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    PROCESS FOR PREPARING HEXAHYDRO-PYRIMIDINE COMPOUNDS
    2.
    发明授权
    PROCESS FOR PREPARING HEXAHYDRO-PYRIMIDINE COMPOUNDS 失效

    公开(公告)号：KR810000804B1

    公开(公告)日：1981-07-08

    申请号：KR780001786

    申请日：1978-06-12

    Applicant: HOECHST AG

    Inventor： ANAGNOSTOPULOS H ,  WEBER R ,  GEBERT U

    IPC: A61K31/505 ,  C07D401/06

    Abstract: Title compds. [I; R1 = H, C1-2 alkyl, Ph, tolly1; R2-R5 = H, C1-2 alkyl; R6 = H, C1-3 substituent with O-position-condensed benzene or C1-3 alkoxy or halo-substituted alkyl having halo, NO2 or OH; A = single bond or C6H5-CH; Q = single bond or alkylene group of formula -CnH2n-(n = 2-6); X = O, S; Z = N or -CH having anti-coagulation or anti-serotonin activity were prepd. by eliminating R7(that is OH) in compds. II or by reacting compds. III with halogen compds. IV(3-isocyanato- or 3-isocyanato-alkano carboxylic acid; Hal = halo) or dihalogen compds. (IVa).

    CYCLIC DIAMINE N,N'-DISUBSTITUTED AND PROCESS FOR PREPARING THE SAME
    3.
    发明申请
    CYCLIC DIAMINE N,N'-DISUBSTITUTED AND PROCESS FOR PREPARING THE SAME 审中-公开
    循环二胺N，非取代和其制备方法

    公开(公告)号：WO1979000426A1

    公开(公告)日：1979-07-12

    申请号：PCT/DE1978000040

    申请日：1978-12-16

    Applicant: HOECHST AG

    Inventor： HOECHST AG ,  PERREY K ,  WEBER R ,  RECHENBERG W

    IPC: C07D405/06

    CPC classification number: C07D307/85

    Abstract: Compound having the formula (FORMULA) or its salts of addition of acids physiologically acceptable and process for its preparation, wherein is reacted: a) N-benzylpiperazine and 5-methoxy-benzofurane-2-carboxylic acid, a1) at a higher temperature and without using a condensing agent or a2) at a temperature of at least 15` C in presence of appropriate condensing agents, b) N-benzylpiperazine with an activated sub-product of 5-methoxybenzofurane-2-carboxylic acid or c) N-(5-methoxy-2-benzofuroyl)-piperazine with a benzyl halide, an alkyl-sulfonate of benzyl or an aryl-sulfonate of benzyl. Medicine, containing the above compound.

    Abstract translation: 具有式（式）的化合物或其生理上可接受的酸加成盐及其制备方法，其中反应：a）N-苄基哌嗪和5-甲氧基 - 苯并呋喃-2-羧酸，a1）在较高温度和 不使用缩合剂或a2）在适当的缩合剂存在下在至少15℃的温度下进行，b）N-苄基哌嗪与5-甲氧基苯并呋喃-2-羧酸的活化副产物或c）N-（ 5-苄氧基-2-甲氧基-2-苯并呋喃基） - 哌嗪与苄基卤，苄基的烷基磺酸盐或苄基的芳基磺酸盐。 含有上述化合物的药物。

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