公开(公告)号：DK575277A

公开(公告)日：1978-06-25

申请号：DK575277

申请日：1977-12-22

Applicant: HOECHST AG

Inventor： GEBERT U ,  THORWART W ,  KOMAREK J ,  CATHEUSER C ,  POPENDIKER K ,  GREVE H G

IPC: C07D295/08 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/451 ,  A61K31/455 ,  A61K31/495 ,  A61K31/52 ,  A61K31/522 ,  A61P7/10 ,  A61P9/08 ,  A61P9/12 ,  A61P25/02 ,  A61P25/20 ,  C07D209/14 ,  C07D211/22 ,  C07D213/53 ,  C07D213/80 ,  C07D231/16 ,  C07D231/38 ,  C07D233/54 ,  C07D233/64 ,  C07D295/088 ,  C07D303/12 ,  C07D311/22 ,  C07D317/58 ,  C07D317/62 ,  C07D317/64 ,  C07D333/22 ,  C07D473/12 ,  C07D

Abstract: Compounds of general formula (I) wherein R1 represents a radical selected from the group consisting of (a) hydrogen, carboxyl; (b) alkyl, alkenyl each having up to 6 carbon atoms and their phenyl substituted derivatives; (c) at most binuclear unsubstituted aryl, at most binuclear aryl substituted by from 1 to 3 substituents selected from the group consisting of alkyl and alkoxy each having up to 6 carbon atoms, benzloxy, haloalkyl having up to 2 carbon atoms, halogen, cyano and nitro; amino, carboxyl and hydroxy; amino, carboxyl and hydroxy each being substituted by alkyl having at most 2 carbon atoms, methylenedioxy groups and O- -hydroximinom ethyl groups; (d) at most bicyclic unsubstituted heteroaromatic group having 1 to 4 heteroatoms selected from the group consisting of nitrogen, one sulphur and one oxygen in the ring system and such a heteroaromatic group being substituted by at most 3 substituents selected from the group consisting of alkyl, alkoxy each having up to 2 carbon atoms, phenylalkyl having up to 3 carbon atoms in the alkyl moiety, halogen, methylamino and dimethylamino; R2 represents a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, cycloalkyl having up to 6 carbon atoms and phenyl; and R1 and R2, together with the carbon atom to which they are attached, form a radical selected from the group consisting of fluorene-9-ylidene and a cycloaliphatic group having up to 10 carbon atoms and such a cycloaliphatic group containing a hydrocarbon bridging group; R3 represents a member selected from the group consisting of hydrogen hydroxy and acyloxy; R4 represents a member selected from the group consisting of hydrogen alkyl having up to 3 carbon atoms and phenyl; R5 represents a member selected from the group consisting of halogen, alkoxy having up to 2 carbon atoms and hydroxy; and X represents a member selected from the group consisting of nitrogen and methine and physiologically acceptable acid addition salts thereof; a pharmaceutical composition containing said compounds.