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    INOSITOL GLUCAN HAVING INSULIN-LIKE ACTIVITY
    2.
    发明专利
    INOSITOL GLUCAN HAVING INSULIN-LIKE ACTIVITY 失效

    公开(公告)号：JPH10158291A

    公开(公告)日：1998-06-16

    申请号：JP32550897

    申请日：1997-11-27

    Applicant: HOECHST AG

    Inventor： FRICK WENDELIN DR ,  MUELLER GUENTER DR

    IPC: C07H15/207 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/715 ,  A61K31/716 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P5/00 ,  A61P5/48 ,  C07H3/04 ,  C07H3/06 ,  C07H11/04 ,  C07H15/203 ,  C08B37/00

    Abstract: PROBLEM TO BE SOLVED: To obtain the new subject compound comprising a specific inositol glucan, having good serum stability and insulin-like activities against insulin resistant tissue, and useful for treatment, etc., of diabetes mellitus or noninsulin dependent diabetes mellitus. SOLUTION: The subject compound is a new inositol glucan of the formula A-Z-R [A is H-P(O) (OH), H-P(S) (OH), HO-P(S) (OH), (a 1-4C alkyl)-P(O) (OH), S(O)2 (OR ) (R is H or a 1-4C alkyl), R R N (R is same as R ), etc.; Z is 2-6 (substituted) saccharide groups; R is inositol, inositol phosphate, inositol thiophosphate, inositol cyclophosphate, inositol cyclothiophosphate, etc.]. The compound has in-vitro insulin-like activities, good serum stability and insulin-like activities against insulin resistant tissue and is useful for treatment, etc., of diabetes mellitus or noninsulin dependent diabetes mellitus.

    3.
    发明专利
    未知

    公开(公告)号：AT184611T

    公开(公告)日：1999-10-15

    申请号：AT92119913

    申请日：1992-11-23

    Applicant: HOECHST AG

    Inventor： FRICK WENDELIN DR ,  MUELLER GUENTER DR ,  MUELLNER STEFAN DR ,  BREIPOHL GERHARD DR

    IPC: A61K38/28 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  C07K5/087 ,  C07K5/093 ,  C07K5/097 ,  C07K7/06 ,  C07K7/08 ,  C07K9/00

    Abstract: Peptides with insulin-like activity and the formula I where C is a hydrogen atom, amino-acid residue, substituted amino-acid residue or sugar residue, D is an amino-acid residue, phosphoamino-acid residue, sugar residue, covalent bond or hydroxyl radical, E is a hydrogen atom, hydroxyl radical, substituted sugar residues, substituted alkyldiamine or glycerol residue, R is (C1-C4)-alkyl, =O or -O-(C1-C4)-alkyl, R is a sulphur protective group, SO2, SO3, (C1-C3)-alkyl, O2 radical, O3 radical, or hydrogen atom, R or R is, independently of one another, hydrogen or methyl, and W is an integer 1 or 2, the preparation and use thereof for the treatment of diabetes mellitus or non-insulin-dependent diabetes are described.

    7.
    发明专利
    未知

    公开(公告)号：DE59202472D1

    公开(公告)日：1995-07-20

    申请号：DE59202472

    申请日：1992-01-23

    Applicant: HOECHST AG

    Inventor： AIGNER RUDOLF ,  MUELLER GUENTER DR ,  SCHOLZ HANS JUERGEN DR ,  WEHLE DETLEF DR

    IPC: C07C213/02 ,  C07C213/04 ,  C07C215/10

    Abstract: The novel process is based on the reaction of a dialkylamine, preferably dimethylamine or diethylamine, with a monohalopropanediol, preferably monochloropropanediol, in the presence of water. The reaction is carried out in the presence of 25 to 70% by weight of water and at a temperature of from 20 to 80 DEG C, the dialkylamine being employed in an amount of at least 2.5 mol per mol of monohalopropanediol. The novel process allows a high space-time-yield and also a high chemical yield of virtually pure dialkylaminopropanediol to be obtained.

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