公开(公告)号：DE58902217D1

公开(公告)日：1992-10-15

申请号：DE58902217

申请日：1989-01-31

Applicant: HOECHST AG

Inventor： AIGNER RUDOLF ,  MUELLER GUENTHER DR ,  MUELLER RAINER ,  REUNER HORST

IPC: C07C303/24 ,  C07C303/44 ,  C07C305/04 ,  C07C305/06 ,  C07C305/00 ,  C07C305/10 ,  C07C305/18 ,  C09K23/02 ,  C11D3/34

Abstract: A process for the preparation of sulfated alkanol oxethylates or alkylphenol oxethylates is described. After completion of the reaction with SO3, 0.1 to 0.5% by weight, relative to the alkanol oxethylates or alkylphenol oxethylates employed, of at least one of the following compounds: water, ethanol, 1-propanol, 2-propanol or n-heptane are admixed to the reaction mixture and liquid and gas are subsequently separated at a temperature of 20 DEG to 60 DEG C. The liquid is then neutralized with aqueous alkali as customary and leads to ether sulfate/water mixtures with considerably reduced contents of 1,4-dioxane which can either be used without further aftertreatment or with a considerably reduced outlay in terms of aftertreatment as personal hygiene agents and for various other purposes.

公开(公告)号：DE4314260A1

公开(公告)日：1994-11-03

申请号：DE4314260

申请日：1993-04-30

Applicant: HOECHST AG

Inventor： MUELLNER STEFAN DR ,  MUELLER GUENTHER DR ,  KOENIG WOLFGANG DR

IPC: A61K38/00 ,  C07K5/103 ,  C07K14/62 ,  C07K5/10 ,  A61K37/02 ,  C07K7/06

Abstract: Peptides of the formula I, H2N-A-B-C-D-Leu-E-F-Tyr, containing 2 to 8 amino acid residues, are suitable for the treatment of hypoglycaemia. These peptides are used in particular for the treatment of physiological states characterized by a blood glucose content which is too low.

公开(公告)号：AT80383T

公开(公告)日：1992-09-15

申请号：AT89101596

申请日：1989-01-31

Applicant: HOECHST AG

Inventor： AIGNER RUDOLF ,  MUELLER GUENTHER DR ,  MUELLER RAINER ,  REUNER HORST

IPC: C07C305/00 ,  C07C303/24 ,  C07C303/44 ,  C07C305/04 ,  C07C305/06 ,  C07C305/10 ,  C07C305/18 ,  C09K23/02 ,  C11D3/34

公开(公告)号：DE3907578A1

公开(公告)日：1990-10-11

申请号：DE3907578

申请日：1989-03-09

Applicant: HOECHST AG

Inventor： AIGNER RUDOLF DIPL ING ,  MUELLER GUENTHER DR

IPC: C07C209/12 ,  C07C209/84

Abstract: In the novel process, the quaternisation mixture obtained by customary quaternisation of primary or secondary amines with an alkyl halide in a lower alkanol as a solvent and in the presence of aqueous alkali metal hydroxide is treated in such a manner that the amount of water in the quaternisation mixture is first distillatively reduced to at least 6% by weight and only after this reduction of water is the alkali metal halide separated off.

公开(公告)号：DE3803110A1

公开(公告)日：1989-08-17

申请号：DE3803110

申请日：1988-02-03

Applicant: HOECHST AG

Inventor： AIGNER RUDOLF DIPL ING ,  MUELLER GUENTHER DR ,  MUELLER RAINER ,  REUNER HORST DIPL ING

IPC: C07C305/00 ,  C07C303/24 ,  C07C303/44 ,  C07C305/04 ,  C07C305/06 ,  C07C305/10 ,  C07C305/18 ,  C09K23/02 ,  C11D3/34

Abstract: A process for the preparation of sulfated alkanol oxethylates or alkylphenol oxethylates is described. After completion of the reaction with SO3, 0.1 to 0.5% by weight, relative to the alkanol oxethylates or alkylphenol oxethylates employed, of at least one of the following compounds: water, ethanol, 1-propanol, 2-propanol or n-heptane are admixed to the reaction mixture and liquid and gas are subsequently separated at a temperature of 20 DEG to 60 DEG C. The liquid is then neutralized with aqueous alkali as customary and leads to ether sulfate/water mixtures with considerably reduced contents of 1,4-dioxane which can either be used without further aftertreatment or with a considerably reduced outlay in terms of aftertreatment as personal hygiene agents and for various other purposes.

公开(公告)号：DE3528985A1

公开(公告)日：1987-02-19

申请号：DE3528985

申请日：1985-08-13

Applicant: HOECHST AG

Inventor： AIGNER RUDOLF ,  BLASCHKE GUENTER DR ,  MUELLER GUENTHER DR

IPC: C07C209/00 ,  C07C67/00 ,  C07C209/12 ,  C07C211/21 ,  C07C211/63 ,  C07C239/12 ,  C07C87/30

公开(公告)号：DE3672539D1

公开(公告)日：1990-08-16

申请号：DE3672539

申请日：1986-07-30

Applicant: HOECHST AG

Inventor： AIGNER RUDOLF ,  BLASCHKE GUENTER DR ,  MUELLER GUENTHER DR

IPC: C07C209/00 ,  C07C67/00 ,  C07C209/12 ,  C07C211/21 ,  C07C211/63 ,  C07C239/12

公开(公告)号：DE4102394A1

公开(公告)日：1992-07-30

申请号：DE4102394

申请日：1991-01-28

Applicant: HOECHST AG

Inventor： AIGNER RUDOLF DIPL ING ,  MUELLER GUENTHER DR ,  SCHOLZ HANS JUERGEN DR ,  WEHLE DETLEF DR

IPC: C07C213/02 ,  C07C213/04 ,  C07C215/10

Abstract: The novel process is based on the reaction of a dialkylamine, preferably dimethylamine or diethylamine, with a monohalopropanediol, preferably monochloropropanediol, in the presence of water. The reaction is carried out in the presence of 25 to 70% by weight of water and at a temperature of from 20 to 80 DEG C, the dialkylamine being employed in an amount of at least 2.5 mol per mol of monohalopropanediol. The novel process allows a high space-time-yield and also a high chemical yield of virtually pure dialkylaminopropanediol to be obtained.

公开(公告)号：DE3530101A1

公开(公告)日：1987-02-26

申请号：DE3530101

申请日：1985-08-23

Applicant: HOECHST AG

Inventor： AIGNER RUDOLF ,  BILLENSTEIN SIEGFRIED DR ,  EHRL WINFRIED DR ,  GRABLEY FRITZ-FEO DR ,  MUELLER GUENTHER DR

IPC: C07C309/42 ,  C07C143/38

Abstract: A process is described for the preparation of acyloxybenzenesulphonates which are optionally substituted on the benzene ring. Liquid acyloxybenzene which is optionally substituted on the benzene ring is brought into contact with a gas mixture containing 1 to 7% by volume of SO3 at 20 to 200 DEG C. When 1 mol of the acyloxybenzene which is optionally substituted on the benzene ring has taken up 0.9 to 1.3 mol of SO3, SO3-feeding is stopped, the liquid is held at a temperature of 20 to 70 DEG C for 5 to 180 minutes and then neutralised. In this manner, acyloxybenzenesulphonates which is optionally substituted on the benzene ring can be prepared in good quality and good yield without solvents and without it being necessary to remove troublesome reaction products.