公开(公告)号：KR780000099B1

公开(公告)日：1978-01-08

申请号：KR730001924

申请日：1973-11-17

Applicant: HOECHST AG

Inventor： WISSMANN H ,  SCHLEYERBACH R ,  GEIGER R

公开(公告)号：US3749774A

公开(公告)日：1973-07-31

申请号：US3749774D

申请日：1972-01-27

Applicant: HOECHST AG

Inventor： SCHLEYERBACH R ,  GEIGER R

IPC: A61K9/00 ,  A61K27/00

CPC classification number: A61K9/0019

Abstract: SECRETIN PREPARATIION HAVING PROLOGNED ACTION WHICH COMPRISES A CONTENT OF (A) SECRETIN (B) AN AQUEOUS SOLUTION OF GELATIN-DRIVATIVE CROSS-LINKED WITH HEXAMETHYLENE-DIISOCYANATE AND (C) POLYPHLORETIN PHOSPHATE AND A PROCESS FOR THE MANUFACTURE THEREOF.

公开(公告)号：KR820002229B1

公开(公告)日：1982-12-03

申请号：KR790002933

申请日：1979-08-28

Applicant: HOECHST AG

Inventor： KAEMMERER F ,  SCHLEYERBACH R

IPC: A61K31/42 ,  C07D261/18

Abstract: The antipyretic, analgesic and antiinflammatory compd. I was prepd. by the reaction of 4-trifluoromethylaniline II with 5-methylisoxazole-4-carboxylic acid derivatives III (X = halogen atom, YO or ZO-CO-O group, where, Y=phenyl substituted with fluorine, chlorine, bromine, Iodine, methoxy, ethoxy, nitro or cyano. Z=1-4 carbon number alkyl, phenyl or benzyl.

公开(公告)号：KR800001182B1

公开(公告)日：1980-10-20

申请号：KR770002797

申请日：1977-12-01

Applicant: HOECHST AG

Inventor： HEUBACH G ,  KAEMMERER F ,  SCHLEYERBACH R

IPC: C07D261/10

Abstract: Isoxazole derivs. I; R = mono-, di- or tri-nuclear unsaturated heterocyclic group having C and hetero atom in a ring sub- or unsubstituted by alkyl, alkoxy, halogen, nitro, hydroxyl, carbamoyl; X = halogen, YO group or ZO-CO-O group, Y = halogen, methyl, methoxy, trifluoromethylm nitro, cyano substituted or unsaturated phenyl; Z = C1-4 alkyl, benzyl or phenyl were manufd. by reaction of 5-methyl-isoxazol-4-carboxylic acid derivs. II with unsaturated heterocyclic amine III.

公开(公告)号：NZ223333A

公开(公告)日：1989-08-29

申请号：NZ22333388

申请日：1988-01-28

Applicant: HOECHST AG

Inventor： THORWART W ,  GERBERT U ,  SCHLEYERBACH R ,  BARTLETT R R

IPC: A61K31/53 ,  A61P29/00 ,  C07D253/06 ,  C07D253/075 ,  C07D285/16 ,  C07D513/04

Abstract: Novel substituted 3-phenyl-7H-thiazolo[3,2-b][1,2,4]-triazin-7-ones of the formula I are disclosed (I) in which R1, R2 and R3 have the meaning recited in the specification. The compounds are suitable for prevention and treatment of inflammatory disorders.

公开(公告)号：DK534079A

公开(公告)日：1980-06-17

申请号：DK534079

申请日：1979-12-14

Applicant: HOECHST AG

Inventor： KAEMMERER F J ,  SCHLEYERBACH R

IPC: A61K31/42 ,  A61K31/44 ,  A61K31/4418 ,  A61P29/00 ,  C07C235/76 ,  C07D213/30 ,  C07D213/73 ,  C07D213/75 ,  C07D261/18 ,  C07D413/12 ,  C07D

公开(公告)号：NZ223335A

公开(公告)日：1989-09-27

申请号：NZ22333588

申请日：1988-01-28

Applicant: HOECHST AG

Inventor： THORWART W ,  GEBERT U ,  SCHLEYERBACH R ,  BARTLETT R R

IPC: A61K31/54 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07D285/16 ,  C07D417/04

Abstract: Novel 5-(3-alkyl-5-tert.butyl-4-hydroxyphenyl)-2-amino-6H-1,3,4-thiadiazines of the general formula I (I) in which R1=C1-C4-alkyl, R2=H or C1-C3-alkyl R3 and R4=independently of one another, optionally substituted and optionally O- or S-interrupted alkyl, alkenyl or alkynyl groups, it being possible for one of the two radicals to also be H, or R3+R4 together with the nitrogen atom to which they are bound, may denote an optionally substituted 4- to 7-membered ring which optionally contains a further heteroatom (O, S or N), and the physiologically acceptable acid-addition salts thereof. The compounds are primarily suitable for prevention and treatment of inflammatory-in particular inflammatory rheumatic-disorders and/or pain.

公开(公告)号：NZ211139A

公开(公告)日：1988-04-29

申请号：NZ21113985

申请日：1985-02-15

Applicant: HOECHST AG

Inventor： KAMMERER F-J ,  SCHLEYERBACH R

IPC: A61K31/42 ,  A61K31/445 ,  A61K31/535 ,  A61K31/5377 ,  A61K31/54 ,  A61P25/04 ,  C07D261/10 ,  A61P29/00 ,  C07D261/18 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06

Abstract: 4-Isoxazolecarboxylic acid amides of the general formula I (I) in which R denotes hydrogen, alkyl with up to 4 carbon atoms or halogenoalkyl with up to 2 carbon atoms and W denotes a direct bond, CH2, CH-CH3, CH-C2H5, CHOH, O or S, processes for their preparation, medicaments which contain these compounds and the use of the compounds for the treatment of pain and/or fever.

公开(公告)号：NZ192400A

公开(公告)日：1982-02-23

申请号：NZ19240079

申请日：1979-12-14

Applicant: HOECHST AG

Inventor： KAMMERER F ,  SCHLEYERBACH R

IPC: A61K31/42 ,  A61P25/00 ,  A61P29/00 ,  A61P37/08 ,  C07D261/18

Abstract: 5-Methylisoxazole-4-carboxylic acid-(4-trifluoromethyl)-anilide and a process for its preparation is described. The compound has an antirheumatic, antiphlogistic, antipyretic and analgesic action, and can be used for the treatment of multiple sclerosis.

公开(公告)号：NZ223336A

公开(公告)日：1989-09-27

申请号：NZ22333688

申请日：1988-01-28

Applicant: HOECHST AG

Inventor： WOLF E ,  ROSSMANITH E ,  BARTLETT R R ,  SCHLEYERBACH R

IPC: A61K31/55 ,  A61P29/00 ,  A61P37/00 ,  C07D243/08

Abstract: 1-(4-Hydroxy-3,5-di-tert.-butylbenzoyl)homopiperazine and various derivatives thereof substituted on the nitrogen are prepared starting from 4-hydroxy-3,5-di-tert.-butylbenzoic acid or its derivatives and homopiperazine or appropriate derivatives thereof. The compounds and their physiologically tolerated acid addition salts are suitable for the treatment of inflammatory and painful, in particular inflammatory rheumatic, disorders.