告)日：1989-09-27

申请号：NZ22333688

申请日：1988-01-28

Applicant: HOECHST AG

Inventor： WOLF E ,  ROSSMANITH E ,  BARTLETT R R ,  SCHLEYERBACH R

IPC: A61K31/55 ,  A61P29/00 ,  A61P37/00 ,  C07D243/08

Abstract: 1-(4-Hydroxy-3,5-di-tert.-butylbenzoyl)homopiperazine and various derivatives thereof substituted on the nitrogen are prepared starting from 4-hydroxy-3,5-di-tert.-butylbenzoic acid or its derivatives and homopiperazine or appropriate derivatives thereof. The compounds and their physiologically tolerated acid addition salts are suitable for the treatment of inflammatory and painful, in particular inflammatory rheumatic, disorders.

公开(公告)号：NZ223333A

公开(公告)日：1989-08-29

申请号：NZ22333388

申请日：1988-01-28

Applicant: HOECHST AG

Inventor： THORWART W ,  GERBERT U ,  SCHLEYERBACH R ,  BARTLETT R R

IPC: A61K31/53 ,  A61P29/00 ,  C07D253/06 ,  C07D253/075 ,  C07D285/16 ,  C07D513/04

Abstract: Novel substituted 3-phenyl-7H-thiazolo[3,2-b][1,2,4]-triazin-7-ones of the formula I are disclosed (I) in which R1, R2 and R3 have the meaning recited in the specification. The compounds are suitable for prevention and treatment of inflammatory disorders.

公开(公告)号：NZ223334A

公开(公告)日：1989-08-29

申请号：NZ22333488

申请日：1988-01-28

Applicant: HOECHST AG

Inventor： THORWART W ,  GEBERT U ,  SCHLEYERBACH R ,  BARTLETT R R

IPC: A61K31/54 ,  A61P29/00 ,  A61P37/00 ,  C07D233/54 ,  C07D233/84 ,  C07D233/86 ,  C07D513/04

Abstract: Imidazo- and triazolothiadiazines of the formula I … … in which R = C1-C4-alkyl,… R = H or C1-C3-alkyl… and the structural element -A-B-… = -CH2-CH2-, -CH=CH-, -CH=N-, -CH2-CO- or -CO-CH2-,… and their physiologically tolerable acid addition salts are prepared by reaction of 2-halo-1-phenylalkanones of the formula II … … with compounds of the formula III … … and, if desired, conversion of the compounds of the formula I formed into their physiologically tolerable acid addition salts by means of suitable acids. … The compounds of the formula I and their physiologically tolerable acid addition salts are mainly suitable for the prevention and treatment of inflammatory diseases - in particular of inflammatory rheumatic diseases. … Some of the intermediates formed during the preparation of the compounds of the formula I are also new, i.e. 1-amino- 2-mercaptoimidazole … … and 1-amino-2-thioxo-5-imidazolidinone … …

公开(公告)号：NZ223335A

公开(公告)日：1989-09-27

申请号：NZ22333588

申请日：1988-01-28

Applicant: HOECHST AG

Inventor： THORWART W ,  GEBERT U ,  SCHLEYERBACH R ,  BARTLETT R R

IPC: A61K31/54 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07D285/16 ,  C07D417/04

Abstract: Novel 5-(3-alkyl-5-tert.butyl-4-hydroxyphenyl)-2-amino-6H-1,3,4-thiadiazines of the general formula I (I) in which R1=C1-C4-alkyl, R2=H or C1-C3-alkyl R3 and R4=independently of one another, optionally substituted and optionally O- or S-interrupted alkyl, alkenyl or alkynyl groups, it being possible for one of the two radicals to also be H, or R3+R4 together with the nitrogen atom to which they are bound, may denote an optionally substituted 4- to 7-membered ring which optionally contains a further heteroatom (O, S or N), and the physiologically acceptable acid-addition salts thereof. The compounds are primarily suitable for prevention and treatment of inflammatory-in particular inflammatory rheumatic-disorders and/or pain.

公开(公告)号：NZ218359A

公开(公告)日：1989-05-29

申请号：NZ21835986

申请日：1986-11-21

Applicant: HOECHST AG

Inventor： ELBEN V ,  ANAGNOSTOPULOS H ,  BARTLETT R R

IPC: A61K31/44 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/495 ,  A61P37/08 ,  C07D213/74 ,  C07D213/80 ,  C07D213/85 ,  C07D213/89 ,  C07D401/12 ,  C07D401/06 ,  C07D241/04 ,  C07D401/14