公开(公告)号：JPH10204099A

公开(公告)日：1998-08-04

申请号：JP34263197

申请日：1997-12-12

Applicant: HOECHST AG

Inventor： VERTESY LASZLO ,  KNAUF MARTIN ,  WINK JOACHIM ,  ISERT DIETER ,  STAHL WILHELM ,  RIESS GUNTHER ,  ASZODI JOZSEF ,  BELLER DOMINIQUE LE

IPC: C12P1/06 ,  A61K38/00 ,  A61K38/10 ,  A61P31/00 ,  C07K7/08 ,  C12N1/20 ,  C12P21/02 ,  C12R1/465 ,  C12R1/645

Abstract: PROBLEM TO BE SOLVED: To provide the subject new non-toxic substance produced by a specific microorganism of the genus Streptomyces, active as an antibiotic substance, having high tolerance and effectively inhibiting human immunodeficiency virus. SOLUTION: This substance is a compound of the formula, its salt or its chemically equivalent substance. It has the following properties. Appearance, colorless; solubility, soluble in methanol, acetonitrile and water; stability, stable under neutral or moderately alkaline conditions and unstable in strongly acidic or strongly alkaline solution; molecular formula, C95 H97 N13 O30 ; molecular weight, 1900.90; etc. The compound can be produced by the fermentation with a microorganism HAG 4674 (DSM 11171) of the genus Streptomyces, its variant or mutant. The fermentation is preferably carried out in a nutrient solution containing 1-2% of oat flake and a minor element solution of 0.2-0.3% concentration under aerobic condition at 25-30 deg.C and pH5.5-8.5 for 24-140hr.

公开(公告)号：HK1011971A1

公开(公告)日：1999-07-23

申请号：HK98113024

申请日：1998-12-09

Applicant: HOECHST AG

Inventor： BILLHARDT UTA-MARIA ,  ROSNER MANFRED ,  RIESS GUNTHER ,  WINKLER IRVIN ,  BENDER RUDOLF

IPC: A61K31/495 ,  A61K20060101 ,  A61K31/535 ,  A61K31/54 ,  A61P31/12 ,  A61P31/16 ,  A61P31/18 ,  C07D20060101 ,  C07D241/38 ,  C07D241/40 ,  C07D241/44 ,  C07D241/52 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D471/04 ,  C07D487/04 ,  C07D ,  A61K

Abstract: Compounds of the formula I or Ia in which n and the substituents R - R and also X have the same meaning, have antiviral activity.

公开(公告)号：AU693482B2

公开(公告)日：1998-07-02

申请号：AU7908694

申请日：1994-11-28

Applicant: HOECHST AG

Inventor： RIESS GUNTHER ,  SEIBERT GERHARD ,  HEDTMANN UDO

IPC: C07H11/04 ,  A61K31/70 ,  A61K45/06 ,  A61P1/04 ,  A61K31/71

Abstract: Moenomycin and its derivatives are suitable for preparation of medicaments for the treatment of stomach ulcers and for the control of Helicobacter pylori.

公开(公告)号：AU2291297A

公开(公告)日：1997-10-29

申请号：AU2291297

申请日：1997-03-25

Applicant: HOECHST AG

Inventor： KIRSCH REINHARD ,  KLEIM JORG-PETER ,  RIESS GUNTHER ,  ROSENSTOCK BERND ,  ROSNER MANFRED ,  WINKLER IRVIN

IPC: A61K31/00 ,  A61K31/47 ,  A61K31/4704 ,  A61K31/4709 ,  A61P31/00 ,  A61P31/12 ,  C07D215/22 ,  C07D215/227 ,  C07D215/50 ,  C07D401/12 ,  C07D491/04 ,  C07D491/06

Abstract: PCT No. PCT/EP97/01496 Sec. 371 Date Mar. 3, 1999 Sec. 102(e) Date Mar. 3, 1999 PCT Filed Mar. 25, 1997 PCT Pub. No. WO97/37977 PCT Pub. Date Oct. 16, 1997Substituted quinoline derivatives, processes for their preparation, and their use. Compounds of the formula I and their tautomeric forms, of the formula Ia in which m, n and the substituents X and R1 to R5 have the meanings mentioned, have an action against viruses.

公开(公告)号：NZ242346A

公开(公告)日：1994-12-22

申请号：NZ24234692

申请日：1992-04-13

Applicant: HOECHST AG

Inventor： BILLHARDT UTA-MARIA ,  ROSNER MANFRED ,  RIESS GUNTHER ,  WINKLER IRVIN ,  BENDER RUDOLF

IPC: A61K31/495 ,  A61K20060101 ,  A61K31/535 ,  A61K31/54 ,  A61P31/12 ,  A61P31/16 ,  A61P31/18 ,  C07D20060101 ,  C07D241/38 ,  C07D241/40 ,  C07D241/44 ,  C07D241/52 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D471/04 ,  C07D487/04 ,  C07D241/50 ,  C07D413/04

Abstract: Compounds of the formula I or Ia in which n and the substituents R - R and also X have the same meaning, have antiviral activity.

公开(公告)号：NZ237882A

公开(公告)日：1993-12-23

申请号：NZ23788291

申请日：1991-04-19

Applicant: HOECHST AG

Inventor： KOLLER KLAUS-PETER ,  RIESS GUNTHER

IPC: C07K14/195 ,  C07K14/005 ,  C07K14/36 ,  C07K14/575 ,  C07K14/62 ,  C07K19/00 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/17 ,  C12N15/62 ,  C12N15/76 ,  C12P21/02 ,  C12R1/465

Abstract: Gene structures which code for the signal sequence and approximately the first ten amino acids of tendamistat as well as a required protein are expressed in high yield in streptomyces host cells, and the fusion proteins are secreted into the medium.

公开(公告)号：AU738970B2

公开(公告)日：2001-10-04

申请号：AU4835997

申请日：1997-12-12

Applicant: HOECHST AG

Inventor： VERTESY LASZLO ,  KNAUF MARTIN ,  WINK JOACHIM ,  ISERT DIETER ,  STAHL WILHELM ,  RIESS GUNTHER ,  ASZODI JOZSEF ,  BELLER DOMINIQUE LE

IPC: C12P1/06 ,  A61K38/00 ,  A61K38/10 ,  A61P31/00 ,  C07K7/08 ,  C12N1/20 ,  C12P21/02 ,  C12R1/465 ,  C12R1/645 ,  A61K31/195

Abstract: The tridecapeptide of formula (I), designated 'feglymycin', and its salts and chemical equivalents are new. Mpg-Dpg-Val-Dpg-Mpg-Dpg-Mpg-Dpg-Val-Dpg-Mpg-Phe-Asp (I) Mpg = 4-hydroxyphenylglycine residue; Dpg = 3,5-dihydroxyphenylglycine residue. Also new is the microorganism Streptomyces species DSM 11171.

公开(公告)号：HK1011988A1

公开(公告)日：1999-07-23

申请号：HK98113241

申请日：1998-12-12

Applicant: HOECHST AG

Inventor： ROSNER MANFRED ,  BILLHARDT-TROUGHTON UTA-MARIA ,  KIRSCH REINHARD ,  KLEIM JORG-PETER ,  MEICHSNER CHRISTOPH ,  RIESS GUNTHER ,  WINKLER IRVIN

IPC: A61K31/495 ,  A61P31/12 ,  C07D241/44 ,  C07F11/00 ,  C07D ,  A61K

Abstract: Quinoxaline derivs. of formula (I) and tautomers of formula (Ia), and their salts and prodrugs are new: R1 = F, Cl,OH or 1-3C alkoxy; R2 = 1-4C alkyl (opt. substd. by OH, 1-4C alkoxy or 1-4C alkylthio); R3 = 1-6C alkoxy-carbonyl or 2-6C alkenyloxy carbonyl; X = 0, S or Se; n = 0-2.

公开(公告)号：AU4835997A

公开(公告)日：1998-06-18

申请号：AU4835997

申请日：1997-12-12

Applicant: HOECHST AG

Inventor： VERTESY LASZLO ,  KNAUF MARTIN ,  WINK JOACHIM ,  ISERT DIETER ,  STAHL WILHELM ,  RIESS GUNTHER ,  ASZODI JOZSEF ,  BELLER DOMINIQUE LE

IPC: C12P1/06 ,  A61K38/00 ,  A61K38/10 ,  A61P31/00 ,  C07K7/08 ,  C12N1/20 ,  C12P21/02 ,  C12R1/465 ,  C12R1/645 ,  A61K31/195

Abstract: The tridecapeptide of formula (I), designated 'feglymycin', and its salts and chemical equivalents are new. Mpg-Dpg-Val-Dpg-Mpg-Dpg-Mpg-Dpg-Val-Dpg-Mpg-Phe-Asp (I) Mpg = 4-hydroxyphenylglycine residue; Dpg = 3,5-dihydroxyphenylglycine residue. Also new is the microorganism Streptomyces species DSM 11171.

公开(公告)号：AU5103796A

公开(公告)日：1996-10-16

申请号：AU5103796

申请日：1996-03-08

Applicant: HOECHST AG

Inventor： PEYMAN ANUSCHIRWAN ,  RUPPERT DIETER ,  RIESS GUNTHER

IPC: C07D213/89 ,  A61K31/44