公开(公告)号：SG54274A1

公开(公告)日：1998-11-16

申请号：SG1996006989

申请日：1993-11-12

Applicant: HOECHST AG

Inventor： MEIWES JOHANNES ,  WULLBRANDT DIETER ,  GIANI CARLO

IPC: C12N1/14 ,  C12N9/24 ,  C12P19/14 ,  C12P19/44 ,  C12R1/80

Abstract: The invention relates to alpha -L-rhamnosidase which catalyses the cleavage of the linkage between terminal rhamnose and aglycone of rhamnose-containing glycosides, to a process for the biotechnological preparation and the use thereof for the preparation of L(+)-rhamnose (6-deoxy-L-mannose).

公开(公告)号：LT3328B

公开(公告)日：1995-07-25

申请号：LTIP712

申请日：1993-06-25

Applicant: HOECHST AG

Inventor： DOERSCHUG MICHAEL ,  KOLLER KLAUS PETER ,  MARQUARDT RUEDIGER ,  MEIWES JOHANNES

IPC: C12N9/52 ,  C07K14/62 ,  C12N9/48 ,  C12N15/09 ,  C12P21/02 ,  C12P21/06 ,  C12P21/04

Abstract: A process for the specific hydrolysis of the amino-acid chain of preproinsulins to give the corresponding intermediates with the aid of clostripain is described, and these intermediates can be converted where appropriate with carboxypeptidase B into the corresponding insulins.

公开(公告)号：SK68594A3

公开(公告)日：1995-01-05

申请号：SK68594

申请日：1994-06-06

Applicant: HOECHST AG

Inventor： HAMMANN PETER ,  MEIWES JOHANNES ,  SEIBERT GERHARD ,  VERTESY LASZLO ,  WINK JOACHIM ,  MARKUS ASTRID

IPC: C12P21/02 ,  A61K38/00 ,  A61K38/08 ,  A61K38/12 ,  A61P31/04 ,  C07K20060101 ,  C07K1/20 ,  C07K7/06 ,  C07K7/60 ,  C07K14/195 ,  C07K14/41 ,  C12N1/20 ,  C12P1/06 ,  C12P21/04 ,  C12R1/045

Abstract: Disclosed are lipopeptides with homologal sequencies of amino acids but with different residuals of fatty acids (lipidic part) of general formula (I), wherein R1 is residual one or more times of unsaturated, saturated or independently branched or unbranched fatty acid or hydroxy fatty acid with the length of chain of C6-22 including, which are synthetized during fermentation by bacteria Actionplanes sp. and secreted into the cultivator medium, methods for preparation of these lipopeptides, medicaments containing them and use of these lipopeptides for preparation of antibiotics against gram-positive bacteria. Disclosed are also bacteria Actionplanes sp. DSM 7358 which produce the said lipopeptides.

公开(公告)号：PL303716A1

公开(公告)日：1994-12-12

申请号：PL30371694

申请日：1994-06-06

Applicant: HOECHST AG

Inventor： HAMMANN PETER ,  MEIWES JOHANNES ,  SEIBERT GERHARD ,  VERTESY LASZLO ,  WINK JOACHIM ,  MARKUS ASTRID

IPC: C12P21/02 ,  A61K38/00 ,  A61K38/08 ,  A61K38/12 ,  A61P31/04 ,  C07K20060101 ,  C07K1/20 ,  C07K7/06 ,  C07K7/60 ,  C07K14/195 ,  C07K14/41 ,  C12N1/20 ,  C12P1/06 ,  C12P21/04 ,  C12R1/045 ,  C07K7/50

Abstract: Lipo-peptides of formula (I), where R1 is a saturated or unsaturated, branched or unbranched, 6-22C fatty acid or hydroxy fatty acid residue other than those of formula (II)-(VII), are new:

公开(公告)号：FI942660A

公开(公告)日：1994-12-09

申请号：FI942660

申请日：1994-06-06

Applicant: HOECHST AG

Inventor： HAMMANN PETER ,  MEIWES JOHANNES ,  SEIBERT GERHARD ,  VERTESY LASZLO ,  WINK JOACHIM ,  MARKUS ASTRID

IPC: C12P21/02 ,  A61K38/00 ,  A61K38/08 ,  A61K38/12 ,  A61P31/04 ,  C07K20060101 ,  C07K1/20 ,  C07K7/06 ,  C07K7/60 ,  C07K14/195 ,  C07K14/41 ,  C12N1/20 ,  C12P1/06 ,  C12P21/04 ,  C12R1/045 ,  C07K7/52

Abstract: Lipo-peptides of formula (I), where R1 is a saturated or unsaturated, branched or unbranched, 6-22C fatty acid or hydroxy fatty acid residue other than those of formula (II)-(VII), are new:

公开(公告)号：FI942660A0

公开(公告)日：1994-06-06

申请号：FI942660

申请日：1994-06-06

Applicant: HOECHST AG

Inventor： HAMMANN PETER ,  MEIWES JOHANNES ,  SEIBERT GERHARD ,  VERTESY LASZLO ,  WINK JOACHIM ,  MARKUS ASTRID

IPC: C12P21/02 ,  A61K38/00 ,  A61K38/08 ,  A61K38/12 ,  A61P31/04 ,  C07K20060101 ,  C07K1/20 ,  C07K7/06 ,  C07K7/60 ,  C07K14/195 ,  C07K14/41 ,  C12N1/20 ,  C12P1/06 ,  C12P21/04 ,  C12R1/045 ,  C07K

Abstract: Lipo-peptides of formula (I), where R1 is a saturated or unsaturated, branched or unbranched, 6-22C fatty acid or hydroxy fatty acid residue other than those of formula (II)-(VII), are new:

公开(公告)号：CA2101654A1

公开(公告)日：1994-02-01

申请号：CA2101654

申请日：1993-07-30

Applicant: HOECHST AG

Inventor： KRETZSCHMAR GERHARD ,  MEIWES JOHANNES ,  SCHUDOK MANFRED ,  HAMMANN PETER ,  LERCH ULRICH ,  GRABLEY SUSANNE

IPC: C07D233/64 ,  C07D333/24 ,  C07D333/28 ,  C07D333/42 ,  C07D409/06 ,  C07K1/00 ,  C12P13/04 ,  C12P13/06 ,  C12P17/00 ,  C12R1/01 ,  C12R1/19 ,  C12P21/00 ,  C12P17/16 ,  C07K7/18 ,  C07D333/26

Abstract: 1 Process for the biotechnological preparation of L-thi-enylalanines in enantiomerically pure form from 2hydroxy-3-thienylacrylic acids, and their use L-Thienylalanines are prepared via the hydantoin or the azlactone route. The starting substances used for the biotransformation are 2-hydroxy-3-thienylacrylic acids. The innovative step consists in the transamination of the enol form of the 2-hydroxy-3-thienylacrylic acids to give L-thienylalanines with the aid of biotransformation. The transaminiation is carried out in the presence of L-aspartic acid or L-glutamic acid as amino donor.

公开(公告)号：NO932327D0

公开(公告)日：1993-06-24

申请号：NO932327

申请日：1993-06-24

Applicant: HOECHST AG

Inventor： GIANI CARLO ,  WULLBRANDT DIETER ,  ROTHERT REINHARDT ,  MEIWES JOHANNES

IPC: C12N1/20 ,  C12P19/02 ,  C12P19/12 ,  C12P19/44 ,  C12R1/385 ,  C12N1/00 ,  C12P

Abstract: Bacterial strains are able to produce rhamnolipids which they release into the culture solution. On use of bacteria of the species Pseudomonas aeruginosa for the fermentation, these microorganisms synthesise rhamnolipids in a concentration of 70-120 g/l of culture solution. The L-rhamnose can be isolated from the culture solution directly by hydrolysis of the rhamnolipids, i.e. without an elaborate removal of the biomass and without isolation of the rhamnolipids before the hydrolysis.

公开(公告)号：CA2069199A1

公开(公告)日：1992-11-24

申请号：CA2069199

申请日：1992-05-22

Applicant: HOECHST AG

Inventor： MUELLER WOLFGANG ,  MEIWES JOHANNES ,  SCHUDOK MANFRED

IPC: C07K1/107 ,  C12N9/52 ,  C12P21/02 ,  C12R1/145 ,  C12P21/00

Abstract: HOE 91/F 154 A process for the clostripain-catalyzed linkage of ArgPro and Arg-B (B = proteinogenous and non-proteinogenous amino acids) containing peptides The clostripain obtained from the culture filtrate from Clostridium histolyticum DSM 627 is employed for the linkage of arginine with amino-terminal protection or of peptides with amino-terminal protection and carboxylterminal arginine (acyl donor) to an amino acid or to a peptide with amino donor function. The enzyme can be obtained in high purity by alcohol precipitation and subsequent adsorption of the enzyme obtained from the alcohol-precipitated culture filtrate onto reactive dye and used for the linkage. The specific activity of clostripain is at least 80 U/mg. Clostripain catalyzes not only the abovementioned linkage of proteinogenous amino acids but also the linkage of a proteinogenous to a non-proteinogenous amino acid.

公开(公告)号：ZA9107008B

公开(公告)日：1992-04-29

申请号：ZA9107008

申请日：1991-09-04

Applicant: HOECHST AG

Inventor： DOERSCHUG MICHAEL ,  MICHAEL DOERSCHUG ,  KOLLER KLAUS-PETER ,  KLAUS-PETER KOLLER ,  MARQUARDT RUEDIGER ,  RUEDIGER MARQUARDT ,  MEIWES JOHANNES ,  JOHANNES MEIWES

IPC: C12N9/52 ,  C07K14/62 ,  C12N9/48 ,  C12N15/09 ,  C12P21/02 ,  C12P21/06 ,  C12P ,  C07K

CPC classification number: C12N9/48 ,  C07K14/62