公开(公告)号：JPH10120686A

公开(公告)日：1998-05-12

申请号：JP22225897

申请日：1997-08-19

Applicant: HOECHST AG

Inventor： VERTESY LASZLO ,  KURZ MICHAEL ,  WINK JOACHIM ,  MARKUS ASTRID ,  STAHL WILHELM

IPC: C12P17/18 ,  A61K31/365 ,  A61P31/04 ,  A61P31/10 ,  A61P33/02 ,  C07D493/04 ,  C07H17/08 ,  C12N1/20 ,  C12P19/62 ,  C12R1/465

Abstract: PROBLEM TO BE SOLVED: To obtain a novel polyene antibiotic substances 3874H1 to H6 which are produced by Streptomyces DSM11007 and is useful as an antifungal agent of a therapeutic agent for treatment of diseases relating to increased steroidal concentration. SOLUTION: This novel polyene antibiotic agent is produced by Streptomyces DSM11007 and comprises the following 6 substances: antibiotic substance 3874H1 is represented by formula I, has the molecular formula of C58 H86 N2 O18 and the molecular weight of 1099.3; the antibiotic substance 3874H2 is represented by formula II, has the molecular formula of C59 H88 N2 O18 and the molecular weight of 1113.3; the antibiotic substance 3874H3 is represented by formula III, has the molecular formula of C57 H87 N2 O18 and the molecular weight of 1074.3; the antibiotic substance 3874H4 is represented by formula IV, has the molecular formula of C58 H84 N2 O18 and the molecular weight of 1097.3; the antibiotic substance 3874H5 is represented by formula V, has the molecular formula of C57 H85 N2 O18 and the molecular weight of 1072.3. The agent is useful as an antifungal agent and for treatment of diseases relating to increased steroidalal concentration. These antibiotic substances are obtained by fermentation of Streptomyces DSM11007 or its mutant under appropriate conditions and isolating the products from the culture mixture, respectively.

公开(公告)号：WO9813009A3

公开(公告)日：1998-05-14

申请号：PCT/EP9705070

申请日：1997-09-16

Applicant: HOECHST AG ,  BOHN MANFRED ,  KRAEMER KARL THEODOR ,  MARKUS ASTRID

Inventor： BOHN MANFRED ,  KRAEMER KARL THEODOR ,  MARKUS ASTRID

IPC: A61K8/00 ,  A61K8/49 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4412 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q19/00 ,  A61K7/00

CPC classification number: A61Q5/006 ,  A61K8/4926 ,  A61K31/4412 ,  A61Q5/02 ,  A61Q19/00

Abstract: Compounds of the formula (I) are suitable for the production of pharmaceuticals to treat seborrheic dermatitis.

公开(公告)号：BG64365B1

公开(公告)日：2004-12-30

申请号：BG10326099

申请日：1999-03-17

Applicant: HOECHST AG

Inventor： BOHN MANFRED ,  KRAEMER KARL ,  MARKUS ASTRID

IPC: A61K8/00 ,  A61K8/49 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4412 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q19/00 ,  A61K7/00

Abstract: The invention relates to compounds suitable for the preparation of pharmaceutical preparations for the treatment of seborrheic dermatitis. They have the formula where their substituents have the meanings listed in the description.

公开(公告)号：ES2180774T3

公开(公告)日：2003-02-16

申请号：ES96915016

申请日：1996-05-03

Applicant: HOECHST AG

Inventor： BOHN MANFRED ,  KRAEMER KARL ,  MARKUS ASTRID

IPC: A61K8/00 ,  A61K8/37 ,  A61K8/49 ,  A61K31/4412 ,  A61P31/10 ,  A61Q3/02 ,  A61Q19/00 ,  A61K7/043

Abstract: PCT No. PCT/EP96/01855 Sec. 371 Date Jan. 11, 1999 Sec. 102(e) Date Jan. 11, 1999 PCT Filed May 3, 1996 PCT Pub. No. WO96/36311 PCT Pub. Date Nov. 21, 1996A nail varnish comprising glyceryl triacetate as an active compound and a water-insoluble film-forming agent is suitable for treatment of onychomycoses. If appropriate, the nail varnish can also additionally comprise antimycotic 1-hydroxy-2-pyridone derivatives.

公开(公告)号：BG63589B1

公开(公告)日：2002-06-28

申请号：BG10113897

申请日：1997-01-16

Applicant: HOECHST AG

Inventor： BOHN MANFRED ,  KRAEMER KARL ,  MARKUS ASTRID

IPC: A61K8/00 ,  A61K8/37 ,  A61K8/49 ,  A61K31/4412 ,  A61P31/10 ,  A61Q3/02 ,  A61Q19/00 ,  A61K7/043

Abstract: The invention relates to nail varnish suitable for the treatment of onychomycosis. It contains glyceryltriacetate as an active compound, water insoluble film-forming substance and in a given case antimycotic-acting derivatives of 1-hydroxy-2-pyridon. 5 claims

公开(公告)号：NO312395B1

公开(公告)日：2002-05-06

申请号：NO970198

申请日：1997-01-16

Applicant: HOECHST AG

Inventor： BOHN MANFRED ,  KRAEMER KARL ,  MARKUS ASTRID

IPC: A61K8/00 ,  A61K8/37 ,  A61K8/49 ,  A61K31/4412 ,  A61P31/10 ,  A61Q3/02 ,  A61Q19/00 ,  A61K7/043

Abstract: PCT No. PCT/EP96/01855 Sec. 371 Date Jan. 11, 1999 Sec. 102(e) Date Jan. 11, 1999 PCT Filed May 3, 1996 PCT Pub. No. WO96/36311 PCT Pub. Date Nov. 21, 1996A nail varnish comprising glyceryl triacetate as an active compound and a water-insoluble film-forming agent is suitable for treatment of onychomycoses. If appropriate, the nail varnish can also additionally comprise antimycotic 1-hydroxy-2-pyridone derivatives.

公开(公告)号：SK281830B6

公开(公告)日：2001-08-06

申请号：SK68594

申请日：1994-06-06

Applicant: HOECHST AG

Inventor： HAMMANN PETER ,  MEIWES JOHANNES ,  SEIBERT GERHARD ,  VERTESY LASZLO ,  WINK JOACHIM ,  MARKUS ASTRID

IPC: C12P21/02 ,  A61K38/00 ,  A61K38/08 ,  A61K38/12 ,  A61P31/04 ,  C07K20060101 ,  C07K1/20 ,  C07K7/06 ,  C07K7/60 ,  C07K14/195 ,  C07K14/41 ,  C12N1/20 ,  C12P1/06 ,  C12P21/04 ,  C12R1/045

Abstract: Lipo-peptides of formula (I), where R1 is a saturated or unsaturated, branched or unbranched, 6-22C fatty acid or hydroxy fatty acid residue other than those of formula (II)-(VII), are new:

公开(公告)号：AU721483B2

公开(公告)日：2000-07-06

申请号：AU3423097

申请日：1997-08-18

Applicant: HOECHST AG

Inventor： VERTESY LASZLO ,  KURZ MICHAEL ,  WINK JOACHIM ,  MARKUS ASTRID ,  STAHL WILHELM

IPC: C12P17/18 ,  A61K31/365 ,  A61P31/04 ,  A61P31/10 ,  A61P33/02 ,  C07D493/04 ,  C07H17/08 ,  C12N1/20 ,  C12P19/62 ,  C12R1/465 ,  C07D493/08 ,  C12P17/08 ,  A61K31/71

Abstract: Polyene derivatives of formula (I-VI): their salts and obvious chemical equivalents are new. Molecular formula: (MF) C59H88N2O18 (II), molecular weight (mol. wt.) 1113.3; MF: C57H87NO18 (III), mol. wt. 1074.3; MF: C58H84N2O18 (IV), mol.wt. 1097.3; MF: C59H86N2O18 (V), mol. wt. 1111.3, and MF: C57H85NO18 (VI), mol. wt. 1072.3. X = a group of formula (a) or (b), and Y = CH=CH-CH=CH-Me or a group of formula (c) or (d). Also claimed is the micro-organism Streptomyces DSM 11007.

公开(公告)号：AU716208B2

公开(公告)日：2000-02-24

申请号：AU4774697

申请日：1997-09-16

Applicant: HOECHST AG

Inventor： BOHN MANFRED ,  KRAEMER KARL THEODOR ,  MARKUS ASTRID

IPC: A61K8/00 ,  A61K8/49 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4412 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q19/00 ,  A61K7/00

Abstract: Compounds of the formula (I) are suitable for the production of pharmaceuticals to treat seborrheic dermatitis.

公开(公告)号：BR9711559A

公开(公告)日：1999-08-24

申请号：BR9711559

申请日：1997-09-16

Applicant: HOECHST AG

Inventor： BOHN MANFRED ,  KRAEMER KARL THEODOR ,  MARKUS ASTRID

IPC: A61K9/06 ,  A61K9/00 ,  A61K9/10 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4412 ,  A61K45/08 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38 ,  A61P31/10

Abstract: A pharmaceutical composition comprises a gelling agent, water and a compound of formula (I) or its salts. R1-R3 = H or 1-4C alkyl; and R4 = 6-9C saturated hydrocarbon.