公开(公告)号：DE3237573A1

公开(公告)日：1984-04-12

申请号：DE3237573

申请日：1982-10-09

Applicant: HOECHST AG

Inventor： KLEINER HANS-JOERG DR ,  KLOSS GERHARD DR ,  MOLTER MICHAEL DR ,  SCHWARZ ALEXANDER DR ,  THAMM HELMUT DR

IPC: A61K51/00 ,  A61K51/04 ,  C07F9/38 ,  A61K49/02

Abstract: A diagnostic agent for the visualization of RES-containing organs or of lymph vessels, containing 99mTc triphosphonates or tetraphosphonates in physiologic saline, and a process for their preparation.

公开(公告)号：DE2920174A1

公开(公告)日：1980-11-20

申请号：DE2920174

申请日：1979-05-18

Applicant: HOECHST AG

Inventor： MOLTER MICHAEL DR ,  KLOSS GERHARD DR

IPC: A61K51/00 ,  A61K51/02 ,  A61K51/04 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C237/04 ,  C07F13/00 ,  A61K49/02

Abstract: What are disclosed are (2,3,4,5,6-pentafluoroacetanilido)-iminodiacetic acid and a method for its preparation from chloroacetic acid (2,3,4,5,6-pentafluoroanilide); (4-n-pentylacetanilido)-iminodiacetic acid and a method for its preparation from chloroacetic acid (4-n-pentylanilide); diagnostic agents for visualizing the heptobiliary system containing these substituted acetanilidoiminodiacetic acid compounds labeled with technetium-99m; and methods for making and using such diagnostic agents.

公开(公告)号：DE3234665A1

公开(公告)日：1984-03-22

申请号：DE3234665

申请日：1982-09-18

Applicant: HOECHST AG

Inventor： MOLTER MICHAEL DR ,  PUETTER DIETRICH

IPC: A61K51/04 ,  A61K51/12 ,  A61K49/02

Abstract: Published without abstract.

公开(公告)号：DE3063755D1

公开(公告)日：1983-07-21

申请号：DE3063755

申请日：1980-05-12

Applicant: HOECHST AG

Inventor： MOLTER MICHAEL DR ,  KLOSS GERHARD DR

IPC: A61K51/00 ,  A61K51/02 ,  A61K51/04 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C237/04 ,  C07F13/00 ,  A61K49/02 ,  A61K43/00 ,  C07B23/00 ,  C07C103/375 ,  C07C103/365 ,  C07C103/50

Abstract: What are disclosed are (2,3,4,5,6-pentafluoroacetanilido)-iminodiacetic acid and a method for its preparation from chloroacetic acid (2,3,4,5,6-pentafluoroanilide); (4-n-pentylacetanilido)-iminodiacetic acid and a method for its preparation from chloroacetic acid (4-n-pentylanilide); diagnostic agents for visualizing the heptobiliary system containing these substituted acetanilidoiminodiacetic acid compounds labeled with technetium-99m; and methods for making and using such diagnostic agents.

公开(公告)号：DE2855334A1

公开(公告)日：1980-07-10

申请号：DE2855334

申请日：1978-12-21

Applicant: HOECHST AG

Inventor： MOLTER MICHAEL DR ,  KLOSS GERHARD DR ,  SCHICKEL EBERHARD

IPC: A61K51/00 ,  A61K51/04 ,  C07C103/50 ,  A61K29/00 ,  G01N33/16

公开(公告)号：DE3364983D1

公开(公告)日：1986-09-04

申请号：DE3364983

申请日：1983-10-05

Applicant: HOECHST AG

Inventor： KLEINER HANS-JERG DR ,  KLOSS GERHARD DR ,  MOLTER MICHAEL DR ,  SCHWARZ ALEXANDER DR ,  THAMM HORST-DIETER DR

IPC: A61K51/00 ,  A61K51/04 ,  C07F9/38 ,  A61K49/02

Abstract: A diagnostic agent for the visualization of RES-containing organs or of lymph vessels, containing 99mTc triphosphonates or tetraphosphonates in physiologic saline, and a process for their preparation.

公开(公告)号：DE2860766D1

公开(公告)日：1981-09-17

申请号：DE2860766

申请日：1978-12-23

Applicant: HOECHST AG

Inventor： STRECKER HELMUT DR ,  MOLTER MICHAEL DR ,  KLOSS GERHARD DR ,  SCHICKEL EBERHARD

IPC: A61K51/00 ,  A61K51/04 ,  A61K43/00

Abstract: A process is disclosed for the preparation of a diagnositc agent for scanning the RES, in particular the liver, by mixing the sodium salt of 1-phenyl-2,3-dimethyl-pyrazolone-4-methylamino-methylsulfonic acid or 1-phenyl-2,3-dimethyl-pyrazolone in aqueous solution with tin(II) salt, adjusting the solution to a pH between 4 and 9, optionally lyophilizing the mixture and adding 99mTc-pertechnetate in physiological saline solution.

公开(公告)号：DE2800538A1

公开(公告)日：1979-07-19

申请号：DE2800538

申请日：1978-01-07

Applicant: HOECHST AG

Inventor： STRECKER HELMUT DR ,  MOLTER MICHAEL DR ,  KLOSS GERHARD DR ,  SCHICKEL EBERHARD

IPC: A61K51/00 ,  A61K51/04 ,  A61K29/00

Abstract: A process is disclosed for the preparation of a diagnositc agent for scanning the RES, in particular the liver, by mixing the sodium salt of 1-phenyl-2,3-dimethyl-pyrazolone-4-methylamino-methylsulfonic acid or 1-phenyl-2,3-dimethyl-pyrazolone in aqueous solution with tin(II) salt, adjusting the solution to a pH between 4 and 9, optionally lyophilizing the mixture and adding 99mTc-pertechnetate in physiological saline solution.

公开(公告)号：AT21034T

公开(公告)日：1986-08-15

申请号：AT83109937

申请日：1983-10-05

Applicant: HOECHST AG

Inventor： KLEINER HANS-JERG DR ,  KLOSS GERHARD DR ,  MOLTER MICHAEL DR ,  SCHWARZ ALEXANDER DR ,  THAMM HORST-DIETER DR

IPC: A61K51/00 ,  A61K51/04 ,  C07F9/38 ,  A61K49/02

公开(公告)号：DE2966518D1

公开(公告)日：1984-02-02

申请号：DE2966518

申请日：1979-12-17

Applicant: HOECHST AG

Inventor： MOLTER MICHAEL DR ,  KLOSS GERHARD DR ,  SCHICKEL EBERHARD

IPC: A61K51/00 ,  A61K51/04 ,  A61K49/02 ,  C07C103/50