公开(公告)号：ZA937141B

公开(公告)日：1994-05-18

申请号：ZA937141

申请日：1993-09-27

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH MATIORAM ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  SANKAR CHINNAKULANDAI ,  SCHOLZ WOLFGANG

IPC: A61K31/472 ,  A61P9/00 ,  A61K31/47 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12 ,  C07D ,  A61K

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：NO180374C

公开(公告)日：1997-04-09

申请号：NO933450

申请日：1993-09-27

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH MATIORAM ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  SCHOLZ WOLFGANG

IPC: A61K31/472 ,  A61P9/00 ,  A61K31/47 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：FI934185A

公开(公告)日：1994-03-29

申请号：FI934185

申请日：1993-09-24

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH MATIORAM ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  SCHOLZ WOLFGANG

IPC: A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61K31/47 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：FI103884B1

公开(公告)日：1999-10-15

申请号：FI934185

申请日：1993-09-24

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH MATIORAM ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  SCHOLZ WOLFGANG

IPC: A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61K31/47 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：NO933450A

公开(公告)日：1994-03-29

申请号：NO933450

申请日：1993-09-27

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH MATIORAM ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH CHRISTIAN ,  SCHOLZ WOLFGANG

IPC: A61K31/47 ,  A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

CPC classification number: C07D401/04 ,  C07D217/26 ,  C07D413/04

公开(公告)号：ZA9307141B

公开(公告)日：1994-05-18

申请号：ZA9307141

申请日：1993-09-27

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH MATIORAM ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  SCHOLZ WOLFGANG

IPC: A61K31/47 ,  A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12 ,  C07D ,  A61K

CPC classification number: C07D401/04 ,  C07D217/26 ,  C07D413/04

公开(公告)号：NO933450L

公开(公告)日：1994-03-29

申请号：NO933450

申请日：1993-09-27

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH MATIORAM ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH CHRISTIAN ,  SCHOLZ WOLFGANG

IPC: A61K31/472 ,  A61P9/00 ,  A61K31/47 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：NO933450D0

公开(公告)日：1993-09-27

申请号：NO933450

申请日：1993-09-27

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH MATIORAM ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  SCHOLZ WOLFGANG

IPC: A61K31/472 ,  A61K31/47 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12 ,  C07D

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：FI934185A0

公开(公告)日：1993-09-24

申请号：FI934185

申请日：1993-09-24

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH MATIORAM ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  SCHOLZ WOLFGANG

IPC: A61K31/47 ,  A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12

Abstract: Described are guanidinocarbonyl isoquinolines I, with R(1) hydrogen, (amino)(cyclo)(aryl)alk(en)yl, (heteroaryl); R(2) hydrogen, halogen, alkyl, or Aryl; G X(2), X(3) and X(4) hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono)(di)(lower alkyl)(amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also the process for their prepara-tion, their use as medicaments, and medicaments containing them for treating congestive heart failure, arrhythmic conditions as well as cardioprotective agents in mammals.

公开(公告)号：FI103884B

公开(公告)日：1999-10-15

申请号：FI934185

申请日：1993-09-24

Applicant: HOECHST AG

Inventor： LAL BANSI ,  GIDWANI RAMESH MATIORAM ,  RAJAGOPALAN RAMANUJAM ,  PANICKER RADHA ,  SANKAR CHINNAKULANDAI ,  LANG HANS-JOCHEN ,  ENGLERT HEINRICH ,  SCHOLZ WOLFGANG

IPC: A61K31/472 ,  A61P9/00 ,  A61P9/04 ,  A61K31/47 ,  A61P9/06 ,  A61P9/10 ,  C07D217/26 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12